Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus
Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL). A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus.
This study will compare the impact of including exenatide once weekly in addition to usual
care vs. usual care without exenatide on major cardiovascular outcomes as measured by the
primary composite endpoint of cardiovascular-related death, nonfatal myocardial infarction
(MI), or nonfatal stroke.
- Patient has type 2 diabetes mellitus
- Patient has an HbA1c of ≥ 6.5 % and ≤ 10.0% and is currently using one of the
following treatment regimens: A) Treatment with 0-3 oral antihyperglycemic agents B)
Insulin therapy, either alone or in combination with up to two oral agents
- Female patients must not be breast feeding and agree to use an effective method of
contraception or must not otherwise be at risk of becoming pregnant.
- Patient has a diagnosis of type 1 diabetes mellitus, or a history of ketoacidosis.
- Patient has ever been treated with an approved or investigational GLP-1 receptor
- Patient is enrolled in another experimental protocol which involves the use of an
investigational drug or device, or an intervention that would interfere with the
conduct of the trial.
- Patient has a planned or anticipated revascularization procedure.
- Pregnancy or planned pregnancy during the trial period.
- Patient has end-stage renal disease or an estimated glomerular filtration rate (eGFR)
of <30 mL/min/1.73m2.
- Patient has a history of gastroparesis or pancreatitis.
- Personal or family history of medullary thyroid cancer or MEN2 (Multiple
EndocrineNeoplasia Type 2) or calcitonin level of >40 ng/L at baseline.