The Effects of Ankle Foot Orthoses (AFOs) on Mobility in Persons with Multiple Sclerosis

Study ID
STU 072013-076

Cancer Related
No

Healthy Volunteers
No

Study Sites

Contact
Staci Shearin
214-648-1551
staci.macklin@utsouthwestern.edu

Principal Investigator
Karen McCain

Summary

This is a non-randomized, single group (n[?]15), repeated measures study. The study will take place at the David M. Crowley Research and Rehabilitation Lab in the School of Health Professions at university of Texas Southwestern Medical Center. The outcome measure for the study include: 1. GaiTRite System for temporal and spatial gait parameters, 2. eMG of the anterior tibialis, gastrocnemius, soleus, and vastus lateralis muscles, 3. 6 Minute Walk Test (gait endurance) 4. Lower extremity strength (dynamometry and single leg heel raise), 5. 12-item MS Walking Scale, 6. Video tape of overground gait analysis, 7. Rate of Perceived exertion (RPe), 8 Quality of life measure. This study will be 24 weeks long. over the 24-week period, the subject will participate in 14 gait training sessions which will be at weeks 1, 2, 3, 4, 5, 6, 8, 10, 12, 14, 17, 20 and 23. The treatments will be 45-60 minutes in duration. outcome measures (all or part) will be assessed at the following times: initial (T1), week 5 (T2), week 13 (T3), and week 24 (T4). Subjects will be closely monitored throughout the 24 week study and will be un-enrolled by self-request or the following medical reasons: 1. acute exacerbation of MS symptoms, 2. new diagnosis with direct consequences affecting gait training, 3. inability to tolerate the aFo.

Participant Eligibility

1. Individuals with a primary diagnosis of multiple sclerosis
2. Individuals >18 and <60 years old
3. Individuals who are able to maintain a walking velocity of 30 cm/sec for at least 2 minutes independently or with the use of a single tip assistive device.
4. Could have current or past history of single or bilateral AFO use, including neuroprostheses
5. Evidence of weakness in plantarflexors