Lenticulostriate Vasculopathy in Preterm Infants: Characteristics, Associated Conditions, Inter-rater Reliability of Cranial Ultrasound Readings and Long-term follow-up
This is a prospective, case-control study that will be conducted in the neonatal intensive Care unit at Parkland Memorial Hospital (PMH). We will systematically review all of the cranial ultrasound scans routinely obtained at 1, 2 and 4 weeks postnatal and at discharge for VLBW neonates or gestational age [LessThanorequalTo]32 weeks gestation. This will allow us to determine the incidence and persistent of LSV and its association with fetal and neonatal variables, e.g., fetal growth restriction and congenital infections.
LSV will be defined as bright hyperechogenic lesions in the thalamus and/or basal ganglia in a linear or punctate pattern. each neonate with a diagnosis of LSV will be matched with two subsequent preterm neonates born at the same gestational age but without evidence of LSV on routine cranial ultrasound. Fetal and neonatal variables that might be associated with the development of LSV will be collected. Since there continues to be void in our knowledge of the long-term consequences of neonatal LSV, these infants will be followed in the Low Birth Weight Clinic at Children's Medical Center of Dallas, where they routinely receive their medical care through age 3 yrs. The endpoint of the study will be at 36 months, at which time they will be evaluated for neurodevelopmental outcome using Bayley Scales of infant Development by developmental specialist unaware of the group assignment.
Preterm infants gestational age <=32 weeks or birth weigh <=1500 gm and diagnosed with LSV on cranial ultrasound scan will be eligible for entering the study.