Neurophysiological Studies in Schizophrenia and Psychiatric Disorders

Study ID
STU 112010-097

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

Contact
Debra Bushong
214-648-4653
debra.bushong@utsouthwestern.edu

Principal Investigator
Carol Tamminga

Summary

Neurophysiological Studies in Schizophrenia and Psychiatric Disorders
This project includes three arms: the core project, matching the NIMH Grant; the secondary project and the pilot project.
The core project is a part of a multi-center study examining the relationships among neurophysiological and cognitive markers of risk and determining how they cluster in families with schizophrenia and other psychotic disorders. We will recruit 200 case probands with a diagnosis of schizophrenia, and other psychotic disorders, including schizoaffective disorder and bipolar I disorder and all available and eligible full siblings, biological parents and children within the age of 15 to 70 (n ~ 340). We propose to recruit 100 age, race, and socioeconomic (county) matched control probands. Total number of subjects is planned as 830 and allows for 30% attrition (640 + 30%). We will collect blood samples from all subjects for DNA analysis and white blood cell immortalization for genetic linkage tests. This information will be integrated with information from neurophysiological and cognitive studies to better categorize psychosis phenotypes. The neurophysiological tests to be performed will be: eye tracking studies, which have been noted to be abnormal in 60% of schizophrenics, prepulse inhibition of the startle response and P50 Sensory gating, which are also abnormal in approximately 30% of schizophrenics. Cognition will also be tested in all subjects to assess whether patients with psychosis and their unaffected family members have similar deficits. This information will be assimilated to give a clearer genotypic and phenotypic classification of schizophrenia and other psychotic disorders.
In the secondary project, we are planning to collect a small sample (~100 subjects), including probands, first degree relatives and normal controls for a secondary analysis, exploring neurophysiological and neurocognitive endophenotypes (e.g., different aspects of eye tracking, PPI, P50, neuroimaging with MRI etc.) and genetic associations.
In the pilot study we have collected 259 subjects to demonstrate the physiability of the Dallas site and reliability of the collected data. These preliminary data are pilot and will be analyzed separately.
The total goal of recruitment is 830 subjects for the core project, matching the NIMH grant; 259 subjects that have been collected in the preliminary study 100 additional subjects for the secondary analysis, which brings the total number to 1189.

Participant Eligibility

CRITERIA FOR INCLUSION OF SUBJECTS:

* Inclusion Criteria for Affected Volunteers:

* DSM-IV diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder.

* Must be judged clinically stable by study investigators.

* Males and females.

* Ages 15- 70 years old.

* All races and ethnicities.

* Voluntary and competent to sign an informed consent.



* Inclusion Criteria for Family Member of Affected Volunteers:

* Must be judged clinically stable by study investigators.

* Males and females.

* Ages 15- 70 years old.

* All races and ethnicities.

* Voluntary and competent to sign an informed consent



* Inclusion Criteria for Normal Volunteers:

* No psychiatric illness in immediate family or self.

* Males and females.

* Ages 15- 70 years old.

* All races and ethnicities.