The Division on Addiction encompasses several laboratories performing both preclinical and clinical studies on the addictions. Basic science studies begin with the investigation of molecular and cellular adaptations that follow the chronic administration of substances (Laboratory of Molecular Psychiatry; Eric Nestler, M.D., Ph.D.) to the alterations in adult neurogenesis that occur in response to chronic drug exposure (Amelia Eisch’s laboratory). The Neurophysiology Laboratory (Don Cooper, Ph.D.) uses a combination of behavioral, molecular genetic, and electrophysiological techniques to understand the how psychostimulant drugs alter neuronal impulse activity and David Self, Ph.D. combines neurobiological and behavioral measures to understand the underlying neuroreceptors processes involved in escalating drug consumption.
Clinical laboratory studies extend the findings from our preclinical laboratory into the human subject. Uma Rao, M.D. uses a complex combination of behavioral, personality, cognitive and neuroimaging measures to assess the risk factors for kids at high risk for the development of addiction problems. Similar techniques, including neuroimaging and neuroendocrine probes, are used by Bryon Adinoff, M.D., to explore the neurobiologic changes that may predict future relapse in addicted patients. The Texas Node of the Clinical Trials Network is part of a nation wide effort to development and implement multi-site pharmacologic and behavioral studies for the treatment of addictive disorders. As part of this effort, Carlos Tirado, M.D., is assessing the impact of cheese heroin upon adolescents in the Dallas area. The frequent c0mbination of substance use disorders and other psychiatric illnesses is being explored by Sherwood Brown, M.D., Ph.D. , who is using novel medications to treat patients with both bipolar disease and cocaine or alcohol dependence.
ACTIVE RESEARCH STUDIES
Addictive Disorders Laboratory
Impulsivity, Neural Deficits, and Cocaine Relapse
Funding Agency: National Institute on Drug Abuse
PI: Bryon Adinoff, M.D.
Stress, HPA Axis Dysfunction, and Relapse in Alcoholism
Funding Agency: National Institute on Alcohol Abuse and Alcoholism, Integrative Neuroscience Initiative on Alcoholism (INIA)
PI: Bryon Adinoff, M.D.
Psychiatrist Research Education & Training in Drug Abuse
Funding Agency: National Institute on Drug Abuse
PI: Bryon Adinoff, M.D.
Adolescent Mood and Addictive Disorders Research Program
Markers of Risk for Nicotine Dependence in Youngsters
Funding Agency: National Institute on Drug Abuse
PI: Uma Rao, M.D.
Neuronal Risk Markers for Nicotine Dependence in Youth
Funding Agency: National Institute on Drug Abuse
PI: Uma Rao, M.D.
Stress Response and Smoking Cessation in Depressed Youth
Funding Agency: National Institute on Drug Abuse
PI: Uma Rao, M.D.
Stress and Risk for Substance Abuse in Adolescents
Funding Agency: National Institute on Drug Abuse
PI: Uma Rao, M.D.
Risk for Substance Abuse in Depressed Adolescents
Funding Agency: National Institute of Mental Health
PI: Uma Rao, M.D.
Treatment Prediction in Adolescent and Adult Depression
Funding Agency: National Institute of Mental Health
PI: Uma Rao, M.D.
Basic Science Laboratories
Clinical Trials Network
Clinical Trials Network: Texas Node
Funding Agency: National Institute on Drug Abuse
PI: Bryon Adinoff, M.D.
Osmotic-Release Methylphenidate (OROS MPH) for ADHD in Adolescents with Substance Use Disorders (CTN 0028)
Funding Agency: National Institute on Drug Abuse
Site PI: Kathie Trello-Reishel, M.D.
Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement (CTN 0031)
Texas Node Site: Nexus Recovery Center
Site PI: Cindy Seamans, Ph.D.
Epidemiologic and Ethnographic Survey of “Cheese” Heroin use Among Latino Adolescents in Dallas County (CTN0036)
Site PI: Carlos Tirado, M.D., M.P.H.
Eisch Lab
New Horizons in Adult Neurogenesis
Funding Agency: National Institute on Drug Abuse
PI: Amelia Eisch, Ph.D.
Regulation of adult neurogenesis by opiates
Funding Agency: National Institute on Drug Abuse
PI: Amelia Eisch, Ph.D.
Cdk5 and adult hippocampal neurogenesis
Funding Agency: National Institute on Drug Abuse
PI: Amelia Eisch, Ph.D.
Basic Science Training Program in Drug Abuse
Funding Agency: National Institute on Drug Abuse
PI: Amelia Eisch, Ph.D.
Family Studies Center
Couple Therapy and Pharmacotherapy for Major Depression
Funding Agency: National Institute of Mental Health
PI: Wayne Denton, Ph.D.
Laboratory of Molecular Psychiatry
Molecular Studies of Opiate and Cocaine Action in Brain
Funding Agency: National Institute on Drug Abuse
PI: Eric Nestler, M.D., Ph.D.
Neural Substrates of Appetitive Behavior in Mood and Motivation
Funding Agency: National Institute of Mental Health
PI: Eric Nestler, M.D., Ph.D.
Molecular Studies of Cocaine Action in Brain
Funding Agency: National Institute on Drug Abuse
PI: Eric Nestler, M.D., Ph.D.
Neurotrophic Factors and Drugs of Abuse
Funding Agency: National Institute on Drug Abuse
PI: Eric Nestler, M.D., Ph.D.
Pharmacological Actions of Stress and Antidepressants
Funding Agency: National Institute of Mental Health
PI: Eric Nestler, M.D., Ph.D.
Basic Science Training Program in Drug Abuse
Funding Agency: National Institute on Drug Abuse
PI: Eric Nestler, M.D., Ph.D.
Basic Science Training Program in the Neurobiology of Mental Illness
Funding Agency: National Institute on Drug Abuse
PI: Eric Nestler, M.D., Ph.D.
Mood Disorders Research Program and Clinic
Computerized Decision Support System for Depression
Funding Agency: National Institute of Mental Health
PI: Madhukar Trivedi, M.D.
Using Information Technology to Provide Measurement Based Care for Chronic Illness
Funding Agency: Agency for Healthcare Research and Quality
PI: Madhukar Trivedi, M.D.
Mood Disorders Clinical Intervention Training Program
Funding Agency: National Institute of Mental Health
PI: Madhukar Trivedi, M.D.
REVAMP Follow-Up
Funding Agency: National Institute of Mental Health
PI: Madhukar Trivedi, M.D.
Neurophysiology Laboratory
DNA Microarray Analysis of Neuronal Excitability
Funding Agency: National Institute on Drug Abuse
PI: Don Cooper, Ph.D.
Plasticity of excitability in ventral subiculum after high cocaine intake
Funding Agency: National Institute on Drug Abuse
PI: Don Cooper, Ph.D.
Psychoneuroendocrine Research Program
Quetiapine for Bipolar Disorder and Alcohol Dependence
Funding Agency: National Institute on Alcohol Abuse and Alcoholism
PI: E. Sherwood Brown, M.D.
Citicoline for Bipolar Disorder and Cocaine Dependence
Funding Agency: National Institute on Drug Abuse
PI: E. Sherwood Brown, M.D.
Development of a Model to Examine Corticosteroid Effects on the Hippocampus
Funding Agency: National Institute of Mental Health
PI: E. Sherwood Brown, M.D.
The Self Laboratories
Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
Funding Agency: National Institute on Drug Abuse
PI: David Self, Ph.D.
VTA Ionotropic Glutamate Receptors in Cocaine Addiction
Funding Agency: National Institute on Drug Abuse
PI: David Self, Ph.D.
PUBLICATIONS
