Procurement of Patient Tissue Samples to Facilitate the Study of Disorders of Mineral Metabolism

Study ID
STU 082010-150

Cancer Related
Yes

Healthy Volunteers
No

Study Sites

  • UT Southwestern Ambulatory Services
  • UT Southwestern University Hospital—St. Paul
  • UT Southwestern University Hospital– Zale Lipshy
  • Parkland Health & Hospital System

Contact
Ashlei Johnson-Wilder
214-648-0394
ashlei.johnson@utsouthwestern.edu

Principal Investigator
Khashayar Sakhaee

Summary

Specimens stored in the repository will be utilized for several ongoing and planned research projects within the Center for Mineral Metabolism. This repository will allow researchers to have access to tissues for a variety of research protocols and activities related to mineral metabolism. The proposed project will help integrate basic and clinical research and will enhance the overall research efforts on campus.

Participant Eligibility

De-identified specimens will come from patients at any of the participating institutions (Zale-Lipshy, Parkland, St. Paul or Aston Ambulatory Care Center) and may also be obtained from a variety of collaborating Institutions in the U.S. The majority of the patients will be undergoing surgery for a specific diagnosis. The tissue utilized in the protocol will be 1) excess tissue that would otherwise be discarded after surgery in adults or minors or 2) non-standard of care kidney specimens obtained from adult patients at the time of elective kidney stone surgery. Patients of all ethnic backgrounds will be included and it is anticipated that some patients will be in poor general health status due to the nature of their diseases (for example, advanced cancer). In those requiring standard of care procedures, no patient will undergo tissue removal for the sole purposes of retrieving tissue for the repository, but rather if surgical or medical indicators require the removal of tissue specimens for therapeutic or diagnostic purposes, efforts will be made to include portions not needed for routine care in the tissue repository. Therefore, these patients will not suffer harm or addition surgical intervention beyond the risk inherent in the medically indicated therapeutic or diagnostic procedures. In patients in whom urological surgery for kidney stone disease is medically indicated, a small specimen of kidney tissue will be obtained during this procedure.