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| Jekyll and Hyde effect: Protein can nurture — or ravage — cells |
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Psychiatry researcher Dr. James Bibb (right) and radiologist Dr. Peter Antich used a dual modality imaging device in their study of Cdk5.
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Researchers at
UT Southwestern have uncovered new insights into the “Dr. Jekyll and Mr. Hyde” nature of a protein that stimulates stem-cell maturation in the brain but, paradoxically, can also lead to nerve-cell damage. In two separate studies in mice scheduled to appear online this week and in an upcoming issue of the Proceedings of the National Academy of Sciences,
UT Southwestern research teams studied the protein Cdk5 and discovered both helpful and detrimental mechanisms it elicits in nerve cells. Read More
Drug developed on campus shows promise for antiviral use
Bavituximab, an antiviral drug developed by UT Southwestern researchers, shows promise as a new strategy to fight viral diseases, including potential bioterrorism agents. Read More
'Deranged calcium signaling' may advance neurological disorder
Defective calcium metabolism in nerve cells may play a major role in a fatal genetic neurological disorder that resembles Huntington’s disease, researchers at UT Southwestern have found in a mouse study. Read More
Collagen protein might explain development of 'healthy' obesity
Mice whose fat cells were allowed to grow larger than fat cells in normal mice developed “healthy” obesity when fed a high-fat diet, researchers at
UT Southwestern found in a new study. Read More
Gene mutation is linked to inherited form of fatal lung disease
Researchers at UT Southwestern Medical Center have determined that a mutation in a gene known for its role in defending the lungs against invading pathogens is responsible for some inherited cases of a lethal lung disease affecting older adults. The same mutation may also be associated with lung cancer, the researchers said. Read More
Scientists pinpoint memory 'buffer' important to temporary information
Individual nerve cells in the front part of the brain can hold traces of memories on their own for as long as a minute and possibly longer, researchers at
UT Southwestern have found. Read More
Interferon 'reminds' cells how to defeat a virus
Scientists at UT Southwestern have determined that the immune-system protein interferon plays a key role in “teaching” the immune system how to fight off repeated infections of the same virus. Read More
Research Studies
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