Low-dose UVA1 Radiation in Cutaneous Lupus Patients

Study ID
072012-024

Cancer Related
No

Healthy Volunteers
No

Study Sites

  • UT Southwestern-Clinical Translational Research Center (CTRC)
  • UT Southwestern Ambulatory Services
  • Parkland Health & Hospital System

Contact
Noelle Teske
801/556-6604
noelle.teske@utsouthwestern.edu

Principal Investigator
Benjamin Chong

Official Title

Low-dose UVA1 Radiation in Cutaneous Lupus Patients

Brief Overview


The investigators are conducting an open-label clinical trial determining the effects of
UVA1 phototherapy on cutaneous lupus (CLE) patients. Past research on systemic lupus (SLE)
subjects indicates that this treatment is likely to be effective in treating cutaneous lupus
with few side effects. The fact that most CLE patients are seen at dermatology clinics also
increases the usefulness of this study because there is a large probability that
phototherapy treatment will be accessible for many of the patients that stand to benefit
from it.

Summary


Study subjects will receive low dose (20 J/cm2) UVA1 phototherapy treatment three times per
week for 10 weeks. Each treatment will take less than 30 minutes. This period will be
followed by an eight-week observation phase to assess longer term effects of the treatment.
Patients will be assessed for disease activity, and blood studies and photos will be
completed prior to, during, and after phototherapy treatment. Optional skin biopsies of
affected and unaffected skin will be performed at the beginning and end of the active
treatment phase.

Participant Eligibility


Inclusion Criteria:

- You must be 18 years or older with a diagnosis of cutaneous lupus.

- You must have at least two active areas of cutaneous lupus.

- You will need to come in three days a week for a 10-week period.

- You will need to participate in four physician visits and blood draws.

Exclusion Criteria:

- You do not have a diagnosis of cutaneous lupus.

- You have less than two active areas of cutaneous lupus.

- You are unable to come in three days a week for treatment for a 10-week period.