The Department of Radiology
The Simmons Comprehensive Cancer Center
The Office of Continuing Medical Education
The NIH Southwestern Small Animal Imaging Resource Program
Present
The 9th Annual UT Southwestern
In vivo Cancer Cellular and Molecular Imaging Symposium
Innovations in Optical Imaging of Cancer
Thursday, November 12, 2009
8:15 AM – 5:00 PM
T. Boone Pickens Biomedical Building
6001 Forest Park Road
Dallas, TX 75235
Overview
The advent of reporter genes has revolutionized pre-clinical small animal research, notably facilitating fluorescence and bioluminescence imaging. Fluorescent proteins and tags allow cells and molecular events to be tracked non-invasively, followed by robust correlated histology. Novel reporter reagents such as dyes and quantum dots facilitate pharmacokinetic investigations and reveal expression and location of specific molecular targets. New materials promise lower toxicity and deeper light penetration of tissue. Light emission methods largely circumvent issues of tissue autofluorescence as pioneered with bioluminescent imaging (BLI) and recently extended to chemiluminescent imaging (CLI) in vivo. Optical imaging allows microscopic sub-palpable tumor volumes to be detected and each animal can serve as its own control.
Innovations in materials science, molecular biology, chemistry engineering, and computational analysis promise further progress and translation to clinical diagnosis and prognosis. This symposium presents innovators and leaders in the field, who continue to push the frontiers of biomedicine.
This symposium will examine developments and applications of optical imaging at levels from the microscope to the clinic, from molecular targets to pathophysiology, and from preclinical analysis to clinical trials. UT Southwestern and the State of Texas are committed to cancer research and effective imaging. We established the Cancer Imaging Program, which is supported by the National Cancer Institute U24 Southwestern Small Animal Imaging Research Program. A Comprehensive Cancer Center is a high priority, and recently the new Advanced Imaging Research Center was established. This symposium lays a further foundation towards creating the Southwestern Center for Prognostic Radiology.
Educational Objectives
1) Familiarity with New Technologies
2) Learn State of the Art Approaches in Pre-Clinical Modalities and Clinical Trials
3) Establish New Collaborations
Key Note Presentations
Prof. Dr. Clemens W.G.M. Lowik
Head, Molecular Endocrinology and Molecular Imaging
Department of Endocrinology
Leiden University Medical Center
The Netherlands
Christopher H. Contag, Ph.D.
Associate Professor
Departments of Pediatrics, Microbiology & Immunology and Radiology
Director, Stanford Infrared Optics and Photomedicine Center
Co-director, Molecular Imaging Program at Stanford (MIPS)
Stanford University School of Medicine
Stanford, California
Eva Sevick, Ph.D.
Professor and Cullen Chair in Molecular Medicine
The Brown Foundation Institute of Molecular Medicine
Director, Center for Molecular Imaging
NCI Network for Translational Research
The University of Texas Health Science Center -Houston
Houston, Texas
Hisataka Kobayashi, M.D., Ph.D.
Chief Scientist
Molecular Imaging Program/Center for Cancer Research
National Cancer Institute
National Institutes of Health
Bethesda, Maryland
Commercial Imaging Instrument Demonstrations
Friday, November 13, 2009
Various Laboratories – TBD
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, TX 75390
Overview
Several manufacturers have been invited to present their latest innovations and instruments in relation to small animal imaging. Please visit with the representatives of these commercial instrument companies during breaks at the Symposium, and arrange to attend a demonstration.
For Information Contact: CancerImagingProgram@UTSouthwestern.edu
