Inborn errors of metabolism  (Drs. Cox and Wynn)
The molecular genetic basis of mitochondrial multienzyme complex deficiencies, e.g. Maple Syrup Urine Disease (Drs. Rody Cox and Max Wynn)


Mitochondrial multienzyme complexes  (Drs. Rody Cox and Max Wynn)

• Structure and function of mitochondrial multienzyme protein complexes including X-ray structural analysis of the catalytic and regulatory subunits
• The role of chaperone proteins (heat shock proteins-Hsp's) and how they regulate the folding and assembly of these multi-subunit complexes
• Coordinate regulation of the genes encoding mitochondrial multienzyme protein complexes

Cancer Epidemiology  (Dr. Yvonne Coyle)

Current research involves general, molecular, and genetic epidemiology studies that focus on the etiology of breast and lung cancer. The purpose of two of these studies is to determine the effect of the environment on breast cancer risk. Another study, which is part of a large center grant, involves identifying the metabolizing gene polymorphisms that are associated with increased lung cancer risk with and without tobacco smoke exposure.