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Pediatric Neurology

Vikram Jakkamsetti, Ph.D.

My primary work explores mechanistic links between energy metabolism and neuronal electrophysiology in the context of seizures and intellectual disability in related pediatric encephalopathies. I also collaborate to find the molecular, synaptic and neurophysiological underpinnings of rodent behavior impacted by mutations.

Juan Pascual, M.D., Ph.D.

Our laboratory includes a diverse group of bench and data scientists and clinical scientists interested in the interplay of metabolism and neural activity [hyperlink to Publications]. This implies the use (and sometimes the development) of quantitative approaches such as single-cell and circuit electrophysiology, NMR spectroscopy, genetic manipulation and animal model behavioral analysis which, when feasible, has led to clinical trials that inform medical practice. Thus, problems are approached from beginning to end by the group: from scientific conceptualization to clinic implementation. The collaborative environment is unmatched. The lab has established robust collaborations at the institution and elsewhere, and is funded in part by private donations from patients and NIH Grants.

Peter Tsai, M.D., Ph.D.
Assistant Professor

The Tsai laboratory studies the molecular and circuit mechanisms underlying cognitive and behavioral disability in neurodevelopmental and neuropsychiatric disorders, with a primary interest in the contribution of cerebellar dysfunction to cognitive and neurobehavioral impairment in these disorders.