Cancer Cell Networks Scientific Program

The goal of the Cancer Cell Networks Scientific Program is to expand our understanding of the pathways regulating cell growth and cell death and their derangement in tumor initiation and progression.  Research conducted by program members ranges from the basic analysis of fundamental biological processes related to how cells recognize and respond to environmental signals and the changes in gene expression that follow to the analysis of altered states of these processes in cancer.  Specific aims of the program are to increase the awareness of the research on oncoproteins and tumor suppressor signaling and cell survival and cell death pathways and thereby encourage collaborative interactions within the program and to provide the basic science expertise for translational approaches to exploit aberrations in cell signaling and cell growth control pathways for diagnostic or therapeutic targets.

For more information contact a program leader: Melanie Cobb, PhD or Michael White, PhD.

• Define the mechanisms and pathways that integrate external and internal regulatory signals in cells.
• Determine how aberrant behavior of components above are involved in cell transformation and tumorigenesis.
• Facilitate interactions with translational and clinical scientists to develop strategies to test the therapeutic benefit of modulating the above components.

The Cancer Cell Networks Scientific Program seeks additional physicians and scientists to further collaboration focusing on large scale unbiased interrogation of cancer cell regulatory systems based on established RNAi high-throughput screening (HTS) and opportunities to leverage results from functional genomics efforts.

• Program meetings are attended by all investigators, postdoctoral fellows, students and scientist-level technical staff.
• Graduate program: Students from the Cancer Biology Program currently participate in the monthly program meetings as a component of their weekly W.I.P. or Work In Progress. 
• New Technology: The program is encouraging collaborative efforts among members with a common interest in leveraging new high throughput screening platforms for cancer research.

-- Program Member -- Altschuler, PhD, Steven Brugarolas, MD, PhD, James Burma, PhD, Sandeep Chen, PhD, Benjamin Chen, PhD, David Chen, PhD, Zhijian "James" Chiang, PhD, Cheng-Ming Cobb, PhD, Melanie Corey, PhD, David DeMartino, PhD, George Fountoura, PhD, Beatriz Galindo, MD, PhD, Rene Huang, PhD, Lily Janowski, PhD, Bethany Kliewer, PhD, Steven Leonard, PhD, David Levine, MD, Beth Li, PhD, Wen-hong Liu, PhD, Yi Lum, PhD, Lawrence Mangelsdorf, PhD, David Mendelson, PhD, Carole Rosen, PhD, Mike Scaglioni, MD, Pier Paolo Terman, PhD, Jonathan Turcotte, PhD, Marc White, PhD, Michael Wright, MD, PhD, Woodring Wu, PhD, Lani Wuelfing, PhD, Christoph Xie, PhD, Xian-Jin Yang, PhD, Chin-Rang Yu, PhD, Hongtao Zou, PhD, Hui