Original Articles
1. Zigman JM, Westermark GT, LaMendola J, Boel E, Steiner DF. Human Golfα: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system. Endocrinology 1993;133:2508-2514.
2. Zigman JM, Westermark GT, LaMendola J, Steiner DF. Expression of cone transducin, Gzα and other G-protein α-subunit messenger ribonucleic acids in pancreatic islets. Endocrinology 1994;135:31-37.
3. Zigman JM, Cohen SE, Garber JR. Impact of thyroxine binding globulin on thyroid hormone economy during pregnancy. Thyroid 2003;13:1169-1175.
4. Zigman, JM, Garber JR. Increased TBG during pregnancy and increased hormonal requirements: Authors’ response. Thyroid 2004;14:480-481.
5. Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 2005;115:3564-3572.
6. Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 2006;494:528-548.
7. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua Jr. S, Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006;49:191-203.
8. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang C-Y, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006;51:239-249.
9. Clegg DJ, Brown LM, Zigman JM, Kemp CJ, Strader AD, Benoit SC, Woods SC, Mangiaracina M, Geary N. Estradiol-dependent decrease in the orexigenic potency of ghrelin in food intake. Diabetes 2007;56:1051-1058.
10. Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metabolism 2007; 5:383-393. PMCID: PMC1934926.
11. Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S, Birnbaum S, Yanagisawa M, Elmquist JK, Nestler EJ, Zigman JM. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci. 2008; 11:752-753. PMCID: PMC2765052.
12. Xu Y, Jones JE, Lee CE, Choi MJ, Anderson JG, Heisler L, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs Expressed by Pro-opiomelanocortin Neurons Regulate Energy Homeostasis. Neuron. 2008; 60:582-589. PMCID: PMC2631191.
13. Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, and Elmquist JK. Monitoring FoxO1 localization in chemically identified neurons. J Neurosci. 2008; 28:13640-13648. PMCID: PMC2615536.
14. Davies JS, Kotokorpi P, Eccles SR, Barnes SK, Tokarczuk PF, Allen SK, Whitworth HS, Guschina IA, Evans BA, Mode A, Zigman JM, Wells T. Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol. 2009; 23:914-924. PMCID: PMC2691683.
15. Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM. Characterization of a novel ghrelin cell reporter mouse. Reg Peptides. 2009; 55:91-98. PMCID: PMC2697121.
16. Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM. Co-localization of ghrelin O-acyltransferase (GOAT) and ghrelin in gastric mucosal cells. AJP Endo Metab. 2009; 297:E134-E141. PMCID: PMC2711663.
17. Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, Elsworth JD, Savitt JM, DiMarchi R, Tschoep M, Roth RH, Gao XB, Horvath TL. Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci. 2009;29:14057-65. PMCID: PMC2845822.
18. Perello M, Sakata I, Birnbaum S, Chuang J-C, Osborne-Lawrence S, Rovinsky SA, Woloszyn J, Yanagisawa M, Lutter M*, Zigman JM*. Ghrelin increases the rewarding value of high fat diet in an orexin-dependent manner. Biol Psychiatry 2010; 67:880-886. PMCID: PMC2854245.
19. Chuang J-C, Krishnan V, Yu HG, Wilkinson MB, Zigman JM, Elmquist JK, Nestler EJ, Lutter M. β3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress. Biol Psychiatry 2010;67:1075-1082. PMCID: PMC2868111.
20. Chuang J-C, Cui H, Mason BL, Mahgoub M, Bookout AL, Yu HG, Perello M, Elmquist JK, Repa JJ, Zigman JM, Lutter M. Chronic social defeat stress disrupts regulation of lipid synthesis. J Lipid Res. 2010;51:1344-1353. PMCID: PMC3035497.
21. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang J-C, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010; 11:286-297. PMCID: PMC2854520.
22. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010; 12:88-95. PMCID: PMC2919367.
23. Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CP, Clegg DJ. Distribution and Neurochemical Characterization of PKC-theta and -delta in the Rodent Hypothalamus. Neuroscience. 2010 ; 170(4):1065-79.
24. Zhao TJ*, Sakata I*, Li RL, Liang G, Richardson JA, Brown MS, Goldstein JL, Zigman JM. Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc Natl Acad Sci U S A. 2010; 107(36):15868-73. PMCID: PMC2936616.
25. Xu Y, Berglund ED, Sohn J-W, Holland WL, Chuang J-C, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010;13:1457-1459. PMCID: PMC3059249.
26. Donato Jr J, Cravo RM, Frazão R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee CE, Richardson JA, Friedman J, Chua Jr. S, Coppari R, Zigman JM, Elmquist JK, Elias CF. Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. JCI. 2011;121:355-368. PMCID: PMC3007164.
27. Cravo RM, Margatho LO, Osborne-Lawrence S, Donato Jr J, Atkin S, Bookout AL, Rovinsky S, Frazão R, Lee CE, Gautron L, Zigman JM* and Elias CF*. Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience. 2011;173:37-56. (* co-submitting senior authors) PMCID: PMC3026459.
28. Vialou V, Cui H, Perello M, Mahgoub M, Yu HM, Rush AJ, Pranav H, Jung S, Yangisawa M, Ghose S, Zigman JM, Tamminga C, Elmquist JK, Nestler EJ, Lutter M. A role for delta FosB in calorie restriction-induced metabolic changes. Biol Psychiatry. 2011;70:204-207. PMCID: PMC3125466
29. Chuang J-C*, Perello M*, Sakata I, Osborne-Lawrence S, Savitt JM, Lutter M, Zigman JM. Ghrelin mediates stress-induced food-reward behavior in mice. J Clin Invest. 2011; 121:2684-2692.
30. Gautron L, Sakata I, Udit S, Zigman JM, Wood JN, Elmquist JK. Genetic tracing of Nav1.8-expressing vagal afferents in the mouse. J Comp Neurol. 2011;519:3085-3101.
31. Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC. Nat Neurosci. 2011; 14:911-918.
32. Perello M*, Scott MM*, Sakata I, Lee CE, Chuang J-C, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM. Functional implications of limited leptin receptor and ghrelin receptor co-expression in the brain. J Comp Neurol. 2011. Jun 14. In Press.
33. Chuang J-C, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM. Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells. Mol Endocrinol. 2011;25:1600-1611.
Reviews, Chapters, and Editorials
1. Zigman J. Obesity. In: Lucas BP, Halasyamani LK, editors. Pocket Primary Care. Philadelphia: Lippincott, Williams, & Wilkins; 2001. p. 15.
2. Zigman J. Muscle cramps. In: Lucas BP, Halasyamani LK, editors. Pocket Primary Care. Philadelphia: Lippincott, Williams, & Wilkins; 2001. p. 191-192.
3. Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Zigman JM, Cone RD, Elmquist JK. Central serotonin and melanocortin pathways regulating energy homeostasis. Ann NY Acad Sci 2003;994:169-174.
4. Zigman JM, Elmquist JK. Minireview: From anorexia to obesity -- the yin and yang of body weight control. Endocrinology 2003;144:3749-3756.
5. Elmquist J, Zigman J, Lutter M. Molecular determinants of energy homeostasis. Am J Psychiatry 2006;163:1137.
6. Zigman JM, Elmquist JK. In search of an effective obesity treatment: A shot in the dark or a shot in the arm? PNAS 2006;103:12961-12962.
7. Nogueiras R, Tschöp MH, Zigman JM. CNS regulation of energy metabolism: ghrelin versus leptin. Ann NY Acad Sci. 2008;1126:14-19. PMCID: PMC2814160
8. Lee S, Zigman JM. New molecular targets for the treatment of obesity. www.endotext.org website, version of 4/24/08, ed. M. Tschoep, published by Mdtext.com, Inc., S. Dartmouth, MA.
9. Chuang J-C, Zigman JM. Ghrelin’s Roles in Stress, Mood and Anxiety. Int J Peptides. 2010;2010. pii: 460549. Epub 2010 Feb 14. PMCID: PMC2915752
