Research Studies

The Alzheimer's Disease Center (ADC) is looking for volunteers to help us learn more about memory loss. To volunteer, fill out our Join a Study form or contact the research coordinators listed with each study.

LOAD (Late-Onset Alzheimer’s Disease) Study

This study is being done to help researchers learn more about risk factors which might be associated with the development of diseases of the nervous system associated with late-onset Alzheimer’s disease (late onset is defined as symptoms of AD beginning at age 60 or older), aging, and other related disorders. Other related disorders may include early-onset Alzheimer’s disease, frontotemporal degeneration, Lewy body dementia, corticobasal degeneration, and progressive supranuclear palsy.

Study procedures: Participation will involve an annual visit, either in person or by phone, which could take approximately 2 hours.

Medical and Family History Interview Neurological Exam Memory and Blood Tests

Basic qualifications of this research study:

  • Ages of 50 and older, fluent in English
  • Have a close family member or friend who can serve as a study partner and answer questions about your memory and your problem-solving ability
  • Have at least 2 living family members with dementia and at least one family member who does not have dementia

For more information on this study, contact Amy Browning: 214-645-1972, or amy.browning@utsouthwestern.edu.

CORE Study (Neurobiology of Alzheimer's Disease and Aging)

This study is being done to follow the effects of aging over time by collecting data about participants through cognitive testing and detailed questionnaires. Data from this study will help researchers better characterize participants who have no cognitive problems or dementia, to those who have some cognitive problems, and those who have dementia.

Study procedures: Participation will involve an annual visit which could take approximately 4 hours.

  • Medical and Family History Interview
  • Neurological Exam
  • Memory and Blood Tests

Basic qualifications of this research study:

  • Ages of 18 and older, fluent in English
  • Have a close family member who can serve as a study partner and answer questions about your memory and your problem-solving ability

For more information on this study, contact Lindsey Gonzalez: 214-648-9331 or lindsey.gonzalez@utsouthwestern.edu.

DVR Study (Dynamic Vasomotor Reactivity in Alzheimer Disease)

The Dynamic Vasomotor Reactivity (DVR) in Alzheimer Disease study is collecting blood flow information of older adults who are either cognitively normal, or with mild cognitive impairment, or with mild Alzheimer's disease. Researchers would like to know if the change in participants’ blood flow correlates with the change shown on study tests and brain imaging over the course of 3 years.

Study procedures: The following procedures will be done annually, which could take approximately 4 visits to UTSW each year. Participants will be compensated for their time.

  • Medical and Family History Interview
  • Neurological Exam
  • Memory and Blood Tests
  • MRI and PET-Scan
  • Dynamic Vasomotor Reactivity: Non-invasive exams of your blood flow
  • Optical coherence tomography (OCT) and Pupillometry: Non-invasive techniques to scan your pupil and retina

Basic qualifications of this research study:

  • Ages of 55-85, fluent in English
  • Have a close family member who can serve as a study partner and answer questions about your memory and your problem solving ability
  • Women must be at least two years postmenopausal or surgically sterile
  • No pacemaker or metal fragments in your body, or claustrophobic for an MRI
  • No history or ongoing major depression, bipolar disorder, stroke, or transient ischemic attack (TIA)
  • No alcohol or substance abuse/dependence within the past 2 years

For more information on this study, contact Hsin-Fen Yang: 214-645-0375 or hsin-fen.yang@utsouthwestern.edu.