The Gut Microbiome in Psychiatric Illness
We will recruit participants through our established pipelines at the MDRPC. as part of the screening assessments, psychiatric ratings scales will be used to measure the severity of the participants' depression and anxiety, including questions regarding sleep difficulties, gain or loss in appetite, and problems with concentration. once deemed eligible for our study, these participants will have a blood draw, will provide additional information regarding their psychiatric and medical history, and will be instructed to collect a stool sample for analysis of their gut microbiome and repeated collection of saliva for cortisol measurements. Participants will be provided with collection materials so they can collect the specimens in the privacy of their own home and instructed on how to safely transport these specimens to the study coordinators. Correlation of psychiatric assessments and health data with phylogenetic analysis of the gut microbiome adds an additional component of personalization to best direct treatment and improve our understanding of how individual physiology may contribute to disease state.
* Adults, age 18-64
* Written informed consent obtained
* Outpatients with a current primary diagnosis of nonpsychotic chronic or recurrent MDD,GAD or Anxiety NOS per the SCID-I OR has a family member with the same diagnosis but does not themselves meet criteria OR is a mentally healthy person with no diagnosed psychiatric disorder of any kind, nor any family history of a psychiatric disorder.
* For the patients, having a QIDS-SR score of >=9 or GAD-7 of > 8
* Agrees to all biological collection procedures (stool sample, repeated saliva collection, and blood draw)