Publications (Osamu Nakagawa):
60. King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O. Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochem. Biophys. Res. Commun. 345(1):446-452, 2006.
59. Murakami M, Tominaga J, Makita R, Uchijima Y, Kurihara Y, Nakagawa O, Asano T, Kurihara Y. Transcriptional activity of Pax3 is co-activated by TAZ. Biochem. Biophys. Res. Commun. 339(2):533-539, 2006.
58. Murakami M, Nakagawa M, Olson EN, Nakagawa O. A WW domain protein TAZ is a critical co-activator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Nat. Acad. Sci. USA 102(50): 18034-18039, 2005.
57. Nakagawa O, Arnold M, Nakagawa M, Hamada H, Shelton JM, Kusano H, Harris TM, Childs G, Campbell KP, Richardson JA, Nishino I, Olson EN. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 19(17): 2066-2077, 2005.
56. Phan D, Rasmussen TL, Nakagawa O, McAnally J, Gottlieb PD, Tucker PW, Richardson JA, Bassel-Duby R, Olson EN. Bop, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the anterior heart field. Development 132(11): 2669-2678, 2005.
55. Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JA, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J. Biol. Chem. 279(52): 54937-54943, 2004.
54. Murakami M, Kataoka K, Tominaga J, Nakagawa O, Kurihara H. Differential cooperation between dHAND and three different E-proteins. Biochem. Biophys. Res. Commun. 323(1): 168-174, 2004.
53. Murakami M, Kataoka K, Fukuhara S, Nakagawa O, Kurihara H. Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity. Eur J Biochem. 271(16): 3330-3339, 2004.
52. Gottlieb PD, Pierce SA, Sims RJ III, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nature Genet. 31(1): 25-32, 2002.
51. Nakanishi K, Tajima F, Itoh H, Nakata Y, Osada H, Hama N, Nakagawa O, Nakao K, Kawai T, Takishima K, Aurues T, Ikeda T. Changes in atrial natriuretic peptide and brain natriuretic peptide associated with hypobaric hypoxia-induced pulmonary hypertension in rats. Virchows Arch. 439(6): 808-817, 2001.
50. Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D. The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricular formation. Dev. Biol. 239(2): 190-203, 2001.
49. Harada E, Yoshimura M, Yasue H, Nakagawa O, Nakagawa M, Harada M, Mizuno Y, Nakayama M, Shimasaki Y, Ito T, Nakamura S, Kuwahara K, Saito Y, Nakao K, Ogawa H. Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes. Circulation 104(2): 137-139, 2001.
48. Liu Z-P*, Nakagawa O*, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN (* equal contribution). CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev. Biol. 234(2): 497-509, 2001.
47. Nakagawa M, Tanaka I, Mukoyama M, Suga S, Ogawa Y, Tamura N, Ishibashi R, Goto M, Nakagawa O, Sugawara A, Nakao K. Monoclonal antibody against brain natriuretic peptide (BNP) and characterization of BNP-transgenic mice. J. Hypertens. 19(3): 475-483, 2001.
46. Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN. Members of the HRT family of bHLH proteins act as transcriptional repressors downstream of Notch signaling. Proc. Nat. Acad. Sci. USA 97(25): 13655-13660, 2000.
45. Ikeda K, Tojo K, Tokudome G, Akashi T, Hosoya T, Harada M, Nakagawa O, Nakao K. Possible involvement of endothelin-1 in cardioprotective effects of benidipine. Hypertens. Res. 23(5): 491-496, 2000.
44. Ogawa E, Saito Y, Harada M, Kamitani S, Kuwahara K, Miyamoto Y, Ishikawa M, Hamanaka I, Kajiyama N, Takahashi N, Nakagawa O, Masuda I, Kishimoto I, Nakao K. Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes. J. Mol. Cell. Cardiol. 32(5): 765-776, 2000.
43. Nakagawa O, Nakagawa M, Richardson JA, Olson EN, Srivastava D. HRT1, HRT2, HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments. Dev. Biol. 216(1): 72-84, 1999.
42. Nakanishi K, Tajima F, Itoh H, Nakata Y, Hama N, Nakagawa O, Nakao K, Kawai T, Torikata C, Suga T, Takishima K, Aurues T, Ikeda T. Expression of C-type natriuretic peptide during development of rat lung. Am. J. Physiol. 277(5 Pt 1): L996-L1002, 1999.
41. Harada E, Nakagawa O, Yoshimura M, Harada M, Nakagawa M, Mizuno Y, Shimasaki Y, Nakayama M, Yasue H, Kuwahara K, Saito Y, Nakao K. Effect of interleukin-1? on cardiac hypertrophy and production of natriuretic peptides in rat cardiocyte culture. J. Mol. Cell. Cardiol. 31(11): 1997-2006, 1999.
40. Ishikawa M, Saito Y, Miyamoto Y, Harada M, Kuwahara K, Ogawa E, Nakagawa O, Hamanaka I, Kajiyama N, Takahashi N, Masuda I, Hashimoto T, Sakai O, Hosoya T, Nakao K. A heart-specific increase in cardiotrophin-1 gene expression precedes the establishment of ventricular hypertrophy in genetically hypertensive rats. J. Hypertens. 17(6): 807-816, 1999.
39. Kuwahara K, Saito Y, Harada M, Ishikawa M, Ogawa E, Miyamoto Y, Hamanaka I, Kamitani S, Kajiyama N, Takahashi N, Nakagawa O, Masuda I, Nakao K. Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro. Circulation 100(10): 1116-1124, 1999.
38. Kuwahara K, Saito Y, Nakagawa O, Kishimoto I, Harada M, Ogawa E, Miyamoto Y, Hamanaka I, Kajiyama N, Takahashi N, Izumi T, Kawakami R, Tamura N, Ogawa Y, Nakao K. The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes. -Possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy. FEBS Lett. 452(3): 314-318, 1999.
37. Ikeda K, Tojo K, Sato S, Ebisawa T, Tokudome G, Hosoya T, Harada M, Nakagawa O, Nakao K. Urocortin, a newly identified corticotropin-releasing factor-related mammalian peptide, stimulates atrial natriuretic peptide and brain natriuretic peptide secretions from neonatal rat cardiomyocytes. Biochem. Biophys. Res. Commun. 250(2): 298-304, 1998.
36. Kugiyama K, Doi H, Motoyama T, Soejima H, Misumi K, Kawano H, Nakagawa O, Yoshimura M, Ogawa H, Matsumura T, Sugiyama S, Nakano T, Nakajima K, Yasue H. Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation 97(25): 2519-2526, 1998.
35. Harada M, Saito Y, Kuwahara K, Ogawa E, Ishikawa M, Nakagawa O, Miyamoto Y, Kamitani S, Hamanaka I, Kajiyama N, Takahashi N, Masuda I, Itoh H, Nakao K. Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture. J. Cardiovasc. Pharmacol. 31(Suppl 1): S357-S359, 1998.
34. Kuwahara K, Saito Y, Ogawa Y, Tamura N, Ishikawa M, Harada M, Ogawa E, Miyamoto Y, Hamanaka I, Kamitani S, Kajiyama N, Takahashi N, Nakagawa O, Masuda I, Nakao K. Endothelin-1 and cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms. J. Cardiovasc. Pharmacol. 31(Suppl 1): S354-S356, 1998.
33. Harada M, Itoh H, Nakagawa O, Ogawa Y, Miyamoto Y, Kuwahara K, Ogawa E, Igaki T, Yamashita J, Masuda I, Yoshimasa T, Tanaka I, Saito Y, Nakao K. Significance of ventricular myocytes andnonmyocytes interation during cardiocytes hypertrophy. -Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes.- Circulation 96(10): 3737-3744, 1997.
32. Doi K, Itoh H, Nakagawa O, Igaki T, Yamashita J, Chun T-H, Inoue M, Masatsugu K, Nakao K. Expression of natriuretic peptide system during embryonic stem cell vasculogenesis. Heart Vessels Suppl 12: 18-22, 1997.
31. Harada M, Saito Y, Nakagawa O, Miyamoto Y, Ishikawa M, Kuwahara K, Ogawa E, Nakayama M, Kamitani S, Hamanaka I, Kajiyama N, Masuda I, Itoh H, Tanaka I, Nakao K. Role of cardiac nonmyocytes in cyclic mechanical stretch-induced myocyte hypertrophy. Heart Vessels Suppl 12: 198-200, 1997.
30. Sasaki Y, Takahashi T, Tanaka I, Nakamura K, Okuno Y, Nakagawa O, Narumiya S, Nakao K. Expression of prostacyclin receptor in human megakaryocytes. Blood 90(3): 1039-1046, 1997.
29. Nakao K, Saito Y, Itoh H, Ogawa Y, Nakagawa O, Harada M, Masuda I, Yoshimasa T. Roles of natriuretic peptides in heart failure. J. Card. Fail. 2(Suppl 4): S129-133, 1996.
28. Tamura N, Itoh H, Ogawa Y, Nakagawa O, Harada M, Chun T-H, Suga S, Yoshimasa T, Nakao K. cDNA cloning and gene expression of human type I alpha cGMP-dependent protein kinase. Hypertension 27(3 pt 2): 552-557, 1996.
27. Tojo K, Sato S, Tokudome G, Ohta M, Kawaguchi Y, Sakai O, Nakagawa O, Nakao K. Stimulation by corticotropin-releasing factor of atrial natriuretic peptide and brain natriuretic peptide secretions from cultured neonatal rat cardiomyocytes. Biochem. Biophys. Res. Commun. 225(2): 340-346, 1996.
26. Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K, Narumiya S.
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS lett. 392(2): 189-193, 1996.
25. Mori K, Tanaka I, Kotani M, Miyaoka F, Sando T, Muro S, Sasaki Y, Nakagawa O, Ogawa Y, Usui T, Ozaki S, Ichikawa A, Narumiya S, Nakao K. Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester. J. Mol. Med. 74(6): 333-336, 1996.
24. Komatsu Y, Itoh H, Suga S, Igaki T, Ogawa Y, Kishimoto I, Nakagawa O, Yoshimasa T, Nakao K. Regulation of secretion and clearance of C-type natriuretic peptide in the interaction of vascular endothelial cells and smooth muscle cells. J. Hypertens. 14(5): 585-592, 1996.
23. Ishikawa M, Saito Y, Miyamoto Y, Kuwahara K, Ogawa E, Nakagawa O, Harada M, Masuda I, Nakao K. cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats. Biochem. Biophys. Res. Commun. 219(2): 377-381, 1996.
22. Komatsu Y, Itoh H, Suga S, Ogawa Y, Hama N, Kishimoto I, Nakagawa O, Igaki T, Doi K, Yoshimasa T, Nakao K.
Regulation of endothelial production of C-type natriuretic peptide in coculture with vascular smooth muscle cells. - The role of vascular natriuretic peptide system in vascular growth inhibition. Circ. Res. 78(4): 606-614, 1996.
21. Masuzaki H, Jingami H, Matsuoka N, Nakagawa O, Ogawa Y, Mizuno M, Yoshimasa Y, Yamamoto T, Nakao K. Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart. Circ. Res. 78(1): 8-14, 1996.
20. Nakagawa O, Sasaki Y, Tanaka I, Usui T, Itoh H, Yoshimasa T, Narumiya S, Nakao K. Gene expression of prostacyclin receptor in the hypertrophied heart of spontaneously hypertensive rats. Clin. Experi. Pharmacol. Physiol. 22(Suppl 1): S270-S272, 1995.
19. Jingami H, Masuzaki H, Matsuoka N, Nakagawa O, Ogawa Y, Mizuno M, Yamamoto T, Nakao K. Decreased expression of the very low density lipoprotein receptor mRNA in the cardiac ventricle of spontaneously hypertensive rats. Clin. Experi. Pharmacol. Physiol. 22(Suppl 1): S246-S248, 1995.
18. Kishimoto I, Yoshimasa T, Arai H, Takaya K, Miyamoto Y, Yamashita J, Suga S, Komatsu Y, Nakagawa O, Tanaka I, Itoh H, Nakao K. Endothelin-induced activation of mitogen-activated protein kinases in glomerular mesangial cells from normotensive and stroke-prone spontaneously hypertensive rats. Clin. Experi. Pharmacol. Physiol. 22(Supple 1): S207-S208, 1995.
17. Nakagawa O, Itoh H, Harada M, Yoshimasa T, Nakao K. Gene regulation of brain natriuretic peptide in cardiocyte hypertrophy by alpha1-adrenergic stimulation. Clin. Experi. Pharmacol. Physiol. 22(Suppl 1): S183-S185, 1995.
16. Ogawa Y, Itoh H, Nakagawa O, Shirakami G, Tamura N, Yoshimasa T, Nagata K, Yoshida N, Nakao K. Characterization of the 5'-flanking region and chromosomal assignment of the human brain natriuretic peptide. J. Mol. Med. 73(9): 457-463, 1995.
15. Hama N, Itoh H, Shirakami G, Nakagawa O, Suga S, Ogawa Y, Masuda I, Nakanishi K, Yoshimasa T, Hashimoto Y, Yamaguchi M, Hori R, Yasue H, Nakao K. Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction. Circulation 92(6): 1558-1564, 1995.
14. Nakagawa O, Ogawa Y, Itoh H, Suga S, Komatsu Y, Kishimoto I, Nishino K, Yoshimasa T, Nakao K. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. -Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload-. J. Clin. Invest. 96(3): 1280-1287, 1995.
13. Ogawa Y, Tanaka I, Yoshitake Y, Inoue M, Isse N, Nakagawa O, Usui T, Itoh H, Yoshimasa T, Narumiya S, Nakao K. Structural organization and chromosomal assignment of the human prostacyclin receptor gene. Genomics 27(1): 142-148, 1995.
12. Sasaki Y, Usui T, Tanaka I, Nakagawa O, Sando T, Takahashi T, Namba T, Narumiya S, Nakao K. Cloning and expression of a cDNA for rat prostacyclin receptor. Biochim. Biophys. Acta 1224(3): 601-605, 1994.
11. Kishimoto I, Yoshimasa T, Suga S, Ogawa Y, Komatsu Y, Nakagawa O, Itoh H, Nakao K. Natriuretic peptide clearance receptor is transcriptionally down-regulated by alpha2-adrenergic stimulation in vascular smooth cells. J. Biol. Chem. 269(45): 28300-28308, 1994.
10. Nakagawa O, Tanaka I, Usui T, Harada M, Sasaki Y, Itoh H, Yoshimasa T, Namba T, Narumiya S, Nakao K. Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. Circulation 90(4): 1643-1647, 1994.
9. Tamura N, Ogawa Y, Itoh H, Arai H, Suga S, Nakagawa O, Komatsu Y, Kishimoto I, Takaya K, Yoshimasa T, Shiono S, Nakao K. Molecular cloning of hamster brain natriuretic peptide cDNAs. -Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides-. J. Clin. Invest. 94(3): 1059-1068, 1994.
8. Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O, Kikuchi H, Imura H. C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. Brain Res. 612(1-2): 104-109, 1993.
7. Suga S, Nakao K, Kishimoto I, Hosoda K, Mukoyama M, Arai H, Shirakami G, Ogawa Y, Komatsu Y, Nakagawa O, Hama N, Imura H. Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells. Circ. Res. 71(1): 34-39. 1992.
6. Ogawa Y, Nakao K, Nakagawa O, Komatsu Y, Hosoda K, Suga S, Arai H, Nagata K, Yoshida N, Imura H. Human C-type natriuretic peptide -Characterization of the gene and peptide-. Hypertension 19(6 Pt 2): 809-813, 1992.
5. Arai H, Nakao K, Hosoda K, Ogawa Y, Nakagawa O, Suga S, Nakanishi S, Imura H. Molecular cloning of two subtypes of human endothelin receptor. Therapeutic Res. 13: 273-279, 1992.
4. Nakao K, Arai H, Hosoda K, Ogawa Y, Nakagawa O, Suga S, Nakanishi S, Imura H. Molecular cloning of two subtypes of human endothelin receptor. J. Vasc. Med. Biol. 3: 303-307, 1991.
3. Komatsu Y, Nakao K, Suga S, Ogawa Y, Mukoyama M, Arai H, Shirakami G, Hosoda K, Nakagawa O, Hama N, Kishimoto I, Imura H. C-type natriuretic peptide (CNP) in rats and humans. Endocrinology 129(2): 1104-1106, 1991.
2. Ogawa Y, Nakao K, Arai H, Nakagawa O, Hosoda K, Suga S, Nakanishi S, Imura H. Molecular cloning of a non-isopeptide-selective human endothelin receptor. Biochem. Biophys. Res. Commun. 178(1): 248-255, 1991.
1. Nakagawa O, Nakao K, Saito Y, Shirakami G, Jougasaki M, Mukoyama M, Hosoda K, Suga S, Ogawa Y, Kishimoto I, Komatsu Y, Hama N, Imura H. Isolation and characterization of porcine endothelin-like peptide. J. Cardiovasc. Pharmacol. 17(Suppl 7): S13-S16, 1991.
