High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors

Study ID
STU 062010-160

Cancer Related

Healthy Volunteers

Study Sites

  • Clements University Hospital
  • UT Southwestern Ambulatory Services
  • Zale Lipshy University Hospital
  • Parkland Health & Hospital System

Sarah McNeil

Principal Investigator
Elizabeth Maher, M.D., Ph.D.

Official Title

High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors

Brief Overview

The study will compare two different size MRI's of a brain tumor.


The study is designed to directly compare the MR images of a brain tumor obtained on the 3T
and then 7T MRI in approximately 150 patients followed serially with MR imaging to evaluate
for tumor progression.

Participant Eligibility

Inclusion Criteria:

- Male or female, age 18 years or older

- Patient must meet at least one of the four following criteria regarding brain tumor

- Histological diagnosis of a brain tumor

- Histological diagnosis of systemic cancer and brain MR imaging suggestive of
metastatic disease to the brain

- Pre-operative brain MR imaging suggestive of a brain tumor

- Radiographic diagnosis of brain tumor in an inoperable location (e.g., brainstem)

- Patient able and willing to provide informed consent

- Karnofsky Performance status > 70%

- Life expectancy greater than 3 months

- Negative serum or urine pregnancy test or child bearing potential terminated by
surgery, radiation, menopause or current use of two approved methods of birth control

- Patients who are excluded from 7T MR imaging because of titanium implants that are
not yet established to be safe at 7T remain eligible for the imaging at 3T * Spanish
speaking participants will be enrolled for this study

Exclusion Criteria:

- Body weight >137 Kg (300 lbs)

- Patient unable to provide informed consent

- Karnofsky Performance status < 70%

- Patients who are claustrophobic or have other contraindications to MRI, such as
implanted pacemaker device vascular clips, surgical clips, prosthetic valves,
pacemakers, otologic implants

- NYHA class III and IV congestive heart failure

- Psychiatric or addictive disorders that preclude obtaining informed consent

- Unstable angina

- Sexually active patients of childbearing potential not using a reliable contraceptive

- Pregnant or lactating women

- Women of childbearing potential who refuse a pregnancy test (performed during