New test uncovers metabolic vulnerabilities in kidney cancer
KCP researchers develop a novel approach using intraoperative infusions of labeled glucose to assess RCC tumor metabolism. These findings may open up new opportunities for therapeutic intervention. Press Release
UTSW scientists identify new mechanisms underlying pediatric kidney cancer
Kidney SPORE investigators Dr. Jim Amatruda and Dr. Josh Mendell report their follow-up studies on the role of microRNAs in Wilms tumor, the most common cancer of the kidney in children. In separate papers, Dr. Amatruda's group and Dr. Mendell's group report on different mechanisms of IGF2 regulation. Press Release
UTSW’s Kidney SPORE awards 8 recipients with DRP/CEP funding to support innovative kidney cancer research
Eight outstanding awardees will be supported as part of SPORE Year 3 Developmental Research and Career Enhancement Programs (DRP and CEP). The DRP awardees are: Drs. Srinivas Malladi, Chad Rethorst, and Tao Wang. CEP awards went to Drs. Alberto Diaz de Leon, Keri Drake, Nick Grishin, Jin Jiang, and Ram Mani. Research proposal topics ranged from identifying determinants of metastatic latency to whole body detection of osseous metastases to identifying the cell origin of Wilms tumor.
Two UT Southwestern investigators awarded $30K grants from Action to Cure Kidney Cancer
ACKC, a kidney cancer grassroots advocacy organization, donated funds to the KCP to award grants to attract new investigators to the kidney cancer field. The ACKC “fellows” are Sarah Huen, M.D., Ph.D., Assistant Professor in Internal Medicine, and Kiyoshi Ariizumi, Ph.D., Professor in Dermatology. Their proposals focus on cachexia and immunotherapy, respectively, in renal cell carcinoma.
UTSW researchers identify novel mechanism in innate immunity signaling
Work from Dr. James Chen's lab published in Science demonstrates that cGAS binds with DNA to form droplets that act as tiny bioreactors creating molecules to stimulate innate immunity – the body’s first response to infection. Press release
UTSW recognized as a VHL Clinical Care Center
The VHL Alliance recognizes UT Southwestern as a VHL Clinical Care Center, one of 21 in the US, and the only one in North Texas. VHL, or von Hippel-Lindau disease, is a genetic/familial condition characterized by mutation in the VHL gene and a predisposition to kidney cancer. These centers are committed to providing outstanding holistic, coordinated care for VHL patients.
KCP researchers leverage extensive RCC tumorgraft platform to understand the tumor microenvironment
Drs. Wang and Brugarolas report an empirical approach using tumorgraft models and a computational program called DisHet to dissect the tumor microenvironment. Press Release
SPORE Career Development Awardee, Dr. Banaszynski, is awarded a Kidney Cancer Research Program Early-Career Investigator Award
Dr. Laura Banaszynski was selected as one of the funding recipients of the first national Kidney Cancer Research Program awards. The title of her application is "Chromatin Dysregulation and Metabolism Disorder in Kidney Cancer".
Drs. Margulis and Wait lead consortium to refine markers of prognosis in invasive kidney cancer
Dr. Vitaly Margulis, Associate Professor of Urology, and Dr. Michael Wait, Professor of Cardiovascular and Thoracic Surgery, lead a research team of top-tier investigators from Mayo Clinic, MD Anderson Cancer Center, Emory University, Indiana University, and the University of Wisconsin to help identify factors that can affect kidney cancer recurrence following surgery. Manuscript • Press Release
Dr. DeBerardinis named Howard Hughes Medical Institute investigator
Dr. Ralph DeBerardinis, Professor at the Children’s Medical Center Research Institute at UT Southwestern (CRI), becomes UT Southwestern's latest Howard Hughes Medical Institute (HHMI) Investigator, bringing the total number of HHMI investigators to 15. Dr. DeBerardinis is Chief of the Division of Pediatric Genetics and Metabolism at UT Southwestern and an attending physician at Children’s Health. He is also a Professor of Pediatrics and member of the Eugene McDermott Center for Human Growth and Development. Dr. DeBerardinis serves as a KCP Co-Leader, Metabolism, and is a kidney SPORE project leader. Press Release