Publications
2022
RNA induces unique tau strains and stabilizes Alzheimer's disease seeds
Zwierzchowski-Zarate AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, White CL 3rd, Diamond MI.
J Biol Chem. 2022 Jun 11:102132. doi: 10.1016/j.jbc.2022.102132. Online ahead of print.
The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification
Kolay S, Vega AR, Dodd DA, Perez VA, Kashmer OM, White CL 3rd, Diamond MI.
J Biol Chem. 2022 May 5;298(6):102014. doi: 10.1016/j.jbc.2022.102014. Online ahead of print.
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics
Wickramaratne AC, Li L, Hopkins JB, Joachimiak ŁA, Green CB.
Biochemistry. 2022 May 10. doi: 10.1021/acs.biochem.2c00072. Online ahead of print.
Modifying Amyloid Motif Aggregation Through Local Structure
Bali S, Joachimiak ŁA.
Methods Mol Biol. 2022 ;2340:343-356. doi: 10.1007/978-1-0716-1546-1_15.
Chaperoning shape-shifting tau in disease
Ryder BD, Wydorski PM, Hou Z, Joachimiak ŁA.
Trends Biochem Sci. 2022 Apr;47(4):301-313. doi: 10.1016/j.tibs.2021.12.009.
2021
Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
Ryder, BD, Matlahov, I, Bali, S, Vaquer-Alicea, J, van der Wel, PCA, Joachimiak, Ł.
Nat Commun 2021 12, 946. doi:10.1038/s41467-021-21147-x
Tau strains shape disease
Vaquer-Alicea, J, Diamond, MI, Joachimiak, Ł.
Acta Neuropathol 2021. doi: 10.1007/s00401-021-02301-7.
AAV9-mediated FIG4 delivery prolongs life span in Charcot-Marie-Tooth disease type 4J mouse model
Presa M, Bailey RM, Davis C, Murphy T, Cook J, Walls R, Wilpan H, Bogdanik L, Lenk GM, Burgess RW, Gray SJ, Lutz C.
J Clin Invest. 2021 Jun 1;131(11):e137159. doi: 10.1172/JCI137159.
Gene Transfer Therapy for Neurodevelopmental Disorders
Ozlu C, Bailey RM, Sinnett S, Goodspeed KD.
Dev Neurosci. 2021 ;43(3-4):230-240. doi: 10.1159/000515434.
Extensive rod and cone photoreceptor-cell degeneration in rat models of giant axonal neuropathy: implications for gene therapy of human disease
Armao D, Bouldin TW, Bailey RM, Gray SJ.
Ophthalmic Genet vol. 42,5 (2021): 600-603. doi:10.1080/13816810.2021.1923036
Biophysical properties of a tau seed
Hou, Z, Chen, D, Ryder, BD, Joachimiak, Ł.
Sci Rep 11, 13602 (2021). doi: 10.1038/s41598-021-93093-z
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation
Hou Z, Wydorski PM, Perez VA, Mendoza-Oliva A, Ryder BD, Mirbaha H, Kashmer O, Joachimiak LA.
Nat Commun. 2021 Sep 9;12(1):5338. doi: 10.1038/s41467-021-25635-y.
Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns
Stopschinski BE, Del Tredici K, Estill-Terpack SJ, Ghebremdehin E, Yu FF, Braak H, Diamond MI.
Acta Neuropathol Commun. 2021 Oct 11;9(1):164. doi: 10.1186/s40478-021-01255-x.
Tau seeding in chronic traumatic encephalopathy parallels disease severity
Kaufman SK, Svirsky S, Cherry JD, McKee AC, Diamond MI.
Acta Neuropathol. 2021 Dec;142(6):951-960. doi: 10.1007/s00401-021-02373-5.
Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF
Hitt BD, Vaquer-Alicea J, Manon VA, Beaver JD, Kashmer OM, Garcia JN, Diamond MI.
Acta Neuropathol Commun. 2021 May 26;9(1):99. doi: 10.1186/s40478-021-01185-8.
2020
The inhibition of cellular toxicity of amyloid-β by dissociated transthyretin
Cao Q, Anderson DH, Liang WY, Chou J, Saelices L
J Biol Chem 2020; 295, 12015-14024. doi: 10.1074/jbc.RA120.013440
Comparison of high-dose intracisterna magna and lumbar puncture intrathecal delivery of AAV9 in mice to treat neuropathies
Bailey RM, Rozenberg A, Gray SJ.
I. 2020 Jul 15;1739:146832. doi: 10.1016/j.brainres.2020.146832.
Alzheimer's disease risk modifier genes do not affect tau aggregate uptake, seeding or maintenance in cell models
Kolay S, Diamond MI.
FEBS Open Bio. 2020 Sep;10(9):1912-1920. doi: 10.1002/2211-5463.12928.
A synthetic heparinoid blocks Tau aggregate cell uptake and amplification
Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI.
J Biol Chem. 2020 Mar 6;295(10):2974-2983. doi: 10.1074/jbc.RA119.010353.
2019
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics
Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI.
J Biol Chem. 2019 Jan 18;294(3):1045-1058. doi: 10.1074/jbc.RA118.004471.
Propagation of Protein Aggregation in Neurodegenerative Diseases
Vaquer-Alicea J, Diamond MI.
Annu Rev Biochem. 2019 Jun 20;88:785-810. doi: 10.1146/annurev-biochem-061516-045049.
Tau local structure shields an amyloid-forming motif and controls aggregation propensity
Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak ŁA.
Nat Commun. 2019 Jun 7;10(1):2493. doi: 10.1038/s41467-019-10355-1.
2018
Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART
Kaufman SK, Del Tredici K, Thomas TL, Braak H, Diamond MI.
Acta Neuropathol. 2018 Jul;136(1):57-67. doi: 10.1007/s00401-018-1855-6.
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates
Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI.
J Biol Chem. 2018 Jul 6;293(27):10826-10840. doi: 10.1074/jbc.RA117.000378.
Inert and seed-competent tau monomers suggest structural origins of aggregation
Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak ŁA, Diamond MI.
Elife. 2018 Jul 10;7. pii: e36584. doi: 10.7554/eLife.36584.
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
Bardai FH, Ordonez DG, Bailey RM, Hamm M, Lewis J, Feany MB.
PLoS Biol. 2018 Dec 20;16(12):e2006265. doi: 10.1371/journal.pbio.2006265.
Development of Intrathecal AAV9 Gene Therapy for Giant Axonal Neuropathy
Bailey RM, Armao D, Nagabhushan Kalburgi S, Gray SJ.
Mol Ther Methods Clin Dev. 2018 Feb 15;9:160-171. doi: 10.1016/j.omtm.2018.02.005.
Tau monomer encodes strains
Sharma A, Thomas TL, Woodard DR, Kashmer OM, Diamond, MI.
eLife vol. 7 e37813. 11 Dec. 2018, doi:10.7554/eLife.37813.
2017
FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples
Furman JL, Diamond MI.
Methods Mol Biol. 2017;1523:349-359.
2016
Autonomic nervous system involvement in the giant axonal neuropathy (GAN) KO mouse: implications for human disease
Armao D, Bailey RM, Bouldin TW, Kim Y, Gray SJ.
Clin Autonom Res 2016 Aug;26(4):307-13. doi: 10.1007/s10286-016-0365-7.
Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo
Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI.
Neuron. 2016 Nov 23;92(4):796-812. doi: 10.1016/j.neuron.2016.09.055.