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UTSW Monoclonal Antibodies Available for Non-Exclusive Licensing

Internal Case NumberTitleLead ScientistPublication
0350 Monoclonal anti-human IL-6 Receptor antibody (UV4) Ellen S. Vitetta A Monoclonal Anti-Human IL-6 Receptor Antibody Inhibits the Proliferation of Human Myeloma Cells. Hybridoma 1993 Oct, 12 (5): 621-30. PMID: 8300137.
0372 Monoclonal antibodies to Sterol Regulatory Elements Binding Proteins (SREBP) 2A4 & 1C6 Michael S. Brown,
Joseph L. Goldstein		 SREBP-2, a Second Basic-helix-loop-helix-leucine Zipper Protein that Stimulates Transcription by Binding to a Sterol Regulatory Element. Proc. Natl. Acad. Sci. U.S.A., Vol. 90, pp. 11603-11607, December 1993, Biochemistry.
1125 Monoclonal antibodies to heavy- and light-chain kinesin: H1, H2, L1 and L2 George S. Bloom Monoclonal Antibodies to Kinesin Heavy and Light Chains Stain Vesicle-like Structures, but not Microtubules, in Cultured Cells. J Cell Biol 1989 Apr; 108 (4) 1453-63.
1129 Anti-rat monoclonal antibody to Myogenin Woodring E. Wright Monoclonal Antimyogenin Antibodies Define Epitopes Outside the bHLH Domain where Binding Interferes with Protein-Protein and Protein-DNA Interactions. Dev Genet. 1996;19(2):131-8.
1292 Monoclonal antibody to human CD14 (61D3) J. Donald Capra Human CD14 Mediates Recognition & Phagocytosis of Apoptotic Cells. Nature, Vol 392, 2 April 1998.
1391 Mouse monoclonal antibody for LDLR (C7) Michael S. Brown,
Joseph L. Goldstein		 Stoichiometric Binding of Low Density Lipoprotein (LDL) and Monoclonal Antibodies to LDL Receptors in a Solid Phase. Assay.J. Biol. Chem., Vol. 264, No. 16, Issue of June 5, pp. 9533-9538, 1989.
1437 Mouse monoclonal antibody 58K-9, Golgi specificity George Bloom A Novel 58-kDa Protein Associates with the Golgi Apparatus and Microtubules. J Biol Chem, 264, 16083-16092 (1989)
1547 Monoclonal antibody anti-SCAP (9D5) Michael S. Brown,
Joseph L. Goldstein		 Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein. J Biol Chem. Vol. 272, No. 32, Issue of August 8, pp.20213-20221, 1997.
1548 Mouse monoclonal antibody to very low density lipoprotein receptor VLDL-R (6A6) Michael S. Brown,
Joseph L. Goldstein		 Low Density Lipoprotein Receptor-related Protein Mediates Endocytosis of Monoclonal Antibodies in Cultured Cells and Rabbit Liver. J. Biol. Chem. Vol. 265, No. 34, Issue of December 5, pp. 21355-21362, 1990.
1550 Mouse monoclonal antibody against recombinant human Rab escort protein-1 (2F1) Michael S. Brown,
Joseph L. Goldstein

Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase. Science, New Series, Vol. 259, No. 5093 (Jan. 15, 1993), pp. 377-381.
1550-2 Mouse monoclonal antibody against the alpha subunit of human farnesyl transferase (IB7) Michael S. Brown,
Joseph L. Goldstein		 Mutational Analysis of alpha-Subunit of Protein Farnesyltransferase, Evidence for a Catalytic Role. J Biol Chem, Vol. 268, No. 2, Issue of January 15, pp. 1383-1390, 1993.
1718 Monoclonal antibodies to mouse Math1 protein Jane Johnson Autoregulation and Multiple Enhancers Control Math1 Expression in the Developing Nervous System. Development 127, 1185-1196 (2000).
1773 Mouse monoclonal antibody ATP-Binding Cassette Transporter G8 Helen Hobbs ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion. J Biol Chem. 2003 Nov 28;278(48):48275-82. Epub 2003 Sep 22.
1867 Mouse antibody with specificity for Human IgG (Heavy Chain) J. Donald Capra Initial Characterization of Monoclonal Antibodies Against Human Monocytes. Proc. Natl. Acad. Sci. U.S.A. Vol.77, No. 11, pp. 6764-6768, November 1980. Immunology.
2101 Monoclonal antibody against Cholesterol 24-Hydroxylase (1A7) David Russell

Neuronal Expression and Subcellular Localization of Cholesterol 24-hydroxylase in the Mouse Brain. J Comp Neurol. 2008 Apr 10;507(5):1676-93.
2702 IgG1-13G4, Niemann-Pick C2 Mouse Monoclonal Antibody Michael S. Brown Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells. Proc Natl Acad Sci U S A. 110(26):10580-5 (2013).
2935 lgG-A9 HMGCoA Reductase Antibody Joseph L. Goldstein Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe. J Biol Chem. 258(13):8450-5 (1983).
2936 lgG-HL 1 Human LDL Receptor Mouse Monoclonal Antibody Joseph L. Goldstein Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain. J Biol Chem 262(33):16127-34 (1987).
2989 lgG-22D5 Mouse SREBP-2 Antibody Guosheng Liang Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice. eLife 6: e25015 (2017).
3117 IgG-2B7 Rat LXR (Liver X Receptor) Mouse Monoclonal Antibody/Hybridoma Linda Donnelly Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex. Proc Natl Acad Sci U S A. 113(29): 8182–8187 (2016).
3346 Monoclonal Antibody for the Human A4B2 Nicotinic Acetylcholine Receptor Ryan Hibbs Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. Nature. 557(7704): 261–265 (2018).
3414 Mouse Monoclonal Antibodies Recognizing Cholesterol 25-Hydroxylase, An Enzyme Involved In Bile Acid Synthesis, Innate Immunity, and Regulation of Cholesterol Metabolism David W. Russell 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A. 106(39): 16764–16769 (2009).
3493 Monoclonal Antibodies to Mouse and Human PNPLA3 Jonathan Cohen The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation. Hepatology 66(4):1111-1124 (2017).
3598 Monoclonal Antibody Against the Human a1 GABAA Receptor Subunit Ryan Hibbs Structure of a human synaptic GABA A receptor. Nature 559(7712):67-72 (2018).
3681 Antibodies to TM6SF2 Helen H. Hobbs Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins. J Biol Chem. 291(20): 10659–10676 (2016).
3862 IgG-2G10 Hamster Scap Mouse Monoclonal Antibody/Hybridoma Arun Radhakrishnan Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis. Proc Natl Acad Sci U S A. 117(45):28080-28091 (2020).
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