UT Neuropsychiatry Research Program: (DBC)

Study ID
STU 102010-053

Cancer Related
No

Healthy Volunteers
No

Study Sites

Contact
Kelly Gleason
214-645-2527
kelly.gleason@utsouthwestern.edu

Principal Investigator
Carol Tamminga

Summary

The uT neuropsychiatry Research Program, formally known as the Dallas Brain Collection, (DBC) is designed to collect, characterize, diagnose, store, and dispense human brain tissue from psychiatric cases and their controls. The purpose of this research is to study the biological foundations of psychiatric diseases. The tissue will be used at uT Southwestern Medical Center and at collaborating laboratories. The research study puts a priority on collecting tissue from people with schizophrenia and the afffective disorders. These are complex diseases of largely unknown origin and the poor prognosis in patients, presents a substantial medical need for this type of research.

Brain tissue will be collected from recently deceased persons who are brought to the Dallas County Medical examiner's office (DCMe), uTSW Transplant Service Center (TSC), the uTSW Willed Body Program (WPB) and Collin County Medical examiner's office (CCMe). The uTSW Transplant Service Center assists in obtaining consents from DCMe cases, non-DCMe cases and CCMe cases. after obtaining permission to use the tissue for research from the next of kin (noK), the tissue is quickly transported to the DBC lab where it will be prepared and stored for research use. We also collect the deceased's medical records and conduct an interview with a family member. after this information is gathered, experienced psychiatrists will prepare a post-mortem diagnosis from all sources of information. Tissues will be assigned case numbers to protect patient identity and ensure double blind studies.

The ideal rate of acquisition is estimated to be 50 donors per year including cases of schizophrenia, unipolar depression, bipolar disorder and a history of substance abuse. normal cases will be collected to be used as controls to the psychiatric cases.

obtaining Tissue. The DBC began collecting on october 1, 2003. either the DBC or its tissue procuring collaborators obtains next-of-kin (noK) permission to collect brain tissue for research. any non-DCMe case where consent is obtained, the uTSW WBP sends a technician to the site to remove and transport the brain to uT Southwestern for dissection. For all cases obtained, the DBC gathers medical records and conducts an interview with a family member or primary care person who was close with the donor. The DBC will often collect prospectively for specific studies, allowing the target tissues to be dissected from the fresh brain and then fixed, frozen or otherwise processed. an emphasis will be put on collecting high quality tissue for subsequent study. each psychiatric case will be matched to a normal control case with similar PMi, age, sex, and Rin. For normal cases, clinical information will be sought to rule out any medical conditions, or psychiatric diagnoses, and specify medication and any drug use histories

Participant Eligibility

Inclusion Criteria for Enrollment: all deceased persons
1. Deceased persons who characteristically have a PMI(Post Mortem Index) of around 24 hours or less
2. Informed consent of Next of Kin (NOK) for donation
3. All ages under 75
4. Male/Female
5. All race/ethnicities
6. Deceased persons with psychiatric illness or other brain disease/ brain region dysfunction
7. Deceased persons with no psychiatric illness or other brain disease/ brain region dysfunction
8. We DO accept IV drug abusers, male homosexuals, and prostitutes
9. We DO accept donors who have received non professional tattoos, body piercings, or acupuncture in the last 12 months