Chou-Long Huang, M.D., Ph.D.
Professor of Internal Medicine
Research Interests:
Ion channel physiology, biophysics, and signaling mechanisms of ion channel regulation
Human (genetic) diseases caused by ion channel disorders
Biology of the WNK kinase cascade and the anti-aging protein Klotho
Recent Publications:
He, G., Wang, H.-R., Huang, S.-K., and Huang, C.-L. Intersectin links WNK kinases to endocytosis of ROMK. J. Clin. Invest. 117: 1078-1087, 2007.
Cha, S.-K., Ortega, B., Kurosu, H., Rosenblatt K. P., Kuro-o, M, and Huang, C.-L. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc. Natl. Acad. Sci USA 105: 9805-9810, 2008.
Liu, Z., Wang, H-R., and Huang, C.-L. (2009) Regulation of ROMK channel and K homeostasis by kidney-specific WNK1 kinase. J. Biol. Chem. 284: 12198-12206, 2009.
Xie, J., Wu, T., Xu, K., Huang, I. K., Cleaver, D., and Huang, C.-L. Endothelial expression of WNK1 is essential for angiogenesis and cardiovascular development in mice. Am. J. Pathology 175: 1315-1327, 2009.
Liu, Z., Xie, J., Wu, T., Thao, T., Auchus, R. J., and Huang, C.-L. Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum. Mol. Genet. 20: 855-866, 2011.
Significant Publications:
Huang C.-L., Slesinger, P.A., Casey, P.J., Jan, Y.N. and Jan, L.Y. Evidence that direct binding of G protein Βγ subunit to the GIRK1 G protein gated-inwardly rectifying K channel is important for channel activation. Neuron 15: 1133-1143, 1995.
Huang, C.-L., Feng, S. and Hilgemann, D.W. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GΒγ. Nature 391: 803-806, 1998.
Liou, H.-H., Zhou, S.S., and Huang C.-L. Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proc. Natl. Acad. Sci. USA 96: 5820-5825, 1999.
Yeh, B.-I., Kim, Y. K., Jabbar, W., and Huang, C.-L. Conformational changes of pore helix coupled to gating of TRPV5 by protons. EMBO J. 24: 3224-3234, 2005.
Lazrak, A., Liu, Z., and Huang, C.-L. Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc. Natl. Acad. Sci. USA 103: 1615-1620, 2006.
