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Welcome to the Division of Translational Research (DTR) in the Department of Internal Medicine at UT Southwestern Medical Center. The DTR was established to apply advanced technologies to biomedical discovery and diagnostic or therapeutic advances. Our mission remains focused on the development of new technologies and applications to solve biomedical problems. |
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We are committed to interaction with basic and clinical investigators within the Department of Internal Medicine and other UT Southwestern departments to leverage our expertise in the battle against human diseases. Our faculty share backgrounds in organic and physical chemistry and a desire to employ physical and chemical strategies to study biomedical problems. We are located on NC7 and NC8 on the North Campus. We participate in the training of graduate students and postdoctoral scientists, and we collaborate with several divisions in the Department of Internal Medicine, including Hematology/Oncology, Cardiology, Digestive Diseases, and Endocrinology/Metabolism.
The scope of our faculty’s research interest includes:
Phage display technology, to identify tumor-specific peptides for cancer treatment and imaging;
Peptoid arrays for micro-RNA manipulation in cardiac development and remodeling and in carcinogenesis;
Glycobiology, including the design and deployment of sugar analogs to identify low-affinity glycan interaction partners;
Top-down proteomics, advanced mass spectrometry methods to characterize post-translational modifications (PTMs) on important proteins in specific diseases;
Mass spectrometry profiling of steroid hormones, to improve diagnosis of diseases causing hypertension and infertility.
The DTR also incorporates the UT Southwestern Protein Chemistry Technology Core Facility, directed by Dr. Haydn Ball, which provides the UT Southwestern and North Texas research community with peptide synthesis and mass spectrometry services. We are delighted to showcase the 2010 acquisition of a Thermo Scientific LTQ Velos Orbitrap fourier transform mass spectrometer with electron transfer dissociation (ETD), facilitating fragmentation required to define PTMs and obtain detailed sequencing information. More information can be found on the Protein Chemistry Technology Core website.
We invite you to explore our website, learn about our faculty and their research programs, and consider the opportunities for working with our people. Technology remains the key to our future—including biology and medicine—and the DTR is committed to remain at the forefront in biomedical technology.
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