Publications


2022

RNA induces unique tau strains and stabilizes Alzheimer's disease seeds

Zwierzchowski-Zarate AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, White CL 3rd, Diamond MI.
J Biol Chem. 2022 Jun 11:102132. doi: 10.1016/j.jbc.2022.102132. Online ahead of print.

The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification

Kolay S, Vega AR, Dodd DA, Perez VA, Kashmer OM, White CL 3rd, Diamond MI.
J Biol Chem. 2022 May 5;298(6):102014. doi: 10.1016/j.jbc.2022.102014. Online ahead of print.

The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics

Wickramaratne AC, Li L, Hopkins JB, Joachimiak ŁA, Green CB.
Biochemistry. 2022 May 10. doi: 10.1021/acs.biochem.2c00072. Online ahead of print.

Modifying Amyloid Motif Aggregation Through Local Structure

Bali S, Joachimiak ŁA.
Methods Mol Biol. 2022 ;2340:343-356. doi: 10.1007/978-1-0716-1546-1_15.

Chaperoning shape-shifting tau in disease

Ryder BD, Wydorski PM, Hou Z, Joachimiak ŁA.
Trends Biochem Sci. 2022 Apr;47(4):301-313. doi: 10.1016/j.tibs.2021.12.009.

Return to top


2021

Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone

Ryder, BD, Matlahov, I, Bali, S, Vaquer-Alicea, J, van der Wel, PCA, Joachimiak, Ł.
Nat Commun 2021 12, 946. doi:10.1038/s41467-021-21147-x

Read News Release

Tau strains shape disease

Vaquer-Alicea, J, Diamond, MI, Joachimiak, Ł.
Acta Neuropathol 2021. doi: 10.1007/s00401-021-02301-7.

AAV9-mediated FIG4 delivery prolongs life span in Charcot-Marie-Tooth disease type 4J mouse model

Presa M, Bailey RM, Davis C, Murphy T, Cook J, Walls R, Wilpan H, Bogdanik L, Lenk GM, Burgess RW, Gray SJ, Lutz C.
J Clin Invest. 2021 Jun 1;131(11):e137159. doi: 10.1172/JCI137159.

Gene Transfer Therapy for Neurodevelopmental Disorders

Ozlu C, Bailey RM, Sinnett S, Goodspeed KD.
Dev Neurosci. 2021 ;43(3-4):230-240. doi: 10.1159/000515434.

Extensive rod and cone photoreceptor-cell degeneration in rat models of giant axonal neuropathy: implications for gene therapy of human disease

Armao D, Bouldin TW, Bailey RM, Gray SJ.
Ophthalmic Genet vol. 42,5 (2021): 600-603. doi:10.1080/13816810.2021.1923036

Biophysical properties of a tau seed

Hou, Z, Chen, D, Ryder, BD, Joachimiak, Ł.
Sci Rep 11, 13602 (2021). doi: 10.1038/s41598-021-93093-z

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

Hou Z, Wydorski PM, Perez VA, Mendoza-Oliva A, Ryder BD, Mirbaha H, Kashmer O, Joachimiak LA.
Nat Commun. 2021 Sep 9;12(1):5338. doi: 10.1038/s41467-021-25635-y.

Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns

Stopschinski BE, Del Tredici K, Estill-Terpack SJ, Ghebremdehin E, Yu FF, Braak H, Diamond MI.
Acta Neuropathol Commun. 2021 Oct 11;9(1):164. doi: 10.1186/s40478-021-01255-x.

Tau seeding in chronic traumatic encephalopathy parallels disease severity

Kaufman SK, Svirsky S, Cherry JD, McKee AC, Diamond MI.
Acta Neuropathol. 2021 Dec;142(6):951-960. doi: 10.1007/s00401-021-02373-5.

Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF

Hitt BD, Vaquer-Alicea J, Manon VA, Beaver JD, Kashmer OM, Garcia JN, Diamond MI.
Acta Neuropathol Commun. 2021 May 26;9(1):99. doi: 10.1186/s40478-021-01185-8.

Return to top


2020

The inhibition of cellular toxicity of amyloid-β by dissociated transthyretin

Cao Q, Anderson DH, Liang WY, Chou J, Saelices L
J Biol Chem 2020; 295, 12015-14024. doi: 10.1074/jbc.RA120.013440

Read News Release

Comparison of high-dose intracisterna magna and lumbar puncture intrathecal delivery of AAV9 in mice to treat neuropathies

Bailey RM, Rozenberg A, Gray SJ.
I. 2020 Jul 15;1739:146832. doi: 10.1016/j.brainres.2020.146832.

Alzheimer's disease risk modifier genes do not affect tau aggregate uptake, seeding or maintenance in cell models

Kolay S, Diamond MI.
FEBS Open Bio. 2020 Sep;10(9):1912-1920. doi: 10.1002/2211-5463.12928.

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI.
J Biol Chem. 2020 Mar 6;295(10):2974-2983. doi: 10.1074/jbc.RA119.010353.

Return to top


2019

Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics

Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI.
J Biol Chem. 2019 Jan 18;294(3):1045-1058. doi: 10.1074/jbc.RA118.004471.

Propagation of Protein Aggregation in Neurodegenerative Diseases

Vaquer-Alicea J, Diamond MI.
Annu Rev Biochem. 2019 Jun 20;88:785-810. doi: 10.1146/annurev-biochem-061516-045049.

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak ŁA.
Nat Commun. 2019 Jun 7;10(1):2493. doi: 10.1038/s41467-019-10355-1.

Return to top


2018

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART

Kaufman SK, Del Tredici K, Thomas TL, Braak H, Diamond MI.
Acta Neuropathol. 2018 Jul;136(1):57-67. doi: 10.1007/s00401-018-1855-6.

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates

Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI.
J Biol Chem. 2018 Jul 6;293(27):10826-10840. doi: 10.1074/jbc.RA117.000378.

Inert and seed-competent tau monomers suggest structural origins of aggregation

Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak ŁA, Diamond MI.
Elife. 2018 Jul 10;7. pii: e36584. doi: 10.7554/eLife.36584.

Read News Release

Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.

Bardai FH, Ordonez DG, Bailey RM, Hamm M, Lewis J, Feany MB.
PLoS Biol. 2018 Dec 20;16(12):e2006265. doi: 10.1371/journal.pbio.2006265.

Development of Intrathecal AAV9 Gene Therapy for Giant Axonal Neuropathy

Bailey RM, Armao D, Nagabhushan Kalburgi S, Gray SJ.
Mol Ther Methods Clin Dev. 2018 Feb 15;9:160-171. doi: 10.1016/j.omtm.2018.02.005.

Tau monomer encodes strains

Sharma A, Thomas TL, Woodard DR, Kashmer OM, Diamond, MI.
eLife
vol. 7 e37813. 11 Dec. 2018, doi:10.7554/eLife.37813.

Return to top


2017

FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples

Furman JL, Diamond MI.
Methods Mol Biol. 2017;1523:349-359.

Return to top


2016

Autonomic nervous system involvement in the giant axonal neuropathy (GAN) KO mouse: implications for human disease

Armao D, Bailey RM, Bouldin TW, Kim Y, Gray SJ.
Clin Autonom Res 2016 Aug;26(4):307-13. doi: 10.1007/s10286-016-0365-7.

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI.
Neuron. 2016 Nov 23;92(4):796-812. doi: 10.1016/j.neuron.2016.09.055.