Genetic Determinants of Keloid Formation Study

Study ID
Study00002379

Cancer Related
No

Healthy Volunteers
No

Study Sites

Contact
Irene Dougherty
214-633-1842
irene.dougherty@utsouthwestern.edu

Principal Investigator
Donald Glass

Summary

a better understanding of the causes of keloids can be obtained through identifying the genetic causes of this disorder. our objective is to identify genes that are critical to patients being susceptible to keloidal scarring by identifying genetic loci and genes that are common within multiple affected family members.

We will invite any person ages 1-90 years old that has or has had keloidal scarring to participate in this study, as well as any first or second degree family member of a participant that has or has had keloids, whether that family member be affected or unaffected by keloids. our goal is to enroll up to 50 distinct families, each with at least 5 affected family members and at least 20 members overall.

each participant will undergo a comprehensive health survey, documentation and photography of their keloidal lesions, sampling and banking of blood, Dna, Rna, and cells (lymphocytes), for analysis of loci segregation and sequence variations.

Participant Eligibility

-male or female subjects 1-90 yrs old who have or have had keloidal scarring
-first- or second-degree relatives aged 1-90 yrs old of an enrolled individual with keloidal scarring (i.e. the proband).
-subjects must speak English and/or Spanish.
-subjects must be able to provide written informed consent. Written informed consent will be obtained from a parent or guardian of a participant younger than 18 years of age.
-subjects with a current diagnosis or past medical history of cancer are eligible for enrollment in this study