Database Registry for Psychotic Disorders (DRPD)

Study ID
STU 072010-201

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

Contact
Debra Bushong
214-648-4653
debra.bushong@utsouthwestern.edu

Principal Investigator
Carol Tamminga

Summary

a database registry will be created for normal controls and patients with psychiatric disorders, such as schizophrenia and schizoaffective disorder. This registry will be used to screen the patients and controls who may qualify for an ongoing or future research study on psychotic disorders. The following demographic and clinical information will be collected for this registry:
name, date of birth and age, race and ethnicity, gender, home address, phone number(s), availability of immediate family members in the Dallas area, education, social security number, marital status, and an emergency contact.
Clinical information: psychiatric history and diagnosis, any known drug allergies, the treating psychiatrist and clinic or facility, weight, height, whether the participant is interested in inpatient studies (subject volunteers only) and/or can be in studies that involve brain imaging, medical history, current medications (including over the counter and herbal products), and criminal history (subject volunteers only--not control volunteers). a Structured Clinical interview Diagnosis (SCiD) will be completed on the volunteers' initial visit. The Wide Range achievement Test 4 (WRaT4) may also be completed by the volunteer. This tests looks at academic achievement. it tests sentence comprehension, word reading, spelling and math computation. Completion of this interview will help place the volunteers in the appropriate study.
all volunteers will be compensated $15 for participating in the DRPD. The SCiD can take two to three hours to complete.
Subject volunteers and control volunteers may be asked to also participate in a Dna Database Registry for future studies. The blood draw portion of the database registry is completely optional and not required to be in the database registry or in other studies. The volunteer will meet with a doctor, nurse, or study coordinator who will draw 4-5 tablespoons of blood. once the blood draw is complete the volunteers will receive an additional compensation for this participation. Volunteers will be paid $15 to participate in the Dna Database.
after volunteering for the Dna Database, the subject volunteers and control volunteers may be asked to also participate in an fibroblast cell database for future studies. The dermal biopsies will be used to develop fibroblast cell cultures; then these fibroblast cultures will be transformed into induced pluripotent stem cells (iPS); the stem cells can be used to culture neurons which will provide neuronal and synaptic characteristics of the individual and might model cell systems in that individual's own brain. each of the fibroblast cultures that are develop will be associated with a known human volunteer who is already clinically characterized and diagnosed, with banked Dna. Characteristics of the cell cultures will be used as cellular intermediate phenotypes. Volunteers will be paid $45 donating a dermal biopsy sample.
There is an optional sub-study that will be offered to some participants who are diagnosed with a primary affective disorder, such as Bipolar disorder. These individuals will be asked to wear an actigraph monitoring watch for 2 weeks. They will be given assessments at the beginning and end of their participation regarding symptoms of their illness, such as mood. additionally, they will maintain a diary of sleep habits and mood over the duration of the time that they are wearing the actigraph watch. upon the completion of the 2 week period and all assessments, participants will be paid $100.

Participant Eligibility

All subjects with a diagnosis of a psychotic disorder, such as schizophrenia or schizoaffective disorder will be eligible for this registry regardless of age, gender, race, or ethnicity. Healthy subjects will also be recruited for this registry as normal controls. All volunteers will be between the ages of 15 to 70.