Dr. Roger Rosenberg drives research of Alzheimer’s DNA vaccine
Research led by Dr. Roger Rosenberg shows the potential of a new DNA vaccine in the fight against Alzheimer's Disease. The vaccine prompts an immune response that produces antibodies to protect against toxic proteins
associated with Alzheimer’s disease, without causing the severe brain swelling seen in some patients of earlier antibody treatments.
Two studies from the Peter O’Donnell Jr. Brain Institute demonstrate in animals how a vaccine containing DNA of the toxic beta-amyloid protein elicits a different immune response that may be safe for humans.
“We believe this kind of immune response has a high probability of being safe in humans and also being effective to make high levels of antibody,” said Dr. Rosenberg, co-author of the studies and Director of the Alzheimer’s Disease Center at UT Southwestern Medical Center.