Human Analogs of RAE-1 (Retinoic Acid Early Transcript): Post-Transplant Rejection and Acute Renal Failure

Study ID
STU 042011-140

Cancer Related
No

Healthy Volunteers
No

Study Sites

  • UT Southwestern University Hospital—St. Paul
  • UT Southwestern University Hospital– Zale Lipshy
  • Parkland Health & Hospital System

Contact
Tammy Lightfoot
214-645-8265
tammy.lightfoot@utsouthwestern.edu

Principal Investigator
Christopher Lu

Summary

Group 1: 10 Subjects undergoing native nephrectomies for urologic indications,
Group 2: 10 transplant recipients of living donor kidneys,
Group 3: 10 transplant recipients of deceased donor kidneys, and
Group 4: 10 transplant recipients of decreased donor kidneys over the age of 64, or over the age of 50 plus death from cerebral vascular accident or a serum creatinine greater than 1.5mg/dl

Groups 3 and 4 are defined by the United Network for Organ Sharing (UNOS).

Relationship to proband: N/A

Patients will be routinely followed in the transplant clinic during their standard of care appointments. Transplant recipients will be followed for 5 years. The biopsy sample will be collected during the recipients transplant surgery

Group 5: An outside non-UT Southwestern facility named Southwest Transplant Alliance, Dallas, Texas will provide 20 discard or non-transplanted kidneys from cadavers that have been turned down by transplant center due to poor quality. The cadaver kidneys will be used to test the analytical technology to assure that the procedures are reliable before they are performed on the UT Southwestern acquired kidneys.

Participant Eligibility

Donor Samples From UT Southwestern

Subjects will be 18 years of age or older (adult transplant program), males or females and of any race or ethnic background. Spanish-speaking subjects will be provided with an informed consent and HIPAA Authorization in Spanish and a translator will be available.

Subjects to be enrolled include:

Group 1: 10 Subjects undergoing native nephrectomies for urologic indications,
Group 2: 10 transplant recipients of living donor kidneys,
Group 3: 10 transplant recipients of deceased donor kidneys, and
Group 4: 10 transplant recipients of decreased donor kidneys over the age of 64, or over the age of 50 plus death from cerebral vascular accident or a serum creatinine greater than 1.5mg/dl

Groups 3 and 4 are defined by the United Network for Organ Sharing (UNOS).

Relationship to proband: N/A

Patients will be routinely followed in the transplant clinic.

Donor Sample from Outside Source:

Group 5: An outside non-UT Southwestern facility named Southwest Transplant Alliance, Dallas, Texas will provide 20 discard or non-transplanted kidneys from cadavers that have been turned down by transplant center due to poor quality. The cadaver kidneys will be used to test the analytical technology to assure that the procedures are reliable before they are performed on the UT Southwestern acquired kidneys.