H-29892, Case Ascertainment for Epidemiologic Studies of Childhood Cancers
Texas Children and amp;apos;s Cancer Center houses the Childhood Cancer Epidemiology and Prevention Center (CCEPC), which has developed the infrastructure to obtain questionnaire data from a large number of participants and to collect, process, and store biological samples for large epidemiological studies.
Investigators in the CCEPC are well versed in the conduct of large epidemiological studies of childhood cancer. Therefore, the CCEPC will administer the epidemiological questionnaire for all subjects who are enrolled on this trial. At the time the questionnaire is administered, the subject and amp;apos;s parents will be asked to donate a saliva sample for DNA extraction. We will then mail a saliva collection kit to the parents with instructions for collecting the sample and mailing it back to the CCEPC. Epidemiological characteristics, DNA polymorphisms and levels of plasma proteins that are direct or indirect markers of environmental, dietary and infectious exposures, and encoded by the polymorphic genes in xenobiotic detoxification, DNA repair, apoptosis, inflammation and cell cycle pathways will be compared between pediatric cancer patients and healthy controls or among the families of the cases. A suitable set of population-based controls will be recruited under a separate protocol using either pediatric clinics in the relevant areas of Texas and Oklahoma or the corresponding birth certificate registries. Both sources of controls have their pros and cons; this decision will be made by the study group with input from other epidemiologists with expertise in conducting large population-based casecontrol studies of childhood diseases. The laboratory assays will be guided by a priori hypotheses and by the epidemiological questionnaire. If the questionnaire suggests there is a difference in infection prevalence then we will focus on biological markers related to infections/inflammation (inflammation/cytokine levels, cytokine polymorphism comparisons). If the questionnaire suggests that there is a dietary difference in vitamin (e.g. folic acid) intake, then we would focus on biological markers related to that vitamin (folate serum level, folate polymorphism comparisons).
1. Diagnosis of a childhood cancer
2. Age 18 years or younger at diagnosis
Inclusion Criteria for Control group:
1. Any infant/child/adolescent younger than 18 years of age who is not diagnosed or treated for cancer or any chronic morbid condition as listed in the exclusion criteria defined below.
2. Any ll healthy siblings of children and adolescents diagnosed with cancer under the age of 18 years.