Green Center Faculty

The Green Center consists of seven faculty members from the Department of Obstetrics and Gynecology, as well as more than 20 additional members from a variety of other departments across campus.

Our faculty work in wide areas related to reproductive biology, gene regulation, genomics, stem cells, RNA biology, structural biology, and biochemistry.

Core Green Center Faculty

Affiliated Members

Research Focus Areas and Other UTSW Faculty 


Core Green Center Faculty

The core Green Center faculty work in the areas of signaling, gene regulation, and nuclear function in reproduction, development, metabolism, cancer, inflammation, and stem cells.

 

Laura Banaszynski, Ph.D.

Photograph of Laura Banaszynski

Obstetrics and Gynecology
Laboratory: Banaszynski Lab
laura.banaszynski@utsouthwestern.edu

Research: Dr. Banaszynski studies epigenetic contributions to gene expression and genome stability in mammalian systems. Her research focuses on the dynamic regulation of chromatin states at both coding and non-coding regions including the influence of histone variant incorporation on histone post-translational modification states. Her long-term goal is to improve our understanding of the chromatin-based mechanisms regulating fundamental cell-fate decisions in pluripotency and differentiation that are essential to our understanding of developmental processes.

 

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Gary Hon, Ph.D.

Photograph of Gary Hon

Obstetrics and Gynecology
Laboratory: Hon Lab
gary.hon@utsouthwestern.edu

Research: Our primary research interest is to develop a comprehensive understanding of how the millions of non-coding regulatory elements encoded in our genomes precisely coordinate gene expression in developmental and disease contexts. A major focus is elucidating how genetic and epigenetic dysregulation of transcriptional enhancers supports a cancer cell’s altered transcriptional program. To accomplish this, we take a systems biology approach: developing and employing integrative techniques at the interface of gene regulation, epigenetics, functional genomics, and bioinformatics. 

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W. Lee Kraus, Ph.D. 

Photograph of Lee Kraus

Obstetrics and Gynecology
Laboratory: Kraus Research Laboratory
lee.kraus@utsouthwestern.edu

Research: Mechanisms of nuclear signaling and gene regulation by small molecules and the relationship of these signaling pathways to human diseases. Our focus is on two distinct, but probably related, nuclear signaling pathways controlled by estrogens and NAD.

 

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Xin Liu, Ph.D.

Photograph of Xin Liu

Obstetrics and Gynecology, Biophysics
Laboratory: Liu Lab
xin.liu@utsouthwestern.edu

Research: Using structural biology to study the molecular mechanisms of pRb inactivation by a viral oncoprotein, the structural basis of protein acetylation by p300/CBP, and the mechanisms of transcriptional initiation by RNA polymerase II and associated factors. He will address the molecular mechanisms of start site selection for RNA polymerase II. In parallel, he will explore the RNA polymerase II transcription in the context of the three-dimensional structure of the genome, focusing on transcription-dependent gene looping.

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Mala Mahendroo, Ph.D.

Photograph of Mala Mahendroo

Obstetrics and Gynecology
Laboratory: Mahendroo Laboratory
mala.mahendroo@utsouthwestern.edu

Research: My research interests include an understanding of the molecular mechanisms by which the cervix remodels during pregnancy, parturition and postpartum to allow birth and subsequent recovery of the cervix to the nonpregnant state. Our focus is on understanding the contribution of the extracellular matrix, immune cells, and cervical cells to this process and their regulation during all phases of cervical remodeling.

 

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Yunsun Nam, Ph.D.

Photograph of Yunsun Nam

Obstetrics and Gynecology
Laboratory: Nam Lab
yunsun.nam@utsouthwestern.edu

Research: Mechanisms of non-coding RNAs and their role in gene regulation important for development and cancer. A major focus is the molecular mechanism and regulation of microRNA processing. The long-term goal is not only to elucidate how ncRNAs work but also to identify new avenues for developing therapeutics.

Ann Word, M.D.

Photograph of Ann Word

Obstetrics and Gynecology
Laboratory: Word Laboratory
ann.word@utsouthwestern.edu

Research: Mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter).

 

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Affiliated Members

 

Michael Buszczak, Ph.D.
Molecular Biology
Laboratory: Buszczak Lab
Michael.Buszczak@UTSouthwestern.edu
Research:The Buszczak lab studies several Drosophila stem cells lineages as a model for understanding how cells adopt different fates. The long-term goal is to determine the complete regulatory network that controls both the maintenance of Drosophila stem cells and the differentiation of their daughters. We hope to use this information as a foundation for understanding how perturbations in normal gene expression programs cause disease.

Bruce Carr, M.D.
Division of REI/Department of Obstetrics and Gynecology
bruce.carr@utsouthwestern.edu
Research: Regulation of Steroidogensis in the ovary, adrenal, and placenta. Specifically, the regulation of CYP 17 expression. In addition, conducting clinical trials of women with endometriosis, uterine leiomyoma, infertility, and fertility control.

Diego Castrillon, M.D., Ph.D.
Pathology
Laboratory: Castrillon Lab
diego.castrillon@utsouthwestern.edu
Research: The Castrillon laboratory has broad interests in the intersection of reproduction, infertility, and cancer. Areas of special interest include P13K/Foxo signaling in the control and preservation of the gemline and the role of the LKB1/MTOR pathway in diverse cancers of the reproductive tract.

Cheng-Ming Chiang, Ph.D.
Cancer Center/Pathology
Laboratory: Chiang Lab
cheng-ming.chiang@utsouthwestern.edu
Research: Epigenetic control of gene regulation, mechanisms of transcriptional regulation in mammalian cells and in human papillomaviruses, and posttranslational modification of protein function.

Joel Elmquist, D.V.M., Ph.D.
Internal Medicine/Hypothalamic Research
Laboratory: Elmquist Lab
joel.elmquist@utsouthwestern.edu
Research: Dr. Elmquist's research focuses on identifying the pathways in the brain regulating body weight and glucose homeostasis. Toward these goals, Dr. Elmquist and colleagues have developed several mouse models that allow specific manipulation of key genes regulating energy balance and glucose homeostasis.

F. Kent Hamra, Ph.D.
Obstetrics and Gynecology
kent.hamra@utsouthwestern.edu
Research: Research in Dr. Hamra’s laboratory is based on the Biology and Applications of Sperm Stem Cells. Understanding the genetic basis of spermatogenesis could lead to strategies to correct male infertility, the discovery of specific gene targets for new male contraceptives, the invention of new technologies to advance animal genetics, novel cancer therapies and even an ability to select against detrimental genetic defects directly in the germline.

Taekyung Kim, Ph.D.
Neuroscience
Laboratory: Kim Lab
taekyung.kim@utsouthwestern.edu
Research: Dr. Kim's research focuses studying how neuronal activity controls gene expression in neurons to mediate synapse remodeling and plasticity.

Ralf Kittler, Ph.D.
Eugene McDermott Center for Growth and Development
Laboratory: Kittler Lab
ralf.kittler@utsouthwestern.edu
Research: Cancer genomics. The Kittler lab is studying cancer-specific genetic programs, which are key for the development of new diagnostic, prognostic, and therapeutic strategies. We combine analyses of the genomic binding sites (ChIP-Seq) of cancer-relevant transcription factors, epigenetic, gene expression, and clinical outcome data to make specific predictions about the role of transcription factors and functional interaction of multiple transcription factors in the regulation of cancer-relevant gene networks. 

David Mangelsdorf, Ph.D.
Pharmacology
Laboratory: Mangelsdorf-Kliewer Lab
davo.mango@utsouthwestern.edu
Research: The Mangelsdorf/Kliewer lab studies nuclear receptor regulation of metabolism and cancer. Recent studies have elucidated two endocrine signaling pathways mediated by fibroblast growth factors that govern fasting and feeding.

Carole Mendelson, Ph.D.
Biochemistry, Obstetrics and Gynecology
Laboratory: Mendelson Laboratory
carole.mendelson@utsouthwestern.edu
Research: Genetic and epigenetic mechanisms that mediate expression of specific genes in a tissue- and cell-specific manner, that activate gene expression at distinct phases of embryonic development, and modulate their expression by hormones and second messengers.

Chieko Mineo, Ph.D.
Pediatrics
Laboratory: Mineo Lab
Chieko.Mineo@UTSouthwestern.edu
Research: The Mineo lab is working to identify the molecular components, the protein-protein interactions, and the regulatory events occurring within signaling modules on the plasma membrane which dictate endothelial cell phenotype and the propensity for vascular disease.

Eric Olson, Ph.D.
Molecular Biology
Laboratory: Olson Lab
eric.olson@utsouthwestern.edu
Research: Our lab studies muscle cells as a model for understanding how embryonic cells adopt specific fates, and how programs of cell differentiation and morphogenesis are controlled during development. We have focused on discovering novel transcription factors and extracellular signals, as well as novel transcription factors that control development of these muscle cell types and remodeling in response to cardiovascular and neuromuscular diseases.

Ganesh Raj, M.D., Ph.D.
Urology/Pharmacology
Laboratory: Raj Lab
ganesh.raj@utsouthwestern.edu
Research: The Raj laboratory focuses on deciphering the mechanisms of resistance to hormonal therapies in prostate and breast cancers, the development and validation of drugs targeting the nuclear receptors in prostate and breast cancer, molecular characterization of hormone dependent signaling pathways in prostate and breast cancers, as well as the understanding mechanisms of radiation resistance in prostate cancers, and ex vivo development of primary cancer models that maintain the critical signaling pathways to dissect the biology of individual cancers and predict responsiveness to therapeutics.

Charles Rosenfeld, M.D.
Pediatrics, Obstetrics and Gynecology, Anesthesiology
charles.rosenfeld@utsouthwestern.edu
Research: My lab is interested in establishing the mechanisms that contribute to the regulation of uteroplacental and fetal umbilical blood flows during pregnancy, in particular estrogens, K channels, and angiotensin II, and how they are modified in disease states such as maternal hypertension and diabetes. We are also interested in understanding vascular smooth muscle development, how that contributes to prenatal and postnatal blood pressure regulation, and how alterations in fetal growth and development alter subsequent blood pressure regulation in infancy, childhood, and the adult.

Philip Shaul, M.D.
Pediatrics
Laboratory: Shaul-Mineo-Umetani Lab
philip.shaul@utsouthwestern.edu
Research: Our lab is primarily engaged in endothelial cell biology. Our overall goal is to identify the molecular components, the protein-protein interactions, the regulatory events occurring within signaling modules on the plasma membrane which dictate endothelial cell phenotype, and the propensity for vascular disease. Investigations are performed in cell culture models and in both in vitro and in vivo reconstitution systems in genetically modified mice.

Clifford Wai, M.D.
Division of Urogynecology, Department of Obstetrics and Gynecology
Laboratory: Wai Lab
clifford.wai@utsouthwestern.edu
Research: Animal models for lower urinary tract dysfunction and anal incontinence. More recently, interests have included exploring the role of mechanical trauma, denervation, pregnancy, and the effects of growth factors and myogenic stem cells on wound healing of the external anal sphincter. Other research interests include urogynecology education, functional anatomy and biomechanics of gynecologic surgical procedures, patient outcomes in incontinence, and pelvic organ prolapse.

Yihong Wan, Ph.D.
Pharmacology
Laboratory: Yihong Wan Lab
yihong.wan@utsouthwestern.edu
Research: Our long-term goal is to understand how the nuclear receptor family of transcription factors and associated pathways regulate development, metabolism, and cancer, using the skeleton and the mammary gland as model systems. 

Jiang Wu, Ph.D.
Physiology
Laboratory: Jiang Wu Lab
jiang9.wu@utsouthwestern.edu
Research: We are interested in chromatin regulation of signaling pathways that are important for stem cell self-renewal and differentiation. The current focus is the function of ATP-dependent chromatin remodeling complexes in embryonic and neural development.

Jian Xu, Ph.D.
Children's Medical Center Research Institute at UTSW
Laboratory: Jian Xu Lab
jiang9.wu@utsouthwestern.edu
Research: We are interested in chromatin regulation of signaling pathways that are important for stem cell self-renewal and differentiation. The current focus is the function of ATP-dependent chromatin remodeling complexes in embryonic and neural development.

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