Banking of Tissue and Establishing Continuous Cell Lines and Xenografts From Neoplasia (South Plains Oncology Consortium Bank [SPOC])

Summary

This protocol will bank tissue from patients with cancer or patients suspected of having cancer to enable future biological and preclinical diagnostic or preclinical therapeutic research. When allowed by the patient, normal blood samples (plasma for proteomic studies and cells for DNA) will be banked to enable future genomic comparisons between cancer and normals cells. For selected types of cancers, the protocol will also seek to initiate continuously growing cell lines and/or xenografts in immunocompromised mice. Cell lines or xenografts will be banked in the form of multiple reference vials containing cryopreserved cells with rigorous quality controls. It is anticipated that the tumor bank and cell line repository that will be created by this protocol will provide a unique and highly useful, renewable resource of biological specimens for cancer research. Because cell lines and xenografts are a renewable resource, after proper characterization they can be widely distributed throughout the cancer research community.

Participant Eligibility

Patients of any age that have provided informed consent, or when applicable, assent.
Patients must be diagnosed with a malignancy. Submission of tissue, bodily fluids, and/or blood with a presumed malignant diagnosis is acceptable, but may or may not be retained in the bank when final histopathology becomes available.
Pathology reports must be available.