Publications from TORS the past year that utilized services offered by the core.

2009

1.      Cortés, V.A., Curtis, D.E., Sukumaran, S., Shao, X., Parameswara, S., Rashid, S., Smith, A.R., Ren, J.,  Esser, V., Hammer, R.E., Agarwal, A.K., Horton, J.D., and Garg, A. 2009 Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2 Deficient Mouse Model of Congenital Generalized Lipodystrophy. Cell  Metab. 9:165-176. PMCID: PMC2673980.

2.      Grefhorst A, Parks, E.J. 2009. Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice.  J Lipid Res. In press. PMCID: PMC Journal – In Process.

3.      Halford, R.W., Russell, D.W. 2009. Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer’s disease, but does extend lifespan. Proc. Natl. Acad. Sci. USA 106:3502-3506. PMCID: PMC2651246.

4.      Khuu A, Ren J, Dimitrov I, Woessner D, Murdoch J, Sherry AD, Malloy CR. Intramyocellular Lipid Concentration by 1H NMR. Magn Reson Med. 2009; 61: 16-21.

5.      Kim, K.W., Zhao, L., and Parker, K.L. 2009. Central nervous system-specific knockout of steroidogenic factor 1. Mol Cell Endocrinol 300:132-136. PMCID: Non-PMC Journal – In Process.

6.      Malloy, CR.  et al.  Composition of Intracellular Triglycerides. 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression, in press Mag Res Med.

7.      Potthoff,M.J., Inagaki, T., Sapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B.N., Mangelsdorf, D.J., Kliewer, S.A., Burgess, S.C. 2009. FGF21 induces PGC-1a and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.  Proc. Natl. Acad. Sci. USA. PMCID: PMC2705613

8.      Romeo S, Yin W, Kozlitina J, Pennacchio LA, Boerwinkle E, Hobbs HH, Cohen JC. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest. 2009:119;70-9. PMCID: PMC2613476

9.      Russell, D.W. 2009. 50 Years of Advances in Bile Acid Metabolism. J. Lipid. Res. 50:S120-S125. PMCID: PMC Journal – In Process.

10.    Russell, D.W., Halford, R.W., Ramirez, D.M.O., Shah, R., and Kotti, T. 2009 Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain. Annu. Rev. Biochem. 78: in press. Non-PMC Journal – In Process.

11.    Sakata I, Yang J, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells.  Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E134-41. Epub 2009 Apr 28. PMCID: PMC2711663 Click here to access article/PDF

10.  Scott, M.M., Lachey, J.L., Sternson, S.M., Lee, C.E., Elias, C.F., Friedman, J.M., and Elmquist, J.K. 2009. Leptin targets in the mouse brain. J Comp Neurol 514:518-532. NIHMSID: NIHMS113776.

12.  Yin W, Romeo S, Chang S, Grishin NV, Hobbs HH, Cohen JC.  Genetic variation in ANGPTL4 provides insights into protein processing and function. J Biol Chem. 2009:284;13213-22. PMCID: PMC2676053

2008

13.  Bingham, N.C., Anderson, K.K., Reuter, A.L., Stallings, N.R., and Parker, K.L. 2008. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149:2138-2148. PMCID:PMC 2329259. Click here to access article/PDF

14.  Browning JD, Weis B, Davis J, Satapati S, Merritt M, Malloy CR, Burgess SC. Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction. Hepatology. 2008 Nov;48(5):1487-96. PMCID: PMC2701295. Click here to access article/PDF

15.  Inagaki, T., Lin, V.Y., Goetz, R., Mohammadi, M., Mangelsdorf, D.J., Kliewer, S.A. 2008. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab. 8: 77-83.  PMCID: PMC2575072.

16.  Kim, K.W., Jo, Y.H., Zhao, L., Stallings, N.R., Chua, S.C., Jr., and Parker, K.L. 2008. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol 22:1950-1961. PMCID:PMC2505330.

17.  Kotti, T., Head, D. D., McKenna, C.M., and Russell, D. W. 2008. Biphasic Requirement for Geranylgeraniol in Hippocampal Long-Term Potentiation.  Proc. Natl. Acad. Sci. USA 105:11394-11399. PMCID: PMC2516227.

18.  Kublaoui, B.M., Gemelli, T., Tolson, K.P., Wang, Y., and Zinn, A.R. 2008. Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol 22:1723-1734. PMCID: PMC2453606.  Click here to access article/PDF

19.  Lutter, M., Krishnan, V., Russo, S.J., Jung, S., McClung, C.A., and Nestler, E.J. 2008. Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci 28:3071-3075. NIHMSID: NIHMS113375.

20.  Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S.A., Anderson, J.G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J.K., Nestler, E.J., Zigman, JM. 2008. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 11:752-753. NIHMSID: NIHMS113339.  Click here to access article/PDF

21.  Ren J, Dimitrov I, Sherry AD, Malloy CR. Composition of Adipose Triglycerides by 1H NMR. J Lipid Res. 2008; 49: 2055-62.

22.  Romeo S, kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC, Hobbs HH. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008:40;1461-5. PMCID: PMC2597056

23.  Satapati, S., He, T., Inagaki, T., Potthoff, M,. Merritt ,M., Esser, V., Mangelsdorf, D.J., Kliewer, S.A., Browning, J.D., Burgess, S.C. 2008. Partial resistance to PPARa agonists in Zucker diabetic fatty (ZDF) rats is associated with impaired hepatic mitochondrial function. Diabetes.  In press. Click here to access article/PDF

24.  Xu, Y., Jones, J.E., Kohno, D., Williams, K.W., Lee, C.E., Choi, M.J., Anderson, J.G., Heisler, L.K., Zigman, J.M., Lowell, B.B. Elmquist, JK. 2008. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60:582-589. PMCID: PMC2631191.

25.  Yang, J., Brown, M.S., Liang, G. Grishin, N.V., and Goldstein, J.L. 2008. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.  Cell.  132:387-396. Click here to access article/PDF

26.  Yang, J., Zhao, T. J., Goldstein, J. L., Brown, M. S. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. 2008. Proc. Natl. Acad. Sci. USA. 105:10750-10755. PMCID: PMC2504781

27.  Zhao, L., Kim, K.W., Ikeda, Y., Anderson, K.K., Beck, L., Chase, S., Tobet, S.A., and Parker, K.L. 2008. Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. Mol Endocrinol 22:1403-1415. PMCID: PMC2422821. Click here to access Article/PDF

2007

28.  Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J.K., Gerard, R.D., Burgess, S.C., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. Endocrine regulation of the fasting response by PPARalpha-mediated induction of Fibroblast Growth Factor 21. Cell Metab. 2007 Jun;5(6):415-425. Click here to access article/PDF

29.  Romeo, S., Pennacchio, L.A., Fu, Y., Boerwinkle, E., Tybjaerg-Hansen, A. Hobbs, H.H., Cohen, J.C. 2007. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat. Genet. 39(4):513-516. Click here to access article/PDF

Updated 10/22/2009