CSB Seminar - Dr. Roy Wollman

Please join us for a CSB Seminar, Monday, June 18, 2018 at 11 a.m. ‐ noon in ND11.218. A meet-the-speaker lunch will follow each seminar in the ND11 atrium.

Roy Wollman, Ph.D.
University of California, Los Angeles
Monday, June 18, 11 a.m.

Cellular Variability and Information Flow in Signal Transduction Networks

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The Wollman lab measures, models, and manipulates signaling activities at the single-cell level to understand Dynamic Cellular Information Processing. We strive to understand cellular decision-making, biological variation, and biological noise using multidisciplinary approaches. We develop methods in single-cell fluorescence microscopy in combination with computational image analysis to evaluate the distribution of cellular responses in real-time. We use mathematical modeling based on signaling pathway mechanisms to infer and predict the details of mechanistic cellular signaling. We experimentally investigate a cellular signaling system by manipulating the internal and external cellular environment both spatially and temporally at the single-cell level. Specific approaches include microfluidic devices, genetic and pharmaceutical perturbations, and optogenetics.