Grants and Research

Studying how tuberculosis spreads and why patients cough

 

Dr. Michael Shiloh, Associate Professor of Internal Medicine and Microbiology in the Division of Infectious Diseases and Geographic Medicine, has spent nearly two decades studying tuberculosis, which kills about 1.5 million people a year, mostly in developing countries. Despite heightened focus on the current COVID-19 global pandemic, TB remains the No. 1 cause of death from an infectious disease.

“When I started out in science, it seemed like everyone was striving to make a big contribution to their fields, but most individual discoveries are small,” Dr. Shiloh says. “Tuberculosis is a serious global health issue, so I felt that even a small contribution to a massive problem would be meaningful.“

Dr. Shiloh awarded grant to develop new therapeutic approaches to infections.

 

Amid growing concern about pathogens becoming more drug-resistant worldwide – and emerging new pathogens that have no current treatment – UT Southwestern has been selected to lead a five-year investigation into a promising new approach for controlling infections funded by a grant of up to $37 million.

The National Institutes of Health (NIH)-funded program will be headed by Dr. Beth Levine, Director of UT Southwestern’s Center for Autophagy Research and a Professor of Internal Medicine and Microbiology. She will serve as Program Director over five separate research projects at UT Southwestern and across the country – all focused on the potential to exploit a cellular process known as autophagy to destroy invading bacteria and viruses.

“During autophagy, the target to be destroyed is encased in a double-membrane compartment inside the cell called an autophagosome, which then merges with other compartments containing enzymes and acids to degrade the target,” said Dr. Michael Shiloh, Associate Professor of Internal Medicine and Microbiology, who will assist Dr. Levine as the program’s Associate Director.

Dr. Cutrell awarded SWAT education grant

 

Dr. James Cutrell was awarded the one year educational grant through Southwestern Academy of Teachers (SWAT) to pilot an innovative mobile app for Internal Medicine residents and Infectious Diseases fellows to review for board exams. The app uses spaced interval learning philosophy to deliver board review questions to the trainees for review with feedback.

Dr. Shiloh receives support from Welch Foundation

 

The Welch Foundation grants Dr. Michal Shiloh and award for his studies on "Activation of nociceptive neurons by mycobacterial bioactive lipids."

Dr. Shiloh awarded Burroughs Wellcome Fund

 

Dr. Michael Shiloh awarded grant from Burroughs Wellcome Fund. The award is given to test the hypothesis that Mycobacterium tuberculosis releases bioactive lipids to target cough-inducing nociceptive neurons as a mechanism of bacterial transmission.

NIH-NIAID gives support to study TB transmission

 

The NIH: National Institute of Allergy and Infectious Diseases has awarded Dr. Michal Shiloh a grant for studies on "Transmission dynamics of Mycobacterium tuberculosis."

Dr. Bedimo awarded by NIH-NHLBI

 

Dr. Roger Bedimo is award an NIH-National Heart, Lung and Blood Institute grant for study of "HDL Cholesterol Efflux Capacity and Cardiovascular Disease in HIV; Impact of HAART"

Dr. Jain awarded CPRIT funding for Hep C Screening

 

The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded UT Southwestern researchers more than $27 million, including nearly $3 million for two key cancer screening programs in underserved areas, lung cancer screenings and Liver Cancer/Hepatitis C screening. Dr. Mamta Jain, Director of the HIV Research Unit at UT Southwestern, will conduct hepatitis C screening among baby boomers, with the goal of reducing the incidence of liver cancer.

The two-part program involves developing a population-based electronic alert at John Peter Smith Hospital and using a mobile van to screen residents in eight North Texas counties. The program aims to screen more than 20,000 patients through combined efforts at JPS and community outreach programming.

Dr. Ank Nijhawan is awarded an R34 grant from the NIH

 

Dr. Ank Nijhawan is awarded an R34 grant from the NIH to improve re-engagement in HIV care after release from jail through a community-clinic collaboration. HIV health disparities are overrepresented in the criminal justice system. Dr. Nijhawan’s work is aimed to reduce these health disparities and improve HIV outcomes.

Dr. Jain receives CPRIT grant for STOP HCC

 

Cancer Prevention Research Institute of Texas awarded Mamta Jain, M.D., a grant for STOP HCC: Evidence-Based Hepatocellular Cancer Prevention targeting Hepatitis C Virus Infection.