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Class 11: 2008-2012
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Assistant Professor, Department of Physiology
Dr. Wu is interested in chromatin regulation of mammalian neural development. Her laboratory is studying the function of chromatin remodeling complexes in key signaling pathways that regulate neural stem cell self-renewal, differentiation, as well as post-mitotic neuronal development.
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Assistant Professor, Department of Pharmacology
Dr. Wan is interested in the transcriptional regulation of development, metabolism and cancer, currently focusing on how nuclear receptors regulate the differentiation and function of the bone-resorbing osteoclasts and the bone-forming osteoblasts. Her lab employs a wide spectrum of cutting-edge tools, including mouse genetic and disease models, molecular and cellular biology, genomics, metabolomics, stem cells and small molecules.
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Assistant Professor, Department of Molecular Biology
Dr. Zhang is interested in the molecular and cellular mechanisms regulating brain function, especially adult neural stem cells, neurogenesis, and psychological diseases, such as attention-deficit hyperactivity disorder (ADHD) and mental retardation. His laboratory is focused on nuclear hormone receptor signaling in these neurological processes.
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Assistant Professor, Department of Molecular Biology
Dr. Li is interested in understanding the epigenetic events that regulate transcription initiation and elongation in normal and diseased cells. In particular, the research in his laboratory will focus on the molecular mechanism by which chromatin related complexes help the transcription machinery overcome the nucleosomal barriers while maintaining genome integrity.
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Assistant Professor, Department of Internal Medicine
Dr. Patrie's lab is developing the state of the art in state-of-the-art in mass spectrometry and protein biochip technologies to discover and characterize the function of post-translational modifications (PTMs) in autoimmune disorders, cardiovascular diseases and cancers. We are particularly interested in understanding how PTMs drive interactions between chromatin-associated proteins in gene transcription. We are also developing a translational proteomics pipeline that rapidly identifies and validates PTM-based biomarkers thereby enabling a new class of early detection or prognostic tools for hospital laboratories.
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