Occult Gastrointestinal Bleeding caused by Portal Hypertensive Gastropathy in patients with Chronic Liver Disease

Study ID
STU 062010-109

Cancer Related
No

Healthy Volunteers
No

Study Sites

Contact
Rebecca Chason
214-590-6607
rebecca.chason@utsouthwestern.edu

Principal Investigator
Amit Singal

Summary

This study is an observational cross-sectional study. Patients with chronic liver disease who meet inclusion criteria (see below) will be asked to participate in the study. once subjects agree , proper written informed consent and HiPPa forms will be signed. Patients will undergo the following procedures:
- Blood drawn for hemoglobin and serum ferritin. Blood drawn can be done at the moment of evaluation in Gastrointestinal laboratory (Gi lab), liver clinic or CoPC clinic.
- Previously scheduled upper endoscopy and/or colonoscopy as part of their standard medical care.
- Formal stool testing using hemoccult and hemoquant will be performed. Patients will be asked to collect stool samples and to bring it back to the investigator.
These procedures will be performed only one time. no follow up will be needed as part of this study. Follow up will be done as part of the standard of medical care.
after all procedures, we will separate patients into 4 different groups for further statistical analysis:
-Group 1: patients with oGiB and PHG
-Group 2: patients with oGiB without PHG
-Group 3: patients without oGiB and with PHG
-Group 4: patients without oGiB and without PHG
We anticipate that the identification of these groups of participants will be beneficial for future studies.

Participant Eligibility

Patients between ages 18 and 65 years old with clinical-pathological evidence of chronic liver disease (i.e. based on liver biopsy, laboratory features or computer tomography or ultrasound features).