Advanced Imaging Research Center
There are no available positions at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer
Department of Biochemistry
Biochemical Mechanisms of RNA Interference (RNAi) (107)
A Postdoctoral position is available in the laboratory of Dr. Qinghua Liu at the Department of Biochemistry, UT Southwestern Medical Center at Dallas, USA.
Candidates require a Ph.D with a strong background in the field of Biochemistry and Molecular Biology. The primary focus of research includes: 1) Biochemical studies of the Drosophila and human RNA-induced silencing complex (RISC), the catalytic engine of RNAi. 2) Regulatory mechanisms of miRNA biogenesis and effector functions. These research topics will be addressed using a classic biochemical fractionation and reconstitution approach. For preliminary data, please refer to our recent publications:
Science (2009) 325:750-3; Cell (2009) 139: 112-22 and to our website:
http://www.utsouthwestern.edu/findfac/research/0,2357,50723,00.html.
Please email you CV and contact information for three references to:
Qinghua Liu, Ph.D.
Assistant Professor
Department of Biochemistry
email: qinghua.liu@utsouthwestern.edu
UT Southwestern is an Equal Opportunity, Affirmative Action Employer
Harold C. Simmons Comprehensive Cancer Center 
Transcriptional Regulation (109)
Research Area: Transcription, Chromatin, Gene Regulation, Posttranslational Modification, and Molecular Virology
Description of project: A postdoctoral position is available to study mechanisms of chromatin-dependent transcription and posttranslational modification of transcription factors, cofactors and the general transcription machinery. In vitro-reconstituted chromatin transcription systems are frequently used in the lab to identify factors and pathways leading to gene activation and repression. Current focuses include functional interplays between AP-1, C/EBP, YY1, p53, and HPV-encoded E2 and E6 proteins. Several cellular chromatin adaptors, including Brd4, are also studied to define their roles in mediating cellular and viral gene expression.
Applicants with a Ph.D. degree and a strong background in protein biochemistry, molecular biology and virology are encouraged to apply.
Please forward your CV and names of three referees to:
Dr. Cheng-Ming Chiang
Simmons Comprehensive Cancer Center
UT Southwestern Medical Center
5323 Harry Hines Blvd., ND2.210H
Dallas, Texas 75390-8807
Phone: (214) 645-6128
Fax: (214) 645-6347
E-mail: Cheng-Ming.Chiang@UTSouthwestern.edu
Website: http://www.utsouthwestern.edu/findfac/research/0,2357,95126,00.html
Molecular Mechanisms of Tumor Suppression (103)
A Postdoctoral Scholar position is available in the laboratory of Dr. Pier Paolo Scaglioni in the Department of Internal Medicine, Division of Hematology Oncology, UT Southwestern Medical Center at Dallas, USA. Ph.D. and/or M.D. with a strong background in the field of cellular/cancer biology is required. Areas of interest include the characterization of the tumor suppressive functions of the promyelocytic leukemia gene in hematopoietic malignancies and in solid tumors, and the study of the role of oncogenic K-RAS in initiating and maintaining non-small cell lung cancer. These research topics will be addressed with a combination of molecular/cellular biology techniques and mouse genetics taking advantage of lung cancer and leukemia mouse models. For preliminary data please refer to our recent publications: Cell. 2006. 126:269-83; Nature. 2006. 441:523-7; and Nat Cell Biol. 2004. 6:665-72 and to our lab website: http://www4.utsouthwestern.edu/scaglionilab/default.asp.
Candidates should send their CV, career statement, and contact information for three references to:
Pier Paolo Scaglioni, M.D.
email: HemOncResearch@utsouthwestern.edu
Molecular Mechanisms of Resistance to Hormonal Therapy of Prostate Cancer (89)
A postdoctoral position is available in the laboratory of Dr. Nima Sharifi in the Division of Hematology/Oncology.
This laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof. Areas of interest in this laboratory include:
- Specific mechanisms that lead to “ligand-independent” AR gain-of-function.
- Metabolic and genetic changes required for androgen synthesis from adrenal precursors.
- Animal models of advanced prostate cancer that are useful for translational and therapeutic studies.
The candidate should hold a doctoral degree with a background in transcriptional regulation, metabolism or cancer biology. Candidates with an interest in the position should send their cv and contact information for 3 references to:
Nima Sharifi, M.D.
Assistant Professor
Division of Hematology/Oncology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852
c/o Hem/Onc Research HemOncResearch@utsouthwestern.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer
Cardiology, Department of Internal Medicine
There are no available positions at this time.
UT Southwestern is an equal opportunity/affirmative action employer.
Cell Biology
Mechanisms of Signal Transduction within Cilia and Flagella (110)
Job Description:
A postdoctoral position is available to study the cell and molecular mechanisms of signal transduction within the flagella of the unicellular green alga, Chlamydomonas. Our laboratory has shown that intraflagellar transport is essential for coupling receptor binding on the flagellar membrane to activation of a signal transduction pathway within the flagella. We are taking advantage of our ability to isolate biochemical quantities of flagella from Chlamydomonas, the availability of Chlamydomonas bearing mutations in specific signaling pathways, and the ease of working with this simple biflagellated eukaryote to discover fundamental properties of cilium-generated signaling.
Job Requirements:
Candidates are expected to have a Ph.D. with a strong background in cell and molecular biology.
Key word: postdoc; postdoctoral fellow
Job Details:
Discovery Science, Primary Research
To Apply:
Please submit CV and three letters of recommendation to:
William J. Snell, Ph.D.
Department of Cell Biology,
University of Texas Southwestern Medical School Rm. K2-226
5323 Harry Hines Blvd.
Dallas, TX 75390-9039
Email:cilia@utsouthwestern.edu
The University of Texas Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. Women and minority candidates are encouraged to apply.
Cellular And Molecular Mechanisms Of Cilium-Based Signaling And Intraflagellar Transport (105)
A postdoctoral position is available to study the cell and molecular biology of cilium-generated signaling and intraflagellar transport during fertilization in the green alga Chlamydomonas. The anticipated start date is October 1, 2009.
The candidate is expected to have a Ph.D. degree with a strong background in molecular and cell biology and biochemistry. Applicants should submit curriculum vitae with names and contact information of three references to:
Dr. William J. Snell
Department of Cell Biology
UT Southwestern Medical Center
5323 Harry Hines Blvd
Dallas, Texas 75390-9039
Email: william.snell@utsouthwestern.edu
Cell Signaling and Cancer (98)
Two NIH-funded postdoctoral positions are available immediately for highly motivated individuals to study the cellular and molecular mechanisms underlying cytokine receptor signaling in hematopoietic stem and progenitor cells, and in hematological malignancies. For more information see: http://www4.utsouthwestern.edu/huanglab/contact.htm
A recent Ph.D. degree with strong background in molecular biology, biochemistry, and tissue culture is required. Prior experience with mouse models is desirable. Please send (via email if possible) curriculum vitae and names and contact information of three (3) references to:
Lily Huang, Ph.D.,
Assistant Professor
Department of Cell Biology
University of Texas Southwestern Medical Center at Dallas
5323 Harry Hines Boulevard
Dallas, TX 75390-9039
Lily.Huang@utsouthwestern.edu
UT Southwestern Medical Center is an Equal Opportunity, Affirmative Action Employer
Center for Human Nutrition
There are no positions available at this time.
Clinical Sciences
There are no positions available at this time.
Department of Dermatology
There are no positions available at this time.
Developmental Biology Department
There are no positions available at this time.
UT Southwestern Medical Center is an Equal Opportunity, Affirmative Action Employer
Digestive and Liver Diseases, Internal Medicine
NF-kB regulation, ubiquitination and inflammatory responses in mouse models (93)
The Department of Internal Medicine, Division of Digestive and Liver Diseases, has a post-doctoral position available to study NF-kB regulation, ubiquitination and inflammatory responses in mouse models. Laboratory is focused on the ubiquitination of NF-kB/RelA and its role in inflammatory responses (EMBO Journal, 26: 459-467, 2007; Genes & Development, 23: 849-861, 2009). Additional information about our research area can be found at http://www.utsouthwestern.edu/utsw/cda/dept24482/files/536923.html. Candidates with PhD or equivalent degree and a demonstrated track record in molecular biology, and mouse models of inflammation are preferred.
Send complete curriculum vitae and three references to:
Dr. Ezra Burstein
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, Texas 75230-9151
ezra.burstein@utsouthwestern.edu
UT Southwestern Medical Center is an Equal Opportunity, Affirmative Action Employer
Endocrinology
There are no positions available at this time.
Hematology Oncology, Internal Medicine
Molecular Mechanisms of Tumor Suppression (103)
A Postdoctoral Scholar position is available in the laboratory of Dr. Pier Paolo Scaglioni in the Department of Internal Medicine, Division of Hematology Oncology, UT Southwestern Medical Center at Dallas, USA. Ph.D. and/or M.D. with a strong background in the field of cellular/cancer biology is required. Areas of interest include the characterization of the tumor suppressive functions of the promyelocytic leukemia gene in hematopoietic malignancies and in solid tumors, and the study of the role of oncogenic K-RAS in initiating and maintaining non-small cell lung cancer. These research topics will be addressed with a combination of molecular/cellular biology techniques and mouse genetics taking advantage of lung cancer and leukemia mouse models. For preliminary data please refer to our recent publications: Cell. 2006. 126:269-83; Nature. 2006. 441:523-7; and Nat Cell Biol. 2004. 6:665-72 and to our lab website: http://www4.utsouthwestern.edu/scaglionilab/default.asp.
Candidates should send their CV, career statement, and contact information for three references to:
Pier Paolo Scaglioni, M.D.
email: HemOncResearch@utsouthwestern.edu
Molecular Mechanisms of Resistance to Hormonal Therapy of Prostate Cancer (89)
A postdoctoral position is available in the laboratory of Dr. Nima Sharifi in the Division of Hematology/Oncology.
This laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof. Areas of interest in this laboratory include:
- Specific mechanisms that lead to “ligand-independent” AR gain-of-function.
- Metabolic and genetic changes required for androgen synthesis from adrenal precursors.
- Animal models of advanced prostate cancer that are useful for translational and therapeutic studies.
The candidate should hold a doctoral degree with a background in transcriptional regulation, metabolism or cancer biology. Candidates with an interest in the position should send their cv and contact information for 3 references to:
Nima Sharifi, M.D.
Assistant Professor
Division of Hematology/Oncology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852
c/o Hem/Onc Research HemOncResearch@utsouthwestern.edu
UT Southwestern is an equal opportunity/affirmative action employer.
Hypertension, Department of Internal Medicine
There are no positions available at this time.
Department of Immunology
Regulation of T-Cell Receptor Signaling Pathways (91)
We have an immediate position open for a postdoctoral trainee with prior experience in molecular biology, signal transduction, and/or mouse husbandry. This person must hold a Ph.D. from a recognized Institute. There are two research projects available. The first is to characterize T cell receptor (TCR) and innate receptor signaling pathways in mice lacking a protein tyrosine phosphatase termed PTPN4. This phosphatase was previously shown to dephosphorylate signaling domains in the immune cell receptors termed the immune tyrosine-based activation motif. The second project involves the characterization of a novel, phospholipid-binding motif in the CD3 epsilon subunit of the TCR complex.
Dr. Nicolai van Oers
Associate Professor
Department of Immunology
email:nicolai.vanoers@utsouthwestern.edu
214-648-1236
Adhesion Receptor Function in T Cell Regulation and Transplantation (84)
A postdoctoral position studying the role of lymphocyte adhesion molecules in the regulation of immune-mediated organ transplant rejection is available in the laboratory of Dr. Mark H. Siegelman, Departments of Pathology and Immunology. Candidates should have a recent Ph.D. or M.D. with a strong research background in cellular immunology and immune regulation. Specific experience in murine models of immunity or human autoimmune disease is highly desirable, as is experience with multi-color flow cytometry, lymphocyte function analyses, and molecular biology. Ongoing studies will use both cellular and molecular methods to characterize adhesion molecules as markers of regulatory T cells and their application to the control of organ transplant rejection and mouse models thereof (Blood 107: 619-627).
Qualified candidates should send a current Curriculum Vitae describing their research background along with three (3) letters of reference to:
Mark Siegelman, M.D., Ph.D.
Department of Pathology MC9072
UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd.
Dallas, TX 75390-9072
mark.siegelman@utsouthwestern.edu
Protein/Antibody Engineering for the Therapy of Autoimmunity (85)
Postdoctoral positions are available in the laboratory of Prof. E. Sally Ward at UT Southwestern Medical Center at Dallas. Projects will include the use of state-of-the-art approaches to generate novel antibody-based therapeutics for autoimmunity and cancer. The work will involve the engineering of antibody-Fc receptor interactions and the use of new transgenic mouse models. These studies are of considerable relevance to the rapidly expanding use of antibodies as diagnostics and therapeutics in the biopharma industry. The projects are supported by institutions such as the National Institutes of Health, the National Multiple Sclerosis Society and the biopharma industry.
In collaboration with Prof. R.J. Ober, the laboratory provides a unique inter- and multi-disciplinary environment. Students have the opportunity to work on challenging technological problems in the framework of a laboratory that is devoted to the study of questions of fundamental biological relevance.
For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab, or consult publications such as Proc. Natl. Acad. Sci. USA, in press, 2009; Proc. Natl. Acad. Sci. USA, 103, 18709-18714, 2006; Nature Biotechnol., 23, 1283-1288, 2005; J. Mol. Biol., 345, 1071-1081, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; Nature Biotechnol., 15, 637-640, 1997; Nature, 341, 544-546, 1989.
Highly motivated applicants with a Ph.D. in any biological area, biotechnology or chemistry will be considered, but preference will be given to those with relevant research experience.
For inquiries please send materials (full resume, statement of interest, transcripts and names/contact information for three references) to wardlab@utsouthwestern.edu.
Fluorescence Microscopy of Antibodies and Fc receptors (86)
Postdoctoral positions are available in the laboratory of Prof. E. Sally Ward and Prof. Raimund J. Ober at UT Southwestern Medical Center at Dallas. Projects will involve the development and/or implementation of state-of-the-art methods in fluorescence imaging to study the intracellular trafficking of antibodies and the Fc receptor, FcRn. Imaging methods will include the use of multifocal plane microscopy and superresolution approaches for single molecules/quantum dots to build up a three dimensional, dynamic understanding of intracellular processes. These studies have direct relevance to the rapidly expanding use of antibodies in the biopharma industry as therapeutics in autoimmunity, infectious diseases and cancer.
For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab, or publications such as Optics Express, 17, 6881-6898; Biophys J., 95, 6025-6043, 2008; Proc. Natl. Acad. Sci. USA, 104, 5889-5894, 2007; Proc. Natl. Acad. Sci. USA, 103, 4457-4462, 2006; Nature Biotechnol., 23, 1283-1288, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; IEEE Transactions Nanobioscience, 3, 237-242, 2004; J. Immunol., 172, 2021-2029, 2004; Biophys. J., 86, 1185-1200, 2004.
Highly motivated individuals with a background in any biological area, (bio)engineering, biotechnology, chemistry, physics, mathematics or any other physical science will be considered. Direct experience is not necessary. These positions provide the opportunity for the successful candidate to gain experience in advanced microscopic techniques applied to important problems in biotechnology.
For inquiries please send materials (full resume, statement of interest, transcripts, three references) to wardlab@utsouthwestern.edu.
Adhesion Receptor Function in T Cell Regulation and Autoimmunity (83)
A post-doctoral position studying the role of lymphocyte adhesion molecules in the regulation of inflammatory bowel disease is available in the laboratory of Dr. Mark H. Siegelman, Departments of Pathology and Immunology. Candidates should have a recent Ph.D. or M.D. with a strong research background in cellular immunology, immune regulation, and autoimmune disease. Specific experience in murine models of autoimmunity or human autoimmune disease is highly desirable, as is experience with multi-color flow cytometry, lymphocyte function analyses, and molecular biology. Ongoing studies will use both cellular and molecular methods to characterize adhesion molecules as markers of regulatory T cells and their application to the control of human autoimmune disease and mouse models thereof (Blood 107: 619-627).
Qualified candidates should send a current Curriculum Vitae describing their research background along with three (3) letters of reference to:
Mark Siegelman, M.D., Ph.D.
Department of Pathology MC9072
UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd.
Dallas, TX 75390-9072
mark.siegelman@utsouthwestern.edu
UT Southwestern is an Equal Opportunity, Affirmative Action Employer.
Division of Infectious Diseases, Department of Internal Medicine
Autophagy Roles in Cell Death Regulation, Cancer Biology, and Infectious Diseases (104)
Postdoctoral Research Positions available to study the molecular mechanisms, regulation, and functions of autophagy, including its roles in cell death regulation, cancer biology, and infectious diseases. Ph.D. and/or M.D. required. Candidates should have a strong foundation in molecular biology, cell biology, and/or biochemistry.
Send curriculum vitae and three letters of reference to:
Beth Levine, M.D.
Howard Hughes Medical Institute
Department of Internal Medicine
University of Texas Southwestern Medical Center
Dallas, Texas, 75390-9113
E-mail: cindy.jozefiak@utsouthwestern.edu
Laboratory website: http://www4.utsouthwestern.edu/idlabs/Levine/Levine_intro.htm
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