Protocol For A Research Database For Hematopoietic Stem Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

Study ID
NMDP IRB-1999-0021

Cancer Related
Yes

Healthy Volunteers
No

Study Sites

  • Children’s Medical Center (Dallas, Plano, Southlake)

Contact
Gevel Jackson
214-456-7194
gevel.jackson@childrens.com

Principal Investigator
Victor Aquino

Official Title

Protocol For A Research Database For Hematopoietic Stem Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

Brief Overview


The primary purpose of the Research Database is to have a comprehensive source of
observational data that can be used to study HSC transplantation.

A secondary purpose of the Research Database is to have a comprehensive source of data to
study marrow toxic injuries.

Objectives:

To learn more about what makes stem cell transplants work well, such as determining the
following:

- how well recipients recover from their transplant

- how recovery after a transplant can be improved

- how access to transplant for different groups of patients can be improved

- how well donors recover from the collection procedures

Participant Eligibility


Eligibility to Participate in the Research Database

Recipient Eligibility Criteria:

- Any recipient of an unrelated or related donor or autologous HSC transplant in a
CIBMTR center is eligible to participate in the Research Database. This includes
adults with and without decision making capacity, and children.

Individual with Marrow Toxic Injury Eligibility Criteria:

- Any individual who is treated for a marrow toxic injury at a center participating in
the NMDP's Radiation Injury Transplant Network (RITN) is eligible to participate in
the Research Database. This includes adults with and without decision making
capacity, and children. Eligible individuals may have received supportive care only,
growth factor support, HSC transplant or other appropriate medical treatment for
marrow toxic injury. Treatments applied are at the discretion of the care facility,
and are not determined by the NMDP or CIBMTR.

Unrelated Donor Eligibility Criteria:

- All donors registered on the NMDP Registry who have been requested to donate a
product for a recipient are eligible to participate in the Research Database.

- All maternal cord blood donors are enrolled in the NMDP Cord Blood Bank
Investigational New Drug (IND) protocol, and sign an informed consent document
specific to that protocol. Data collected as part of the Cord Blood Bank protocol are
included in the Research Database.