Collecting Tissue Samples From Patients With Cancer Undergoing Radiation Therapy

Study ID
CDR0000653406

Cancer Related
Yes

Healthy Volunteers
No

Study Sites

  • UT Southwestern-Other
  • Clements University Hospital
  • Richardson Regional Cancer Center
  • Zale Lipshy University Hospital
  • UT Southwestern Moncrieff Cancer Center
  • Parkland Health & Hospital System

Contact
Suprabha Pulipparacharuvil
214/645-7219
suprabha.pulipparacharuvil@utsouthwestern.edu

Principal Investigator
Hak Choy, M.D.

Official Title

Tissue Procurement and Outcome Collection for Radiotherapy Treated Patients

Brief Overview


RATIONALE: Collecting and storing samples of tissue from patients with cancer to test in the
laboratory may help the study of cancer in the future.

PURPOSE: This research study is collecting tissue samples from patients with cancer
undergoing radiation therapy.

Summary


OBJECTIVES:

Primary

- To maintain and create a University of Texas Southwestern Medical Center (UTSW)
Radiation Oncology Tissue Resource and Registry/Database that will be used to explore
genetic variations contributing to clinical outcomes through tissue analysis and
outcome correlation. Tissue will be stored by the UTSTR and the database managed by
Radiation Oncology.

Secondary

- To document disease outcome (local recurrence, distant metastasis, overall survival) by
treatment regimen and disease site.

- To document toxicity by treatment regimen and disease site.

- To establish a prospective registry/database consisting of patient demographics and
outcomes to be used for future research.

OUTLINE: Tissue, including surgical waste, venous blood/serum, urine, bone marrow, and other
body fluids, may be collected (at planned surgery and routine medical visits) and preserved
for future research. Demographic and disease and treatment information is obtained from
patients (by interview or questionnaire), from medical records, and from national datasets.
Patients may also be asked to provide additional blood samples and/or a small skin-punch
biopsy sample.

Patients are followed up every 6 months for the first two years following treatment and then
yearly thereafter.

Participant Eligibility


DISEASE CHARACTERISTICS:

- Pathologically-proven diagnosis of malignancy

- Planning treatment with radiation therapy

PATIENT CHARACTERISTICS:

- Able to perform follow-up visits

- Is a patient of the University of Texas Southwestern Medical Center physicians

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- Participation in other clinical trials is allowed

- Other prior or concurrent therapy for cancer, such as surgery and/or chemotherapy, is
allowed