Session 1 - July 7, 2009 (Tuesday) - 12:00-1:30 pm (D1.104)
(Reisch, Hynan, Elliott)

Introductory Session - The format for the course will be discussed, schedules and course materials will be distributed.

(Reisch) 1. Oxman, AD, Sackett, DL, Guyatt, GH (1993), "Users' Guides to the Medical Literature: I. How to Get Started," JAMA, 270:2093-2095.

(Hynan) 2. Colton, T (1974), "Chapter 13, Critical Reading of the Medical Literature," Statistics in Medicine, Little, Brown and Co., Boston, MA, 315-322.

(Elliott) 3. Introduction to WINKS - a user-friendly statistical package

Session 2 - July 9, 2009 (Thursday) - 12:00-1:00 pm (D1.104)
(Hynan/Minhajuddin)

(_____) 1. Guyatt GH, et al (1993), "Users' Guides to the Medical Literature: IIA. How to Use an Article About Therapy or Prevention: Are the Results of the Study Valid?" JAMA, 270:2598-2601.

(_____) 2. Guyatt GH, et al (1994), "Users' Guides to the Medical Literature: IIB. How to Use an Article About Therapy or Prevention: What Were the Results and Will They Help Me in Caring for My Patients?" (1994) JAMA, 271:59-63.

(_____) 3. Angell M (1989), "Negative Studies," NEJM, 321:464-466 and Begley S (2006), "New Journals Bet 'Negative Results' Save Time, Money," Wall Street Journal.

(_____) 4. Kitahata MM, et al (2009), "Effect of Early Versus Deferred Antiretroviral Therapy for HIV on Survival," NEJM, 360:1815-1826.

(_____) 5. Jones RH, et al (2009), "Coronary Bypass Surgery With or Without Surgical Ventricular Reconstruction," NEJM, 360:1705-1717.

Session 3 - July 14, 2009 (Tuesday) - 12:00-1:30 pm (D1.104)
(Reisch/Bhore)

(_____) 1. Levine M, et al (1994) "Users' Guides to the Medical Literature: IV. How to Use an Article About Harm," JAMA, 271:1615-1619.

(_____) 2. Lavori P, et al (1983), "Designs for Experiments - Parallel Comparisons of Treatment," NEJM, 309:1291-1299.

(_____) 3. Boyer LV, et al (2009), "Antivenom for Critically Ill Children With Neurotoxicity from Scorpion Stings," NEJM, 360:2090-2098.

(_____) 4. Plint AC, et al (2009), "Epinephrine and Dexamethasone in Children With Bronchiolitis," NEJM, 360:2079-2089.

Session 4 - July 16, 2009 (Thursday) - 12:00-1:00 pm (D1.104)
(Hynan/Minhajuddin)

(_____) 1. Laupacis A, et al (1994), "Users' Guides to the Medical Literature: V. How to Use an Article About Prognosis," JAMA, 272:234-237.

(_____) 2. Louis TA, et al (1984), "Crossover and Self-Controlled Designs in Clinical Research," NEJM, 310:24-31.

(_____) 3. Freiman JA, et al (1978), "The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial," NEJM, 299:690-696.

(_____) 4. Mullighan CG, et al (2009), "Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia," NEJM, 360:470-480.

(_____) 5. Moers C, et al (2009), "Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation," NEJM, 360-7-19.

Session 5 - July 21, 2009 (Tuesday) - 12:00-1:30 pm (D1.104)
(Elliott/Bhore/Zhang)

(_____) 1. Jaeschke R, et al (1994), "Users' Guides to the Medical Literature: IIIA. How to Use an Article About a Diagnostic Test: Are the Results of the Study Valid?" JAMA, 271:389-391.

(_____) 2. Jaeschke R, et al (1994), "Users' Guides to the Medical Literature: IIIB. How to Use an Article About a Diagnostic Test: What Were the Results and Will They Help Me in Caring for My Patients?" JAMA, 271:703-707.

(_____) 3. Singh H, et al (2006), "Risk of Developing Colorectal Cancer Following a Negative Colonoscopy Examination. Evidence for a 10-Year Interval Between Colonoscopies," JAMA 295:2366-2373.

(_____) 4. Peacock WF, et al (2009) "Cardiac Troponin and Outcome in Acute Heart Failure," NEJM, 358:2117-2126.

Session 6 - July 23, 2009 (Thursday) - 11:30-1:00 pm (D1.104)
(Reisch/Zhang)

(_____) 1. Oxman AD, et al. (1994), "Users' Guides to the Medical Literature: VI. How to Use an Overview," JAMA, 272:1367-1371.

(_____) 2. Oxman A, Guyatt GH (1992), "A Consumer's Guide to Subgroup Analyses," Ann. Internal Med., 116:78-84.

(_____) 3. Wiener RS, et al (2008), "Benefits and Risks of Tight Glucose Control in Critically Ill Adults. A Meta-Analysis," JAMA, 300:933-944.

(_____) 4. Glynn RJ, et al (2009), "A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism," NEJM, 360:1851-1861.

Session 7 - July 28, 2009 (Tuesday) - 12:00-1:30 pm (D1.104)
(Hynan/Zhang)

(_____) 1. Patton DD, (1978) "Introduction to Clinical Decision Making," Sem. Nuclear Med., 8:273-282.

(_____) 2. McGinn TG, et al (2000), "Users' Guides to the Medical Literature: XXII. How to Use Articles About Clinical Decision Rules," JAMA, 284:79-84.

(_____) 3. Nigrovic LE, et al (2007), "Clinical Prediction Rule for Identifying Children With Cerebrospinal Fluid Pleocytosis at Very Low Risk of Bacterial Meningitis," JAMA, 297:52-60.

(_____) 4. Ikram MA, et al (2009), "Genomewide Association Studies of Stroke," NEJM, 360:1718-1728.

Session 8 - July 30, 2009 (Thursday) - 11:30-1:00 pm (D1.104)
(Reisch/Elliott/Bhore)

Student papers for discussion - TBA - All DCS statisticians

(_____) 1. Hunt DL (2000), "Users' Guides to the Medical Literature: XXI. Using Electronic Health Information Resources in Evidence-Based Practice," JAMA, 283:1875-1879.

Student papers - Each student will be responsible for selecting a paper of their choice to present.