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Research Tracks

More than 60 investigators with their laboratories commit to making a difference in kidney cancer. Below is a list of research areas with corresponding track investigators.

Behavioral Science

ResearcherResearch Topic
Chad Rethorst, Ph.D. Effects of fitness on mortality

Bioinformatics & Machine Learning

ResearcherResearch Topic
Gaudenz Danuser, Ph.D. Implications of mechanical and chemical cell shape regulation in migration and survival of the metastatic cell
Nick Grishin, Ph.D. Protein analysis using computational methods
Lisa Kinch, Ph.D. Prediction of protein structure and function from sequence, and exploration of fold changes in protein evolution
Bo Li, Ph.D. Novel computational and genomic approaches to study interactions between tumor and immune system
Jimin Pei, Ph.D. Development and application of computational methods for analysis of biological sequences and structures
Satwik Rajaram, Ph.D. Machine learning applied to tissue images, and intratumoral heterogeneity
Tao Wang, Ph.D. Bioinformatics and machine learning with a focus on cancer biology and immunology
Guanghua (Andy) Xiao, Ph.D. Statistical methods for genomics and proteomics, and spatial and image analysis
Yang Xie, Ph.D. Statistical genomics and prediction modeling
He Zhang, Ph.D. Cancer genomics and evolution

Back to TopClinical Sciences

ResearcherResearch Topic
Bijal Balasubramanian, M.B.B.S., Ph.D. Health care effectiveness and outcomes research
Simon Lee, Ph.D. Mixed-methods approaches to healthcare delivery research
Sandi Pruitt, Ph.D. Behavioral science, epidemiology, and health disparities research
Celette Skinner, Ph.D. Communication interventions to promote health
Jasmin Tiro, Ph.D. Multi-level intervention research directed at cancer prevention and early detection behaviors specifically among underserved populations

Development

ResearcherResearch Topic
Thomas Carroll, Ph.D. Segmentation and polarity
Ondine Cleaver, Ph.D. Vascular heterogeneity in the kidney; development of replacement kidneys
Christopher Lu, M.D. Hypoxia and development
Denise Marciano, M.D., Ph.D. Cell-cell interactions
Saikat Mukhopadhyay, M.D., Ph.D. Signaling at the primary cilium and its role in kidney development and disease
Eric Olson, Ph.D. Transcriptional regulation

Back to TopDrug Discovery and Development

ResearcherResearch Topic
James Brugarolas, M.D., Ph.D. Targeting genetically acquired vulnerabilities
Chuo Chen, Ph.D. Natural product synthesis and Hh/Wnt inhibitors
David Corey, Ph.D. Regulation of transcription, translation, and splicing by nucleic acids
J. Falck, Ph.D. Medicinal chemistry and total synthesis
Steven McKnight, Ph.D. Exploiting metabolic vulnerabilities in cancer
Bruce Posner, Ph.D. High-throughput cell-based screens
Joseph Ready, Ph.D. Synthetic chemistry
Michael Roth, Ph.D. High-throughput screening of chemical compound and siRNA libraries
Daniel Siegwart, Ph.D. Synthetic carriers for therapeutic delivery of small and large RNAs
Uttam Tambar, Ph.D. Natural product synthesis and medicinal chemistry
Noelle Williams, Ph.D. Pharmacokinetics and pharmacodynamic biomarkers
Yonghao Yu, Ph.D. Targeting mTORC1

Back to TopEpigenetics

ResearcherResearch Topic
Laura Banaszynski, Ph.D. Dynamic regulation of chromatin states at both coding and non-coding regions
Cheng-Ming Chiang, Ph.D. Epigenetic control of chromatin-dependent transcription
William Kraus, Ph.D. Signal-regulated gene expression
Xin Liu, Ph.D. Chromatin and nuclear organization, and structural biology
Ram Mani, Ph.D.  Epigenetic mechanisms in cancer
Jose Rizo-Rey, Ph.D. Structural biology
Hao Zhu, M.D. Nucleosome remodeling and cancer
Hong Zhu, Ph.D. Pharmacogenomics, pharmacogenetics, and genetic interactions

Back to TopGenomics

Research TrackResearch Topic
James Brugarolas, M.D., Ph.D. Molecular genetic determinants of aggressiveness and drug resistance
Kenneth Chen, M.D. miRNA biology in Wilms tumor
Payal Kapur, M.D. Morphometric analyses and underlying biology
Ivan Pedrosa, M.D., Ph.D. Molecular genetic determinants of biophysical signals captured by MRI
Dinesh Rakheja, M.D. Wilms tumor biology
Yang Xie, Ph.D. Statistical genomics and prediction modeling
Chao Xing, Ph.D. Statistical genetics and genetic epidemiology 

Back to TopHIF/VHL

ResearcherResearch Topic
James Brugarolas, M.D., Ph.D. Exploiting HIF-dependent metabolic reprogramming
Jin Jiang, Ph.D. Regulation of HIF-1 signaling
Christopher Lu, M.D. Hypoxia signal transduction in the mouse
Weibo Luo, Ph.D. Oxygen homeostasis in tumor growth and metastasis with a focus on HIFs
Steven McKnight, Ph.D. Post-translational regulation of HIF
Peter Michaely, Ph.D. HIF regulation by oncogenic events
Wanpen Vongpatanasin, M.D. Molecular mechanisms of TKI-induced hypertension

Back to TopImaging

ResearcherResearch Topic
Maddy Artunduaga, M.D. MRI-based imaging markers of renal cancer
Alberto Diaz de Leon, M.D. Improved imaging of genitourinary tract malignancies
David Fetzer, M.D. Quantitative and contrast-enhanced ultrasound imaging
Guiyang Hao, Ph.D. Molecular imaging probes for oncology
Kenneth Hoyt, Ph.D. Ultrasound technology for applications related to imaging of diseased tissue, therapy, and drug delivery
Ananth Madhuranthakam, Ph.D. Novel MRI tools for evaluation of renal masses
Ralph Mason, Ph.D. Hypoxia tracers
Ivan Pedrosa, M.D., Ph.D. Novel MRI tools for prognostication and prediction
Fangyu Peng, M.D., Ph.D. Altered metabolism as a target for kidney cancer imaging and therapy
Xiankai Sun, Ph.D. Multi-modality imaging and quantitative delineation of diseases status under treatment
Jing Wang, Ph.D. Image-guided radiation therapy
Takeshi Yokoo, M.D., Ph.D. Quantitative imaging biomarkers
Qing Yuan, Ph.D. Dynamic contrast-enhanced MRI

Back to TopImmunology

ResearcherResearch Topic
Esra Akbay, Ph.D. Immunotherapy and tumor microenvironment
Kiyoshi Ariizumi, Ph.D. Immune cell regulation in inflammation and cancer
Bruce Beutler, M.D. Signaling pathways in innate immune response
James Chen, Ph.D. Signaling pathways in innate immunity
Mingyi Chen, M.D., Ph.D. Cancer stem cells and tumor immunology
Lindsay Cowell, Ph.D. Dynamics of adaptive immune receptor repertoires
David Farrar, Ph.D. Cytokine regulation of adaptive immune response
Beatriz Fontoura, Ph.D. Cell biology of viral-host interactions
Yang-Xin Fu, M.D., Ph.D. Immunotherapy in cancer with a focus on next generation antibody-based molecules
Hans Hammers, M.D. Immunotherapy in cancer focusing on checkpoint inhibitors
Wen Jiang, M.D., Ph.D. How cancer cells evade immune detection
Bo Li, Ph.D. Predictive biomarkers for cancer immunotherapies and new therapeutic targets
Andrew Sandstrom, Ph.D. Mechanisms of innate immune detection in host/pathogen interactions
Nan Yan, Ph.D. Regulation of the STING pathway in innate immunity

Back to TopMarkers

Research TrackResearch Topic
Payal Kapur, M.D. Discovery and application of prognostic and predictive tissue biomarkers
Vitaly Margulis, M.D. Circulating tumor cells
Dinesh Rakheja, M.D. Metabolites as cancer biomarkers
Yonghao Yu, Ph.D. Circulating biomarkers

Back to TopMetabolism

ResearcherResearch Topic
Shawn Burgess, Ph.D. Magnetic resonance spectroscopy
Kevin Courtney, M.D., Ph.D. Tracking tumor metabolism in humans
Ralph DeBerardinis, M.D., Ph.D. Abnormal metabolic fluxes in tumors
Sarah Huen, M.D., Ph.D. Renal metabolism in sepsis and other states of inflammation
Craig Malloy, M.D. Real-time metabolic imaging
Peter Michaely, Ph.D. Lipid metabolism and cancer
Ivan Pedrosa, M.D., Ph.D. Imaging metabolism in cancer
Dinesh Rakheja, M.D. Mutation-driven metabolic alterations in tumors
Dean Sherry, Ph.D. Metabolism tracing using stable isotopes in vivo
Jin Ye, Ph.D. Lipid metabolism in cancer

Back to TopMicrobiome

ResearcherResearch Topic
Andrew Koh, M.D. Role of microbiome in modulating host immune-mediated anti-tumor activity
Lora Hooper, Ph.D. Intestinal bacteria influence on the biology of humans and other mammalian hosts
Sebastian Winter, Ph.D. Microbiota imbalance and cancer
Hasan Zaki, Ph.D. Effect of gut microbiota on inflammation and tumorigenesis

Back to TopmTOR

ResearcherResearch Topic
James Brugarolas, M.D., Ph.D. Regulation and function of mTORC1 and its effector TFEB
Thomas Carroll, Ph.D. mTOR signaling in kidney development
Joseph Hill, M.D., Ph.D. Cell growth control
Jenna Jewell, Ph.D. Mechanism of nutrient sensing and cell growth regulation by mTORC1
Beth Levine, M.D. Functions of autophagy in health and disease
Peter Michaely, Ph.D. Cytoskeletal regulation of Akt/mTOR signaling
Benjamin Tu, Ph.D. Interplay of cell growth and metabolism in yeast
Yonghao Yu, Ph.D. Cell growth control

Back to TopPediatric Kidney Tumors

ResearcherResearch Topic
Thomas Carroll, Ph.D. Modeling Wilms tumors in the mouse
Kenneth Chen, M.D. Wilms tumor biology
Keri Drake, M.D. Wilms tumor cell of origin
Joshua Mendell, M.D., Ph.D.  MicroRNA dysregulation in Wilms tumor
Khushbu Patel, M.D. Biomarkers for Wilms tumor 
Dinesh Rakheja, M.D. Wilms tumor biology
Jonathan Wickiser, M.D. Targeting pediatric renal tumors

Back to TopQuantitative Research

ResearcherResearch Topic
Chao Xing, Ph.D. Statistical genetics and genetic epidemiology
Song Zhang, Ph.D. Adaptive clinical trial designs
Hong Zhu, Ph.D. Clinical trials, bioinformatics, and statistical genetics

Back to TopRadiation Biology

ResearcherResearch Topic
Benjamin Chen, Ph.D. Radiation biology and DNA repair
Aurelie Garant, M.D. Radiation resistance and immune priming
Raquibul Hannan, M.D., Ph.D. Radiation immunobiology

Back to TopSignaling/Metastasis

ResearcherResearch Topic
John Abrams, Ph.D. Apoptosis in model organisms
Joseph Albanesi, Ph.D. Secretory vesicle biogenesis and trafficking
Rolf Brekken, Ph.D. Tumor angiogenesis
Maralice Conacci-Sorrell, Ph.D. Transcriptional regulation in tumor growth and development
Ivan D'Orso, Ph.D. Transcriptional-epigenetic programs in cancer
Nick Grishin, Ph.D. Protein modeling
Jer-Tsong Hsieh, Ph.D. Nanomedicine
Lily Huang, Ph.D. Cytokine signaling
Khuloud Jaqaman, Ph.D. Cell surface receptor organization and signaling in angiogenesis
Srinivas Malladi, Ph.D. Invasion and metastasis
Joshua Mendell, M.D., Ph.D. MicroRNAs in cancer
Saikat Mukhopadhyay, M.D., Ph.D. Signaling at the primary cilium and its role in kidney development and disease
Peter Michaely, Ph.D. Cytoskeletal control of ERK/Akt signaling
Duojia (D.J.) Pan, Ph.D. Size-control mechanisms in normal development and their pathological roles in cancer
Yihong Wan, Ph.D. Metastatic bone niche
Qing Zhang, Ph.D. VHL substrates in RCC development

Back to TopTechnological Innovation

ResearcherResearch Topic
Jeffrey Cadeddu, M.D. Robotic surgery and ablative techniques
Vitaly Margulis, M.D. Robotic surgery and ablative techniques
Ivan Pedrosa, M.D., Ph.D. Spectral and novel anatomic and functional imaging
Arthur Sagalowsky, M.D. Advanced surgical techniques