Kent Hamra

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Kent Hamra




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	Hammer Lab

	Hsieh Lab

	McKearin Lab

	Megraw Lab

	Kent Hamra

	Timothy Quill

F. Kent Hamra

Assistant Professor (NT Track)

Project:
In vitro culture of rat spermatogenic cells with subsequent differentiation

e-mail: Kent.Hamra@UTSouthwestern.edu

EDUCATION/TRAINING

Institution and Location	Degree	Years	Field
Southern Illinois University, Carbondale, IL	B.S.	1989	Zoology
University of Missouri, St. Louis, MO		1991	Masters Program Biology
University of Missouri, Columbia, MO	Ph.D.	1995	Pharmacology

RESEARCH AND PROFESSIONAL EXPERIENCE

1989 - 1990		Research Technician Monsanto Company, St. Louis, MO, Monsanto Corporate Research, Bioprocess Technology
1991 - 1992		Research Technician Monsanto Company, St. Louis, MO, Monsanto Corporate Research, Molecular Pharmacology
1992 - 1995		Graduate Student University of Missouri School of Medicine, Columbia, MO, Department of Pharmacology.
1995 - 1996		Postdoctoral Fellow University of Missouri School of Medicine, Columbia, MO, Department of Pharmacology
1996 - 2000		Postdoctoral Associate Howard Hughes Medical Institute, at University of Texas Southwestern Medical Center at Dallas, Department of Pharmacology.
2000 - 2004		Instructor University of Texas Southwestern Medical Center at Dallas, Department of Pharmacology.
2004 - present		Assistant Professor University of Texas Southwestern Medical Center at Dallas, Deparment of Pharmacology and Cecil H. & Ida Green Center for Reproductive Biological Sciences.

PUBLICATIONS

Hamra FK, Chapman KM, Nguyen DM, Williams-Stephens AA, Hammer RE, Garbers DL.Self renewal, expansion, and transfection of rat spermatogonial stem cells in culture. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17430-5. Epub 2005 Nov 17.

Diederichs S, Baumer N, Schultz N, Hamra FK, Schrader MG, Sandstede ML, Berdel WE, Serve H, Muller-Tidow C. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development.
Int J Cancer. 2005 Aug 20;116(2):207-17.

Garbers DL, Schultz N, Wu N, Hamra FK. Spermatogonial stem cells in the rat and mouse. IN: Handbook of Stem Cells, Volume 1: Embryonic Stem Cells. 2004: 179-185.

Hamra FK, Schultz N, Chapman KM, Grellhesl DM, Cronkhite JT, Hammer RE, Garbers DL. Defining the spermatogonial stem cell. Dev Biol. 2004 May 15;269(2):393-410.

Schultz N, Hamra FK, Garbers DL. A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12201-6. Epub 2003 Oct 02.

Hamra FK, Gatlin J, Chapman KM, Grellhesl DM, Garcia JV, Hammer RE, Garbers DL. Production of transgenic rats by lentiviral transduction of male germ-line stem cells. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14931-6.
Highlight Article in Nature Reviews Genetics, December 2002.

Kishimoto I, Hamra FK, Garbers DL. Apparent B-type natriuretic peptide selectivity in the kidney due to differential processing. Can J Physiol Pharmacol. 2001 Aug;79(8):715-22.

Fan X, Hamra FK, London RM, Eber SL, Krause WJ, Freeman RH, Smith CE, Currie MG, Forte LR. Structure and activity of uroguanylin and guanylin from the intestine and urine of rats. Am J Physiol. 1997 Nov;273(5 Pt 1):E957-64.

Krause WJ, Freeman RH, Eber SL, Hamra FK, Currie MG, Forte LR. Guanylyl cyclase receptors and guanylin-like peptides in reptilian intestine. Gen Comp Endocrinol. 1997 Aug;107(2):229-39.

Greenberg RN, Hill M, Crytzer J, Krause WJ, Eber SL, Hamra FK, Forte LR. Comparison of effects of uroguanylin, guanylin, and Escherichia coli heat-stable enterotoxin STa in mouse intestine and kidney: evidence that uroguanylin is an intestinal natriuretic hormone. J Investig Med. 1997 Jun;45(5):276-82.

Hamra FK, Eber SL, Chin DT, Currie MG, Forte LR. Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2705-10.

Forte LR, Fan X, Hamra FK. Salt and water homeostasis: uroguanylin is a circulating peptide hormone with natriuretic activity. Am J Kidney Dis. 1996 Aug;28(2):296-304. Review.

Hamra FK, Krause WJ, Eber SL, Freeman RH, Smith CE, Currie MG, Forte LR. Opossum colonic mucosa contains uroguanylin and guanylin peptides. Am J Physiol. 1996 Apr;270(4 Pt 1):G708-16.

Fan X, Hamra FK, Freeman RH, Eber SL, Krause WJ, Lim RW, Pace VM, Currie MG, Forte LR. Uroguanylin: cloning of preprouroguanylin cDNA, mRNA expression in the intestine and heart and isolation of uroguanylin and prouroguanylin from plasma. Biochem Biophys Res Commun. 1996 Feb 15;219(2):457-62.

Hamra FK, Fan X, Krause WJ, Freeman RH, Chin DT, Smith CE, Currie MG, Forte LR. Prouroguanylin and proguanylin: purification from colon, structure, and modulation of bioactivity by proteases. Endocrinology. 1996 Jan;137(1):257-65.

Krause WJ, Freeman RH, Eber SL, Hamra FK, Fok KF, Currie MG, Forte LR. Distribution of Escherichia coli heat-stable enterotoxin/guanylin/uroguanylin receptors in the avian intestinal tract. Acta Anat (Basel). 1995;153(3):210-9.

Kita T, Smith CE, Fok KF, Duffin KL, Moore WM, Karabatsos PJ, Kachur JF, Hamra FK, Pidhorodeckyj NV, Forte LR, et al. Characterization of human uroguanylin: a member of the guanylin peptide family. Am J Physiol. 1994 Feb;266(2 Pt 2):F342-8.

Hamra FK, Forte LR, Eber SL, Pidhorodeckyj NV, Krause WJ, Freeman RH, Chin DT, Tompkins JA, Fok KF, Smith CE, et al. Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10464-8.

Currie MG, Fok KF, Kato J, Moore RJ, Hamra FK, Duffin KL, Smith CE. Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):947-51.