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Program Chair: Yi Liu
Ilya Bezprozvanny - Neuronal calcium signaling and neurodegeneration, molecular mechanisms of Huntington's and Alzheimer's disease, calcium channels and synaptic transmission.
Rolf A. Brekken - Tumor-host interactions in pancreatic cancer as an avenue for the development of novel therapy; interplay between neoplastic genetic alterations, changes in the extracellular matrix, and angiogenesis in the development and progression of pancreatic cancer; gene therapy to restore SMAD4 expression in tumor cells; blocking VEGF-induced angiogenesis in tumors; function of the matricellular protein SPARC in tumor development.
Michael S. Brown - Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular and whole body levels.
Stephen C. Cannon - Ion channel biophysics; neuromuscular disorders; mathematical modeling.
Benjamin Chen - DNA Damage Response and DNA Double Strand Break Repair.
Zhijian (James) Chen -- Mechanisms and pathways of ubiquitin signaling, especially in regard to immunity and cancer.
Melanie H. Cobb - Function and regulation of protein kinases in signal transduction pathways.
George N. DeMartino - Cell physiology; regulation of growth and atrophy; protein degradation; intracellular proteases; ubiquitin/proteasome pathway of protein degradation.
J. Michael DiMaio - Collaborator of the LCBCC Consortium-University of Texas SPORE in Lung Cancer; Reynolds Associate with Reynolds Center-New Measures to reduce death and disability from ASHD
Amelia J. Eisch - Adult mammalian neurogenesis and growth factors; cell cycle analysis of adult neural stem cells in vivo; regulation of endogenous cell cycle proteins in psychiatric disorders such as addiction, depression and Alzheimer’s disease; transgenic manipulation of adult mammalian neurogenesis.
Joel Elmquist -- Functional neuroanatomy of the mammalian hypothalamus.
Errol C. Friedberg - Cellular responses to DNA damage and their relationship to neoplasia.
Christine Garcia -- Genetic approaches to identify primary determinants of lung disease.
Joseph Garcia - Integrative biological studies of hypoxia-inducible transcription factors; identification of genetic factors controlling the cardiovascular-respiratory response to hypoxia.
Vidu Garg - Genetics of congenital heart disease; 22 q11 deletion syndrome; cardiac development.
William T. Garrard - Regulation of the terminal stages of apoptosis in the nucleus; regulation of gene expression, chromatin structure and V(D)J recombination of antibody genes.
Dwight C. German - Mechanisms of neurodegeneration in neurological and psychiatric disorders, using human post-mortem tissue and animal models.
Joseph L. Goldstein - Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular and whole body levels.
Frederick Grinnell - Cell signaling during wound repair; cell motility and contractility in wound contraction; MAP kinase and other signaling pathways regulating cellular reorganization of collagen matrices stimulated by platelet-derived growth factor, lysophosphatidic acid and transforming growth-factor beta.
Lisa Marie Halvorson - Anterior Pituitary Gland Function; Reproductive Aging; PACAP in Reproduction
Stephen R. Hammes - Analysis of nongenomic steroid signaling; progesterone mediated maturation of oocytes.
Joachim J. A. Herz - Molecular genetics; genetic manipulation of neuronal apoE receptors in mice; mechanisms of brain development, neurogenesis and Alzheimer’s disease.
Joseph A. Hill - Molecular signaling processes in cardiac hypertrophy and failure; mechanisms of structural, functional and electrophysiological remodeling, using genetic and surgical mice models.
Sandra L. Hofmann - Role of lipid-metabolizing enzymes in cell metabolism and signal transduction; covalent modification of proteins by the fatty acid palmitate; the study of enzymes that transfer the palmitate on and off modified proteins.
Jay Horton - Hepatic steatosis; lipid metabolism.
Chou-Long Huang - Ion channels related to renal physiology and diseases, including renal potassium channel ROMK, epithelial calcium channel, and polycystic kidney disease protein related channels.
Peter Igarashi - Transcriptional control of tissue-specific gene expression and organogenesis; polycystic kidney disease.
Leighton R. James - Understanding interaction of glucose disposal pathways (like the hexosamine pathway) and cytokines (e.g. connective tissue growth factor, CTGF) in the pathogenesis of diabetic kidney disease using gene-targeted mice models and cells (mesangial cells, embryonic fibroblast) derived from these lines to study in vivo and in vitro mechanism(s) of progressive kidney disease due to diabetes.
Kristine E. Kamm - Muscle physiology; regulation of contractile and motile processes in smooth and nonmuscle cells.
Steven G. Kernie - Role of stem cells in brain remodeling following traumatic injury using both an in vivo injury model and in vitro techniques of culturing neural stem cells from wild type and genetically altered mice.
Makoto Kuro-o -- Molecular biology of aging.
Guoshen Liang - Cholesterol homeostasis; metabolic diseases such as obesity and diabetes; transcriptional regulation.
Yi Liu - Molecular mechanisms of circadian clocks.
Mala Mahendroo - Parturition (the process of labor); Cervical Ripening; Reproductive Biology (male and female)
David J. Mangelsdorf - Mechanism of action of nuclear hormone receptors; transcriptional regulation of lipid metabolism; role of retinoids and cancer.
Steven McKnight - Subset of transcription factors that are gene-specific; regulation of transcription-factor function at a biochemical level with keen attention to biological relevance.
Carole R. Mendelson - Molecular mechanisms in tissue-specific, developmental and hormonal regulation of eukaryotic gene expression.
Orson Moe - Regulation of mammalian water and electrolyte homeostasis, including sodium, calcium and acid-base metabolism and epithelial transport.
Lisa Monteggia - Development of animal models for psychiatric diseases; growth factors and depression; role of MeCP2 in mediating autistic-like behavior; transcriptional repression in neurons.
Shmuel Muallem - Ca2 signaling and ion transport in secretory cells.
Eric N. Olson - Transcriptional control of cell differentiation; muscle development.
Keith L. Parker - Gene regulation of steroidogenic tissue differentiation; nuclear hormone receptors; hypothalamic obesity.
Juan Pascual - Animal and cellular models of neurogenetic disorders. Synaptic transmission in experimental epilepsies. Disorders of brain energy metabolism. Developmental neurobiology. Genotype:phenotype correlations in novel childhood encephalopathies. Clinical pediatric neurology.
Joyce Repa - How nuclear receptors control the expression of ABC transport proteins and the consequences of this regulation on lipid balance with respect to atherosclerosis, diabetes and brain physiology.
Charles Rosenfeld - Cardiovascular adaptation during development and pregnancy; maturation and ontogeny of visceral and vascular smooth-muscle protein expression and function; regulation and function of angiotensin II receptor subtypes during development and pregnancy; mechanisms related to estrogen-induced vasodilation and modulation of uteroplacental blood flow in pregnancy.
Philipp Scherer - Identification and physiological characterization of novel secretory proteins that serve as potential links between the adipocyte and the processes of whole body energy homeostasis, inflammation and cancer, thereby defining novel targets for pharmacological intervention and further defining the role of adipose tissue as an endocrine organ.
Margaret Schwarz - Developmental pulmonary vascular biology interactions with distal lung morphogenesis and extracellular matrix deposition. Identification of the factors that govern the contradictory proliferative / antiangiogenic roles of endogenous negative vascular regulators during development.
Philip W. Shaul - Endothelial cell biology, vascular development and disease; signaling molecules in endothelial cell caveolae/lipid rafts.
Jerry W. Shay - Defining the molecular mechanisms of cellular aging.
William J. Snell - Understanding the mechanisms of cell-cell adhesion induced signaling and cell-cell fusion during fertilization.
James T. Stull - Myosin phosphorylation in the actin cytoskeleton and cell motility; modulation by signal-transduction pathways involving Ca2 and small GTP-dependent proteins.
Malú G. Tansey - Role of TNF and neuroinflammation in neurodegenerative diseases; neural progenitors in adult tissues.
Philip J. Thomas - Function and structural development of ATP-dependent membrane proteins, including CFTR.
Benjamin Tu - Metabolic oscillation and the mechanisms by which cellular processes are coupled to cyclic changes in metabolic or redox state in time.
Roger H. Unger - Diabetes; obesity; lipotoxicity; internal medicine; islet physiology and pathophysiology.
Steven Vernino -- Animal models of autoimmune autonomic neuropathy; serologic evaluation of patients with dysautonomia; disorders of neuromuscular hyperexcitability; paraneoplastic neurological syndromes.
Ronald G. Victor - Neurogenic reflexes; hypertension; syncope (vasodepressor).
Xiaodong Wang - Biomedical studies of apoptosis.
Keith A. Wharton - Pattern formation in development and disease; regulation Wnt signaling by naked proteins.
Thomas M. Wilkie - G-protein signaling during mouse development; energy homeostasis and feeding behavior.
Hiromi Yanagisawa - Molecular components of the vascular wall during development and disease.
Masashi Yanagisawa - Identification and characterization of new signaling molecules that regulate vital functions such as sleep, appetite and blood pressure.
Jin Ye -- Host proteins required for hepatitis C virus replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis.
Helen L. Yin - Actin cytoskeletons of nonmuscle cells, including reorganization in response to extracellular signals; structure/function relationships of the gelsolin family of actin regulatory proteins.
Chengcheng (Alec) Zhang - Mechanisms by which the cell fates of adult stem cells are regulated, and the interaction of adult stem cells and their in vivo microenvironment; ex vivo expansion of HSCs for cell therapy and gene therapy; the interplay between stem cells and cancer.
Jeffrey M. Zigman - Identification of CNS targets of ghrelin action; the study of ghrelin cell physiology; functional neuroanatomy of the mammalian hypothalamus.
Andrew R. Zinn - Human genetic diseases; infertility, obesity, sex chromosome abnormalities.
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