Cancer Biology Training Track Faculty

Track Chair: Jerry Shay

James Amatruda -- Defining novel cancer genes and understanding the developmental biology of tumors using the zebrafish system.

Robert Bachoo -- Molecular mechanisms underlying brain tumors

David Boothman -- Low dose radiation and cancer.

Rolf A. Brekken -- Tumor-host interactions in pancreatic cancer.

Kathlynn Brown -- Development of tumor targeting reagents for drug delivery and molecular imaging.

James Brugarolas -- Molecular mechanisms of cell growth and proliferation control.

Richard Bruick -- Regulation of the mammalian hypoxic response pathway in cancer.

Sandeep Burma -- DNA damage by gamma rays and galactic cosmic rays - signaling, repair and the cancer connection.

Scott Cameron -- Cell lineages and programmed cell death.

Diego Castrillon -- PI3K / PTEN / AKT / FoxO pathways in cancer biology.

David Chen -- Radiation biology and  DNA damage signaling.

Melanie H. Cobb -- Function and regulation of protein kinases in signal transduction pathways in breast cancer.

David R. Corey -- Cancer therapeutics: Engineering proteins and nucleic acids for novel function.

Jef De Brabander -- Synthesis of natural products and other molecular architectures and interrogation of their mode-of-action using molecular pharmacology and biochemistry for the development of novel cancer therapeutics.

Errol C. Friedberg -- Cellular responses to DNA damage in eukaryotic cells with emphasis on cancer-prone human hereditary diseases.

Jinming Gao -- Nanoparticles for cancer therapeutic drug delivery.

Harold R. (Skip) Garner, Jr. -- Automation and instrumentation for genomics research; DNA sequence analysis; computational biology.

Robert E. Hammer -- Transforming growth factor beta signaling.

Jer-Tsong (J.T.) Hsieh -- Human cancer gene therapy; signaling defects in urogenital cancers.

Lily Huang -- Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer.

Jin Jiang -- Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes.

Beth Levine -- Role of autophagy in tumor suppression.

Qing Richard Lu -- Neural stem cell differentiation in CNS; glial development in CNS; oligodendrocyte myelination and neurological diseases.

Lawrence Lum -- How information from multiple signaling molecules, including Hh and Wg, integrate in development and cancer.

Ralph Mason -- Animal imaging in cancer.

Steven McKnight -- Molecular genetics and biochemical studies of mammalian gene regulation.

John Minna -- Molecular pathogenesis of human cancer; signal transduction in human tumors; cancer stem cells; targeted cancer therapy.

Jerry Y. Niederkorn -- Immune surveillance of intraocular tumors; immune modulation of cancer metastases.

Chaitanya Nirodi -- The role of receptor tyrosine kinases in the repair of radiation-induced DNA damage

Luis F. Parada -- Mechanisms of neural development; trk receptors and neurotrophins; mouse models of neurological tumors.

Alexander Pertsemlidis -- MicroRNA regulation of lung cancer pathogenesis and genetic determinants of cardiovascular disease.

Matthew Porteus -- Regulation of DNA double-stranded break repair; regulation of homologous recombination in cancer.

Michael Roth -- High throughput screening for novel cancer therapeutics; recognition and sorting of cell-surface glycoproteins.

Pier Paolo Scaglioni  -- Characterization of the function of the PML tumor suppressor, mechanisms of K-RAS induced tumorigenesis, role of oncogene induced replicative senescence in tumor suppression, mouse models of lung cancer.

Richard H. Scheuermann -- Regulation of immunoglobulin gene expression; regulation of lymphocyte growth, development and apoptosis; lymphocyte receptor signal transduction; technology development; novel approaches to cancer therapy.

Roger A. Schultz -- Human genome instability, including Bloom and Roberts syndromes, centromere structure and function, and molecular evolution chromosome structure.

Jerry Shay -- Molecular mechanisms of human cellular aging and immortalization; the role of telomeres and telomerase in cancer.

Michael Story -- Radiation biology/oncology, cancer genomics, intrinsic radiosensitivity.

Philip Thorpe -- Development of novel angiogenesis inhibitors and agents for inducing thrombosis of tumor blood vessels for cancer treatment.

Jonathan Uhr -- Improving cancer treatment through: diagnosis at an earlier stage; analysis of cancer dormancy at the cellular and molecular levels; and targeted killing of human cancer cells in SCID mice by treatment with cell reactive monoclonal antibodies.

Ellen S. Vitetta -- The targeting of cytotoxic reagents to lymphoid cancers.

Xiaodong Wang -- Biochemistry of mammalian apoptosis, chemical synthesis of inhibitors of apoptosis for cancer therapy.

Michael White -- Molecular mechanisms for control of cell growth and differentiation.

Woodring E. Wright -- The role of telomeres and telomerase in cellular senescence and cancer.

Hongtao Yu -- Study of cell division cycle.

Yingming Zhao -- Functional proteomics and mass spectrometry in cancer.

Hui Zou -- Misregulation of chromatid cohesion and separation in cancer.