Dopamine Response to Ultraviolet Light in Frequent and Infrequent Tanners

Study ID
STU 112011-012

Cancer Related

Healthy Volunteers

Study Sites

Julianne Price

Principal Investigator
Bryon Adinoff


The overall goal of this study is to determine if uVR induces striatal dopaminergic efflux and if basal D2/D3 receptors and uVR-induced dopamine efflux is altered in compulsive tanners. Two groups will be tested: a group of frequent, compulsive salon bed tanners and a group of age-, sex-, and skin-phototype matched infrequent tanners. Subjects will be studied under two conditions on two separate days: (1) tanning under a commercially available tanning canopy ([Quote]active uVR[Quote]), and (2) lying under the same canopy with a uVR-filter in place ([Quote]sham uVR[Quote]). The filter allows the visible spectrum of light and heat to come through but blocks uVa and uVB light. Basal D2/D3 receptors and uVR-induced dopamine efflux will be assessed by using 123i-iBZM binding potential (BP) and Single Photon emission Computerized Tomography (SPeCT).

Participant Eligibility

Compulsive Tanners:

* Age: 18-45 years old. As tanning frequency dramatically decreases in subjects over 40 years old (5, 6, 27) and limit variability, only subjects 18-45 y/o will be included. Men and women will be studied.

* Subjects with Fitzpatrick skin type II-V will be included regardless of ethnicity or race (see Section III.B.1). Tanning for skin type I (pale white) is not recommended due to likelihood of burning. Tanning in skin type VI (dark brown or black skin) is unusual due to ineffectiveness. Inclusion of skin type II-V is expected to include more than 90% of tanners (6, 27).

* Subjects report tanning at least two times weekly over the previous year. (The typical tanning interval for frequent tanners is 2-3 times weekly.) At least 50% of the tanning episodes will be in an indoor tanning bed. (Many compulsive tanners tan outside during the summer months).
Infrequent Tanners:
Infrequent tanners will be included as a comparison group. Familiarity with the salon tanning experience, without the compulsive use, offers a more appropriate comparison group than a tanning-naive group. This is similar to studying occasional drinkers or gamblers as comparison groups for alcohol-dependent subjects (30, 31) or pathological gamblers (32), respectively, to assess reward and craving mechanisms.
Inclusion Criteria:

* Similar age, gender, and race/ethnic criteria as for Compulsive Tanners. Infrequent tanners will be recruited to match age, gender, and skin phototype distributions with Compulsive Tanners.

* Reports at least ten lifetime episodes of use of a tanning bed. This will assure familiarity with tanning bed environment.