Phase VIII – Pre-clinical Studies

Researchers studied the effects of cholinesterase-inhibiting chemicals on the brain in a laboratory rodent model of Gulf War illness (2009-2010).

A. Studies in a rodent model of Gulf War illness

1. Development of the rodent model of Gulf War illness [References]
2. Neuronal signal transduction (Bibb) [References]
3. Cholinergic signaling (Cooper)  [References]
4. Mitochondrial calcium metabolism (Bezprozvanny)
5. Hippocampal synaptic transmission [References]

B. Disease-specific models

1. ALS mouse model (Elliott) [References]
2. Glioblastoma model (Bachoo)
3. Autonomic nervous system model (Vernino)  [References]

C. Demonstrated that gene therapy to boost serum PON1 isoenzymes protects rats from organophosphate toxicity. [References]