Randomized Trial of the Safety and Effectiveness of 3% vs. 23% Hypertonic Saline for the Treatment of Pediatric Intracranial Hypertension: A Pilot Study
In each arm, intracranial pressure will be measured every 15 minutes for four hours from the end of the hypertonic saline infusion. Primary study endpoint will be the amount of decrease in ICP after HTS administration. Secondary study endpoints will be the number of ICP spikes within 3 hours after HTS administration.
- Children between the ages of 3 months and 18 years of age.
- Diagnosed traumatic brain injury (penetrating or non-penetrating)
- Glasgow Coma Scale score of 8 or less
- Glasgow Motor component less than 6
- Need for osmotic therapy (based on ICP measurement)