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Joint KCP and Cleveland Clinic study shows how pancreatic spread influences course of treatment


Researchers at UT Southwestern and the Cleveland Clinic unveil unique biology of kidney cancer that metastasizes to the pancreas, noting how and why it responds to TKIs but not immunotherapy. Press Release

Simmons Cancer Center elected to National Comprehensive Cancer Network


As a member of the NCCN, UT Southwestern Medical Center's Simmons Cancer Center faculty join faculty from 30 other top cancer institutions in the U.S. to develop NCCN Clinical Practice Guidelines, a recognized standard for clinical cancer care. Press Release

Leading kidney cancer experts gather in Dallas for 6th annual EAB meeting


Members of the KCP Scientific Advisory Board meet with members of the SPORE Executive Committee and other KCP members to discuss research initiatives. Highlights of this year's meeting included the KCP SPORE renewal.

UT Southwestern investigators awarded funding for AI research


Dr. Vitaly Margulis, Professor of Urology, and Dr. Xiaosong Meng, Urologic Oncology Fellow, are among five recipients selected from four institutions - the National Institutes of Health, Thomas Jefferson University, M.D. Anderson Cancer Center and UT Southwestern Medical Center - to receive funding from the Kidney Cancer Research Alliance (KCCure) for groundbreaking kidney cancer research. Drs. Margulis and Meng are exploring the use of deep machine learning to identify aggressive tumor characteristics in renal cell carcinoma. Press Release

RADVAX clinical trial among pioneering research spotlighted at ASCO GU 2020


Dr. Hans Hammers, KCP Co-Leader for Clinical Research, presents results from UT Southwestern's clinical trial combining dual immune checkpoint inhibitors and stereotactic ablative radiotherapy (SBRT) for metastatic kidney cancer at the Oral Abstract Session. The RADVAX trial, as it's known, uses SBRT as an in situ vaccine to improve the effectiveness of immunotherapy. Article

Tumor dependency on HIF-2 pathway may prove Achilles heel for kidney cancer


In a newly published study revealing the underlying efficacy of HIF-2 inhibitor drugs, investigators at UT Southwestern have discovered a potential Achilles heel for kidney cancer. Clinical trial findings identified a cancer core dependency on HIF-2, a protein complex that plays a key role in the activation of genes responsible for cancer growth. In response to the drug's ability to disable HIF-2, tumors developed a resistance in the form of a mutation in the protein binding pocket where the drug is delivered, thereby preventing access to it. The finding suggests the critical role HIF-2 plays in the progression of kidney cancer and the extent to which tumors will safeguard it. Press Release

Researchers identify promising new kidney cancer target


Recent KCP recruit, Dr. Qing Zhang, Associate Professor of Pathology, and colleagues identify a selective vulnerability in VHL-mutant kidney cancer cells that could be exploited for therapy. Press Release

D Magazine Innovation Awards ceremony


Dr. James Brugarolas represents the Kidney Cancer Program at the inaugural Innovation Awards event, hosted by D Magazine and DCEO. The KCP was among five finalists recognized for Innovation in Healthcare. In total, 47 North Texas companies, organizations and entrepreneurs were honored across 13 award categories. (Image: Dr. James Brugarolas, director of the Kidney Cancer Program, with Gillea Allison, president of D Magazine Partners.)

KCP hosts 3rd annual retreat for trainees


The 3rd Annual Kidney Cancer Program Retreat, held at the UT Southwestern Faculty Club, brought together more than 30 medical students, interns, and residents to learn about research opportunities available with the KCP. The retreat, which was organized by Drs. Alex Bowman, Xiaosong Meng, and Roy Elias, featured presentations by early stage faculty who were previous KCP trainees and highlighted resources available through the Program. Sherwin Kelekar, an M.D., Ph.D. student in Dr. Ralph DeBerardinis' lab, and Dr. Alexander Kenigsberg, a 3rd-year urology resident, received a $1,000 prize for best poster in the medical student and resident categories, respectively. 

Novel classification of kidney cancer refines diagnosis


UT Southwestern investigators have developed an innovative framework for classifying renal cancer. Based on extensive analyses of tumor architecture, cytology, and microenvironment, Dr. Payal Kapur and colleagues defined 33 parameters for clear cell RCC (ccRCC) according to which they developed a classification for nine subtypes of the disease. The findings, published in EBioMedicine, represent the first comprehensive catalog of ccRCC, the most common type of kidney cancer. By applying mathematical models and a co-occurring matrix with superimposed vectorial processes based on tumor size and grade, investigators developed the first morphology-driven evolutionary model of the disease. Press Release