Non-invasive Visualization by Diagnostic Ultrasonography of the Radial Artery in Vivo of Normal Subjects and Subjects with Chronic Kidney Disease

Study ID
STU 082013-024

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

Contact
Ashlei Johnson-Wilder
214-648-0394
ashlei.johnson@utsouthwestern.edu

Principal Investigator
Orhan Oz

Summary

To pursue this objective, we intend to conduct a pilot study with diagnostic ultrasonography to help determine whether uCR might yield vascular elasticity, and if so, how to apply it. in healthy human subjects and patients with chronic kidney disease (Stage iii-V), CKD with transplant or eSRD, we will examine their arteries using conventional diagnostic ultrasonography to explore the following questions: are there substantial differences in its location, tortuosity and dimensions (diameter and wall thickness) between normal subjects and subjects with CKD/CKD with transplant/eSRD? Can we document the appearance of calcification or atheromata in the artery? Do normal radial, popliteal, and/or carotid arteries have sufficient ultrasound signature (distinct from surrounding soft tissues) to be amenable for examination by uCR? is the ultrasound signature of calcified or atheromatous artery sufficiently different from that of healthy artery or surrounding tissue that we expect unique uCR features?

10 healthy adult subjects and 18 adult patients with Stages iii-V CKD or end Stage Renal Disease (eSRD) of either gender will be recruited. The subjects will be recruited from an on-going study being conducted by Dr. Miguel Vazquez, a Co-investigator on this study. about one half of the patients are expected to have varying degrees of vascular calcification. all subjects will undergo diagnostic ultrasonography for the visualization of these arteries.

We have initially explored the possibility of obtaining feasibility data by visiting one of the established ultrasound sonography facilities on the uTSW campus. This option was excluded, because of severe constraints of clinical facilities for research pursuits.
We have therefore decided to rent a device (SonoSite S-nerve with the HFL38x transducer, 13-6MHz, 6 cm depth), to be stored and utilized in the Mineral Metabolism Clinic at uTSW's aston Center. Basic operating instructions will be given by manufacturer's representative to our investigators (Swaringen and Poindexter) who are expected to make actual measurements in recruited subjects. Dr. oz will provide overall supervision, and recruit experienced ultrasonographer when necessary for additional instruction or guidance.

Participant Eligibility

Healthy subjects and patients with Stage III-V chronic kidney disease, CKD with transplant and/or ESRD over the age of 18 who are capable and willing to give informed consent.