Postdoctoral Training Positions Available at UT Southwestern

• Advanced Imaging Research Center
  
  
• Biochemistry Department
  
  
• Cancer, Simmons Cancer Center
  
  
• Cardiology Divison, Internal Medicine
  
  
• Cell Biology
  
  
• Center for Human Nutrition
  
  
• Clinical Sciences
  
  
• Dermatology Department
  
  
• Developmental Biology Department
  
  
• Endocrinology
  
  
• Hematology Oncology, Internal Medicine
  
  
• Hypertension Division, Internal Medicine
  
  
• Immunology Department
  
  
• Infectious Diseases, Internal Medicine

• Microbiology
  
  
• Molecular Biology
  
  
• Nephrology
  
  
• Neurology
  
  
• Pathology
  
  
• Pharmacology
  
  
• Physiology
  
  
• Psychiatry
  
  
• Pulmonary, Internal Medicine
  
  
• Radiation Oncology
  
  
• Radiology
  
  
• Surgery, GI/Endocrine Division
  
  
• Urology
  

We are seeking an individual to carry out research in MR neuroimaging with state-of-art 3T and 7T clinical scanners and 7T and 9.4T animal scanners. Key areas of the research will be the following: investigation and development of diffusion tensor imaging and microimaging pulse sequences; in vivo and ex vivo animal imaging, image registration; MR digital brain atlas making; fiber tractography based on diffusion tensor images. Research is conducted to aid the diagnosis and treatment of neurological or psychiatric diseases and understand the mechanism of these diseases.

Candidate should have a Ph.D., M.D./Ph.D. or equivalent in Biomedical Engineering, Computer Science or Electrical Engineering; background in MR physics and image processing; strong programming skills with C, C , Matlab and IDL; strong communication skills in written and verbal English; and it would be helpful to have experience in working in the medical domain, specifically of medical imaging.

Send CV, description of research background and interests, and name of two references to:

Hao Huang, Ph.D.
Assistant Professor
Advanced Imaging Research Center
UT Southwestern Medical Center at Dallas
2201 Inwood Road, NE 3.204
Dallas, TX 75390
Phone: (214) 645-2881.
Email: Hao.Huang@UTSouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer

UT Southwestern is an Equal Opportunity, Affirmative Action Employer

Harold C. Simmons Comprehensive Cancer Center  

Postdoctoral Fellow in Cell Signaling and Metastasis (70)

Research Area: Cell Signaling, Metastasis and Genomic Instability

Description of project: A postdoctoral position is available to study cellular signaling networks required for cancer invasion and metastasis.  Current focuses are on the signal transduction processes required for IGF-1 ligand induction from DNA damage and genetic instability, as well as IGF-1R signaling pathways downstream. Cross-talk between IGF-1/TGF-b1/ATM signaling, and the role(s) of oxygen and glucose metabolism in clusterin regulation and cancer cell invasion and metastases are to be explored.

The prospective candidate will have the opportunity to work in a multi-disciplinary environment with a team of experts in basic and translational research, as well as high throughput genomic/proteomic technologies. Applicants should have a Ph.D. degree with strong background in cancer biology and molecular biology. 

Please email curriculum vitae (CV), names and contact information of three references to:

David A. Boothman, Ph.D.
Professor, Department of Pharmacology
Associate Director for Translational Research
Simmons Comprehensive Cancer Center
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas 75390-8807
e-Mail:  David.Boothman@UTSouthwestern.edu

Postdoctoral Fellow in Cell Stress and Cancer Nanomedicine (69)

Research Area: Nonsmall Cell Lung and Pancreatic Cancers, Molecular Signals of Noncaspase-mediated Cell Death, Cell Stress and Cancer Nanomedicine

Description of project: Two (2) post-doctoral positions are now open for researchers to develop nanoparticle systems to deliver a novel anti-tumor drug to two cancers (Nonsmall Cell Lung and Pancreatic cancers) that have elevated endogenous levels of the two electron oxidoreductase, NQO1. The studies involve delineating the roles of apoptosis inducing factor 1 (AIF1), GADPDH, µ-Calpain, b5R and P450R, as well as the roles of DNA base excision (BER) and DNA double strand break (DSB) repair systems in the efficacy of NQO1-expressing cancer cells/tumors to ß-lapachone. Pharmacokinetic and Pharmacodynamic studies will also be performed.

Prospective candidates will have the opportunity to work in a high productive multi-disciplinary environment with a team of experts in basic and translational research using novel nanotechnology delivery systems.

Applicants should have a Ph.D. degree with strong background in cancer biology and molecular biology. 

Please email curriculum vitae (CV), as well as names and contact information of three (3) references to:

David A. Boothman, Ph.D.
Professor, Department of Pharmacology
Associate Director for Translational Research
Simmons Comprehensive Cancer Center
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas 75390-8807
e-Mail:  David.Boothman@UTSouthwestern.edu

Molecular mechanisms and translational research in kidney cancer (19)

A postdoctoral position is available in the Brugarolas lab for entrepreneurial individuals pursuing a career in Academia who are interested in Cancer Biology.

The Brugarolas lab focuses on understanding kidney cancer. Specifically we are interested in:

1. Dissecting pathways involved in kidney cancer development, such as the mTOR pathway.
2. The discovery, using genomic platforms, of new pathways implicated in the pathogenesis of kidney cancer.
3. The development of novel paradigms for the evaluation of molecularly targeted therapies for kidney cancer.

To attain these goals, multiple approaches are utilized in the lab. Ongoing projects include: an RNAi screen of the Drosophila kinome, affinity chromatography studies to identify interacting proteins, genomic analyses of patient tumor samples, a synthetic lethal screen to identify tumor specific targets, molecular studies of drugs approved for use in patients with kidney cancer, as well as a variety of cellular and molecular biology projects. In addition, the laboratory works with several genetically engineered mouse models harboring mutations in various tumor suppressor genes including Vhl, Tsc1, Tsc2 as well as REDD1.

The laboratory offers an extraordinarily rich environment that encompasses both basic and translational research for highly motivated individuals interested in Cancer Biology.

For more information see: http://www4.utsouthwestern.edu/brugarolaslab/

Position requirements: candidates should hold an MD/PhD or PhD degree and be interested in a career in Academia.  

Interested individuals should send the following information:

1. A statement of interest explaining the reasons why the candidate is interested in the position and how the position might further the candidate’s career goals.
2. An updated CV.
3. Names and contact information for 3 professional references.

James Brugarolas, M.D., Ph.D.
Assistant Professor
c/o Bradley Hicks
Sr. Administrative Assistant
5323 Harry Hines Blvd.
Dallas, Tx 75390-9133
Bradley.Hicks@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer

Cardiology, Department of Internal Medicine 

There are no available positions at this time. 

UT Southwestern is an equal opportunity/affirmative action employer.

Cell Biology

There are no positions available at this time. 

Center for Human Nutrition

There are no positions available at this time.

Clinical Sciences

There are no positions available at this time.

Department of Dermatology

There are no positions available at this time. 

Developmental Biology Department

Molecular mechanisms and translational research in kidney cancer (19)

A postdoctoral position is available in the Brugarolas lab for entrepreneurial individuals pursuing a career in Academia who are interested in Cancer Biology.

The Brugarolas lab focuses on understanding kidney cancer. Specifically we are interested in:

1. Dissecting pathways involved in kidney cancer development, such as the mTOR pathway.
2. The discovery, using genomic platforms, of new pathways implicated in the pathogenesis of kidney cancer.
3. The development of novel paradigms for the evaluation of molecularly targeted therapies for kidney cancer.

To attain these goals, multiple approaches are utilized in the lab. Ongoing projects include: an RNAi screen of the Drosophila kinome, affinity chromatography studies to identify interacting proteins, genomic analyses of patient tumor samples, a synthetic lethal screen to identify tumor specific targets, molecular studies of drugs approved for use in patients with kidney cancer, as well as a variety of cellular and molecular biology projects. In addition, the laboratory works with several genetically engineered mouse models harboring mutations in various tumor suppressor genes including Vhl, Tsc1, Tsc2 as well as REDD1.

The laboratory offers an extraordinarily rich environment that encompasses both basic and translational research for highly motivated individuals interested in Cancer Biology.

For more information see: http://www4.utsouthwestern.edu/brugarolaslab/

Position requirements: candidates should hold an MD/PhD or PhD degree and be interested in a career in Academia.  

Interested individuals should send the following information:

1. A statement of interest explaining the reasons why the candidate is interested in the position and how the position might further the candidate’s career goals.
2. An updated CV.
3. Names and contact information for 3 professional references.

James Brugarolas, M.D., Ph.D.
Assistant Professor
c/o Bradley Hicks
Sr. Administrative Assistant
5323 Harry Hines Blvd.
Dallas, Tx 75390-9133
Bradley.Hicks@utsouthwestern.edu

UT Southwestern Medical Center is an Equal Opportunity, Affirmative Action Employer

Endocrinology 

There are no positions available at this time.  

Hematology Oncology, Internal Medicine

Molecular Mechanisms of Resistance to Hormonal Therapy of Prostate Cancer (89)

A postdoctoral position is available in the laboratory of Dr. Nima Sharifi in the Division of Hematology/Oncology.

This laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof.  Areas of interest in this laboratory include:

1. Specific mechanisms that lead to “ligand-independent” AR gain-of-function.
2. Metabolic and genetic changes required for androgen synthesis from adrenal precursors.
3. Animal models of advanced prostate cancer that are useful for translational and therapeutic studies.

The candidate should hold a doctoral degree with a background in transcriptional regulation, metabolism or cancer biology.  Candidates with an interest in the position should send their cv and contact information for 3 references to: 

Nima Sharifi, M.D.
Assistant Professor
Division of Hematology/Oncology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852
c/o Hem/Onc Research HemOncResearch@utsouthwestern.edu

Molecular Mechanisms of Tumor Suppression (74)

A post-doctoral position is available in the laboratory of Dr. Pier Paolo Scaglioni in the Department of Internal Medicine, Division of Hematology Oncology of the UT Southwestern Medical Center at Dallas, USA.

Areas of interest include:

1. Characterization of the tumor suppressive functions of the promyelocytic leukemia gene
2. Identification and characterization of non-small cell lung cancer initiating cells.
3. Elucidation of the mechanisms responsible for tumor addiction to oncogenic K-RAS. 

These research topics will be addressed with a combination of molecular/cellular biology techniques and mouse genetics taking advantage of lung cancer and leukemia mouse models.  For preliminary data please refer to our recent publications:  Cell. 2006. 126:269-83; Nature. 2006. 441:523-7; and Nat Cell Biol. 2004. 6:665-72.

Candidates should hold an M.D. and/or a Ph.D degree. Experience in the field of cellular/cancer biology is recommended.

Candidates should send their CV, career statement and contact information of three references to:

Pier Paolo Scaglioni, MD
HemOncResearch@utsouthwestern.edu

Molecular mechanisms and translational research in kidney cancer (19)

A postdoctoral position is available in the Brugarolas lab for entrepreneurial individuals pursuing a career in Academia who are interested in Cancer Biology.

The Brugarolas lab focuses on understanding kidney cancer. Specifically we are interested in:

1. Dissecting pathways involved in kidney cancer development, such as the mTOR pathway.
2. The discovery, using genomic platforms, of new pathways implicated in the pathogenesis of kidney cancer.
3. The development of novel paradigms for the evaluation of molecularly targeted therapies for kidney cancer.

To attain these goals, multiple approaches are utilized in the lab. Ongoing projects include: an RNAi screen of the Drosophila kinome, affinity chromatography studies to identify interacting proteins, genomic analyses of patient tumor samples, a synthetic lethal screen to identify tumor specific targets, molecular studies of drugs approved for use in patients with kidney cancer, as well as a variety of cellular and molecular biology projects. In addition, the laboratory works with several genetically engineered mouse models harboring mutations in various tumor suppressor genes including Vhl, Tsc1, Tsc2 as well as REDD1.

The laboratory offers an extraordinarily rich environment that encompasses both basic and translational research for highly motivated individuals interested in Cancer Biology.

For more information see: http://www4.utsouthwestern.edu/brugarolaslab/

Position requirements: candidates should hold an MD/PhD or PhD degree and be interested in a career in Academia.  

Interested individuals should send the following information:

1. A statement of interest explaining the reasons why the candidate is interested in the position and how the position might further the candidate’s career goals.
2. An updated CV.
3. Names and contact information for 3 professional references.

James Brugarolas, M.D., Ph.D.
Assistant Professor
c/o Bradley Hicks
Sr. Administrative Assistant
5323 Harry Hines Blvd.
Dallas, Tx 75390-9133
Bradley.Hicks@utsouthwestern.edu

UT Southwestern is an equal opportunity/affirmative action employer.

Hypertension, Department of Internal Medicine 

There are no positions available at this time. 

Department of Immunology

Protein/Antibody Engineering for the Therapy of Autoimmunity (85)

Postdoctoral positions are available in the laboratory of Prof. E. Sally Ward at UT Southwestern Medical Center at Dallas.  Projects will include the use of state-of-the-art approaches to generate novel antibody-based therapeutics for autoimmunity and cancer. The work will involve the engineering of antibody-Fc receptor interactions and the use of new transgenic mouse models. These studies are of considerable relevance to the rapidly expanding use of antibodies as diagnostics and therapeutics in the biopharma industry. The projects are supported by institutions such as the National Institutes of Health, the National Multiple Sclerosis Society and the biopharma industry.

In collaboration with Prof. R.J. Ober, the laboratory provides a unique inter- and multi-disciplinary environment. Students have the opportunity to work on challenging technological problems in the framework of a laboratory that is devoted to the study of questions of fundamental biological relevance.

For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab, or consult publications such as Proc. Natl. Acad. Sci. USA, in press, 2009; Proc. Natl. Acad. Sci. USA, 103, 18709-18714, 2006; Nature Biotechnol., 23, 1283-1288, 2005; J. Mol. Biol., 345, 1071-1081, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; Nature Biotechnol., 15, 637-640, 1997; Nature, 341, 544-546, 1989.

Highly motivated applicants with a Ph.D. in any biological area, biotechnology or chemistry will be considered, but preference will be given to those with relevant research experience.

For inquiries please send materials (full resume, statement of interest, transcripts and names/contact information for three references) to wardlab@utsouthwestern.edu.

Fluorescence Microscopy of Antibodies and Fc receptors (86)

Postdoctoral positions are available in the laboratory of Prof. E. Sally Ward and Prof. Raimund J. Ober at UT Southwestern Medical Center at Dallas. Projects will involve the development and/or implementation of state-of-the-art methods in fluorescence imaging to study the intracellular trafficking of antibodies and the Fc receptor, FcRn. Imaging methods will include the use of multifocal plane microscopy and superresolution approaches for single molecules/quantum dots to build up a three dimensional, dynamic understanding of intracellular processes. These studies have direct relevance to the rapidly expanding use of antibodies in the biopharma industry as therapeutics in autoimmunity, infectious diseases and cancer.

For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab, or publications such as Optics Express, 17, 6881-6898; Biophys J., 95, 6025-6043, 2008; Proc. Natl. Acad. Sci. USA, 104, 5889-5894, 2007; Proc. Natl. Acad. Sci. USA, 103, 4457-4462, 2006; Nature Biotechnol., 23, 1283-1288, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; IEEE Transactions Nanobioscience, 3, 237-242, 2004; J. Immunol., 172, 2021-2029, 2004; Biophys. J., 86, 1185-1200, 2004.

Highly motivated individuals with a background in any biological area, (bio)engineering, biotechnology, chemistry, physics, mathematics or any other physical science will be considered. Direct experience is not necessary. These positions provide the opportunity for the successful candidate to gain experience in advanced microscopic techniques applied to important problems in biotechnology.

For inquiries please send materials (full resume, statement of interest, transcripts, three references) to wardlab@utsouthwestern.edu.

Adhesion Receptor Function in T Cell Regulation and Autoimmunity (83)

A post-doctoral position studying the role of lymphocyte adhesion molecules in the regulation of inflammatory bowel disease is available in the laboratory of Dr. Mark H. Siegelman, Departments of Pathology and Immunology. Candidates should have a recent Ph.D. or M.D. with a strong research background in cellular immunology, immune regulation, and autoimmune disease. Specific experience in murine models of autoimmunity or human autoimmune disease is highly desirable, as is experience with multi-color flow cytometry, lymphocyte function analyses, and molecular biology. Ongoing studies will use both cellular and molecular methods to characterize adhesion molecules as markers of regulatory T cells and their application to the control of human autoimmune disease and mouse models thereof (Blood 107: 619-627).

Qualified candidates should send a current Curriculum Vitae describing their research background along with three (3) letters of reference to:

Mark Siegelman, M.D., Ph.D.
Department of Pathology MC9072
UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd.
Dallas, TX  75390-9072
mark.siegelman@utsouthwestern.edu 

Postdoctoral Research Scholar in Autoimmunity (66)

We are seeking a highly motivated scientist with expertise in genetic engineering to join the Mohan Lab at UT Southwestern Medical Center in Dallas, TX.  Applicants should have a PhD in a biomedical field.  Recent PhD graduates are encouraged to apply.  A summary of research can be found at http://www4.utsouthwestern.edu/mohanlab/ or http://www.utsouthwestern.edu/utsw/cda/dept20539/files/131854.html

Please email a resume and 3 letters of recommendation to Dr. Mohan at chandra.mohan@utsouthwestern.edu. 

UT Southwestern is an Equal Opportunity, Affirmative Action Employer. 

Division of Infectious Diseases, Department of Internal Medicine

Infectious Diseases Training Grant (81)

We are targeting recruitment to M.D., M.D./Ph.D. or Ph.D. postdoctoral fellows who desire laboratory research training related to Infectious Diseases under an Infectious Diseases Training Program-based Preceptor.  Trainees selected based on scientific training & potential for independent investigation.  US Citizens & Permanent Residents only.  Interested individuals are encouraged to identify a mentor from the following list of preceptors about participation in program at address below.  Additional information on preceptors can be found by visiting www.utsouthwestern.edu.

Interested individuals should submit a short statement of research interests, a current curriculum vitae and a statement of training plan objectives to the Program Director, Beth Levine, M.D., at the address below:

c/o Ms. Deborah Solomon
Deborah.Solomon@UTSouthwestern.edu
UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd.
Dallas, TX  75390-9113