Standardizing creatinine clearance estimation for the Calvert formula to improve the safety and efficacy of carboplatin
The investigators will attempt to determine the most accurate method of estimating creatinine clearance for the Calvert formula by determining actual carboplatin serum concentrations and calculating the resultant AUC. The calculated AUC based on serum concentrations will then be compared to the target AUC noted when calculating each patient and #146;s carboplatin dose. The dosing weight, ideal body weight and actual body as well as serum creatinine will be recorded for each patient. Through statistical manipulation of the weights and adjusted serum creatinines, the creatinine clearance of each patient will then be estimated using the various formulas for estimating creatinine clearance. Each different estimated creatinine clearance will then be inputted into the Calvert formula using the actual measured AUC to calculate a theoretical dose for each patient. Lastly, each theoretical dose will be used to calculate a target AUC. The dose that calculates a target AUC closest to the actual calculated AUC will show the most accurate method of estimating creatinine clearance. The study will cover the span of approximately one year. This study will not affect the pre-determined treatment dose or standard of care for enrolled patients. Patient will continue to be treated according to the standard of care that has previously been established.
1. Male and female subjects that are 18 years of age or older
2. Currently receiving carboplatin or initiating carboplatin utilizing the Calvert formula to achieve a target AUC
3. Non-English speaking Hispanic patients will be included in the study and will have the consent form translated for them.