Collaborative study highlights imortance of complement system in renal cancer
A collaborative study with Texas Tech University Health Sciences Center that builds upon a prior KCP discovery of an inflammed subtype of renal cancer (Wang et al., Cancer Discov 2018) shows increased deposition of complement proteins in inflamed renal tumors. The data suggest that complement proteins, which are associated with poor prognosis, may suppress an adaptive immune response and could be targeted in combination with immune checkpoint inhibitors.
CDMRP-funded National Kidney Cancer Academy hosts meeting for new investigators
November 5 marks the first workshop for kidney cancer investigators participating in the National Kidney Cancer Academy, funded by the CDMRP's (Congressionally Directed Medical Research Program) Kidney Cancer Research Program. New investigator award recipients Drs. David Braun (Dana-Farber Cancer Institute), Abishek Chakraborty (Cleveland Clinic), and Lucas Salas (Dartmouth Geisel School of Medicine) discussed their research plans with Dr. Brian Rini (Vanderbilt-Ingram Cancer Center), Dean of the Academy, along with members of the Advisory Board, which is chaired by KCP Director Dr. James Brugarolas, and other kidney cancer experts.
Novel ccRCC evolutionary model
Drawing from a recent report of ccRCC subtypes based on gene expression (from a Genentech-sponsored clinical trial), as well as pioneering genomic discoveries and mouse models from the Kidney Cancer Program, Drs. Brugarolas and Kapur present an updated evolutionary model of clear cell renal cell carcinoma development. Article
Discovery shows connection between autoimmune side effect and improved immunotherapy response for kidney cancer patients
In a newly published study, KCP investigators show a link between immune attacks against the kidneys and positive response rates to immunothrapy - a discovery which may hold implications for other cancers.
Dr. James Chen receives Cancer Research Institute Award for groundbreaking discoveries on innate immunity
Biochemist Dr. Zhijian "James" Chen receives the 2020 William B. Coley Award in recognition for his work on the cGAS-STING pathway and its potential to improve cancer immunotherapies.
T cells may hold key to detecting early-stage cancer
Dr. Bo Li, Assistant Professor of Bioinformatics at UTSW, and colleagues have developed a deep learning system designed to detect subtle changes in T cells as a means for recognizing cancer in its earlist stage, when it's most easily treated.
Joint KCP and Cleveland Clinic study shows how pancreatic spread influences course of treatment
Researchers at UT Southwestern and the Cleveland Clinic unveil unique biology of kidney cancer that metastasizes to the pancreas, noting how and why it responds to TKIs but not immunotherapy. Press Release
Simmons Cancer Center elected to National Comprehensive Cancer Network
As a member of the NCCN, UT Southwestern Medical Center's Simmons Cancer Center faculty join faculty from 30 other top cancer institutions in the U.S. to develop NCCN Clinical Practice Guidelines, a recognized standard for clinical cancer care. Press Release
Leading kidney cancer experts gather in Dallas for 6th annual EAB meeting
Members of the KCP Scientific Advisory Board meet with members of the SPORE Executive Committee and other KCP members to discuss research initiatives. Highlights of this year's meeting included the KCP SPORE renewal.
UT Southwestern investigators awarded funding for AI research
Dr. Vitaly Margulis, Professor of Urology, and Dr. Xiaosong Meng, Urologic Oncology Fellow, are among five recipients selected from four institutions - the National Institutes of Health, Thomas Jefferson University, M.D. Anderson Cancer Center and UT Southwestern Medical Center - to receive funding from the Kidney Cancer Research Alliance (KCCure) for groundbreaking kidney cancer research. Drs. Margulis and Meng are exploring the use of deep machine learning to identify aggressive tumor characteristics in renal cell carcinoma. Press Release