The Effect of Heat Intolerance on Exercise and Physical Function

Study ID
STU 052013-015

Cancer Related
No

Healthy Volunteers
No

Study Sites

Contact
Cynthia Dolezal
214-648-2735
cindy.dolezal@utsouthwestern.edu

Principal Investigator
Karen Kowalske

Summary

This is a prospective, randomized single center study on the efficacy of an exercise intervention program and outcomes relating to heat intolerance among survivors of a burn injury.

There are two treatment groups, experimental and control. Randomization will occur after the subject consents. a series of questionnaires will be completed by both groups at the beginning of the study and at 6 months follow-up. Follow-up may occur in person, via a telephone call or by mail. There will be no further intervention with the control group.

The experimental group will receive treatment intervention, 2 sessions of thermal exercise stress testing, either walking or riding a cycle ergometer in hyperthermic environmental conditions (35[Degrees]C and 30% relative humidity) for 60 min per session. Prior to initiating the exercise sessions body weight will be measured and a urine sample will be taken.

The selected relative workload (e.g., 60% of maximal aerobic capacity) will allow an equal challenge to those who are fit and those who are less fit. Heart rate and rhythm, skin and internal temperatures and blood pressure will be measured throughout baseline periods and the exercise protocol via a multi-channel data acquisition system. arterial blood pressure, measured via R-wave triggered sphygmomanometry of the brachial artery will be obtained as needed. Heat perception using a validated scale will be measured every 10 minutes. The subject will be scheduled to return for a second session in which similar measurements as in session 1 will be recorded with no change in protocol.

a critical aspect of the this exercise intervention challenge is the feedback and comfort that the subjects receive from trained nurses and laboratory personnel assuring the subjects that they are safe as they perform the prescribed bout, regardless of their concern or perception of how hot they may feel.

Participant Eligibility


* Total body surface area burn (TBSA) <= 40%

* Age 18 or greater

* At least 3 months post burn

* Less than 5% TBSA open wound